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Biomedical subjects

X S Xiao

Publications and source records attributed to X S Xiao.

9 recordsLinked to original sources
PubMed2001

Treatment of malignant digestive tract obstruction by combined intraluminal stent installation and intra-arterial drug infusion.

AIM: To study the palliative treatment of malignant obstruction of digestive tract with placement of intraluminal stent combined with intra-arterial infusion of chemotherapeutic drugs. METHODS: A total of 281 cases of digestive tract malignant obstruction were given per oral (esophagus, stomach, duodenum and jejunum), per anal (colon and rectum) and percutaneous transhepatic (biliary) installation of metallic stent. Among them, 203 cases received drug infusion by cannulation of tumor supplying artery with Seldinger's technique. RESULTS: Altogether 350 stents were installed in 281 cases, obstructive symptoms were relieved or ameliorated after installation. Occurrence of restenotic obstruction was 8-43 weeks among those with intra-arterial drug infusion, which was later than 4-26 weeks in the group with only stent installation. The average survival time of the former group was 43 (3-105) weeks, which was significantly longer than 13 (3-24) weeks of the latter group. CONCLUSION: Intraluminal placement of stent combined with intra-arterial infusion chemotherapy is one of the effective palliative therapies for malignant obstruction of the digestive tract with symptomatic as well as etiological treatment.

Adult↗
PubMed1993

[Effect of DGAVP and Org2766 on intracellular free Ca2+ concentration in dissociated brain cells].

Intracellular free calcium concentration ([Ca2+]i) was measured with Fura-2 in freshly dissociated brain cells isolated from newborn (1-2 day) mouse pups using AR-CM-MIC cation measurement system, and the effects of DGAVP and Org2766 on the changes in [Ca2+]i induced by the protein synthesis inhibitor anisomycin (ANI) were studied. The results indicate that anisomycin caused dose-dependent increases in [Ca2+]i; and DGAVP itself showed no significant effect on [Ca2+]i, but an appropriate dose of DGAVP antagonized the increases induced by the selective dose-range of ANI, suggesting that the antagonism of ANI-induced inhibition of protein synthesis by DGAVP was likely achieved by preventing ANI from increasing [Ca2+]i, but this mechanism did not apply to the other neuropeptide Org2766. Therefore, we suppose that the mechanism of the two neuropeptides are different in terms of their effect on intracellular free calcium concentration.

Adrenocorticotropic Hormone↗
PubMed1992

[Correlation between synaptic protein phosphorylation in hippocampi and shuttle box avoidance behavior].

The present investigation was undertaken to detect whether protein phosphorylation levels of hippocampal synaptosomes in mice trained on shuttle box avoidance task would show some changes. The synaptosomes were prepared at different times after the conclusion of training and labelled with gamma-32P-ATP for in vitro determination. The results are as follows: (1) No significant differences were found in the phosphorylation of synaptosomal proteins in different brain areas in normal mice before training. (2) Immediately after the conclusion of shuttle box avoidance task there appears a correlation between protein phosphorylation levels in hippocampal synaptosomes and the degree of success of training. (3) 24 h after the completion of training the above relationship is more significant, and protein phosphorylation levels of right hippocampus in Good Score Group is markedly higher than that of left one, but in the Inferior Score Group, the left-right difference is reverse. The formation of such asymmetry in protein phosphorylation in hippocampi is unknown. These data indicate that the synaptic protein phosphorylation in hippocampi might be a molecular mechanism of acquisition.

Animals↗
PubMed1984

Neuropeptides related to neurohypophyseal hormones interfere with apomorphine-induced behavioral changes.

The interaction between peptides related to neurohypophyseal hormones and brain dopaminergic systems was studied by investigating in rats the effect of these peptides on behavioral changes induced by graded doses of the specific dopamine agonist apomorphine. Low doses of this drug induce hypoactivity of the animals, while higher doses result in hyperactivity and stereotyped sniffing. Desglycinamide9[Arg8]vasopressin (DG-AVP), prolyl-leucyl-glycinamide (PLG) and oxytocin did not interfere with the behavioral responses induced by the higher doses of apomorphine. Peptide treatment made the rats more sensitive to apomorphine with respect to the drug induced hypoactivity. PLG and especially DG-AVP were more effective than oxytocin. It is concluded that these peptides may have a selective action on distinct dopaminergic receptor systems in the brain, that are presumably located presynaptically in the nucleus accumbens area.

Animals↗