Biomedical subjects

X Tomás

Publications and source records attributed to X Tomás.

6 recordsLinked to original sources

PubMed2000

[Tolerability and safety of levofloxacinin long-term treatment].

Levofloxacin is a useful quinolone for patients infected with osteomyelitis or tuberculosis. There is little information on the tolerance and safety of levofloxacin in long-term treatment. Fifteen patients (10 men and 5 women) with prosthetic joint infection or chronic osteomyelitis were analyzed. The treatment was levofloxacin (500 mg/d) and rifampicin (600 mg/d). Controls were performed monthly during the treatment, and after that every six months. Problems that were likely related to medication were noted by medical interview. Analyses of hepatic and renal function were performed at each visit. The mean age was 64 years. Ten patients had prosthetic joint infection, two chronic osteomyelitis, two osteosynthetic device infection and one silicone graft infection. Staphylococcus aureus was isolated in eight cases, staphylococcus coagulase being negative in five, and the cultures negative in two cases. The mean duration of treatment was 3.6 months (range 2-6 months). No adverse reactions were observed in seven patients (46%). Occasional digestive symptoms were reported in six patients (40%), and two cases (13%) presented light diarrhea. These patients also took antiinflammatory treatment. Sleeplessness was observed in one patient (6%). Tendinitis or alterations in hepatic function were not observed. In no case was the treatment changed due to adverse reactions. It was concluded that levofloxacin is well tolerated and safe and could be an option for infections that require long-term treatment.

Aged↗

PubMed1999

Prediction of wine foaming.

A procedure for estimating the foam properties of sparkling base wines without specifically measuring foam was developed. This method was based on mathematical equations established between the usual parameters of wine quality control (independent variables of the equations) and the wine foam parameters [foamability (HM), Bikerman coefficient (Sigma), and surface tension (ST)] obtained with the specific equipment (dependent variables of the equations). Ninety-six white wines from the Cava region produced at industrial scale were used to establish these equations. Two predictive equations that could be applied to different types of wine from different origins were obtained: one to predict the foamability (HM) and the other to predict the Bikerman coefficient (Sigma). Moreover, the database of foam parameters of the 96 wines allowed a qualitative assessment of wine foaming values.

Food Handling↗

PubMed1995

Is MRI helpful in evaluating the response of cervical cancer to neoadjuvant chemotherapy?

BACKGROUND: To assess the potential role of magnetic resonance imaging (MRI) in evaluating the response of cervical tumor to neoadjuvant chemotherapy. METHODS: We studied 14 patients with locally advanced carcinoma of the cervix. MRI was performed before and after each cycle. All patients underwent laparotomy four weeks after the last cycle. MR images after chemotherapy were compared with surgical-pathologic findings. RESULTS: Related to parametrial state after chemotherapy, surgical examination correlated with MRI in nine patients (nine true negative). In three cases parametrial invasion was over-estimated (three false-positive) and in two it was underestimated, so that tumor resection was not possible once laparotomy was performed (two false-negative). MRI estimation of tumor size was confirmed at pathologic examination in only eight patients, whilst it was over-estimated in the other four ones. CONCLUSIONS: These initial results suggest that MRI could not be as precise for cervix cancer staging and evaluation of response to chemotherapy as has recently been postulated. This is especially important since a false negative result may induce the surgeon to perform laparotomy in error in cases of unresectable tumors.

Adult↗

PubMed1994

Spectrophotometric determination of pharmaceutical dosages by partial least-squares calibration.

Partial least-squares calibration was used for the spectrophotometric determination of the active compound and preservative in a syrup also containing several light absorbing excipients. The calibration matrix was constructed from laboratory-made mixtures of the analytes and excipients and was used to quantify three samples from different batches. The most suitable conditions for quantitation were determined and the results obtained are compared with those provided by HPLC.

Butyrophenones↗

PubMed1993

Injected silicone: radiologic appearance.

The authors describe the radiologic appearance of fluid silicone in the soft tissues of the gluteal area in a transsexual man. Thickening and striation of the soft tissues was observed in the trochanteric area in plain films. Serpiginous hyper-attenuated bands infiltrating the subcutaneous fat were seen with computed tomography. The patient was asymptomatic in the gluteal area.

Adipose Tissue↗

PubMed1991

[The gastrointestinal concealment of illegal drugs].

The clinical, radiological and analytical aspects, and the complications observed in 16 cases of swallowing or insertion into the rectum of illicit drugs ("body-packing") are described. The drugs detected were heroin (6 cases), cocaine (5 cases) and cannabis (5 cases). In 15 cases abdominal plain X-rays were useful in the detection of the drug packages, their position and progression in the gastrointestinal tract and the presence of complications. The most valuable finding for radiologic diagnosis was the presence of a radiolucent halo surrounding the drug packages, or "double condom" sign, which was observed in 13/15 cases (87%). Urine analysis was positive for opiates or metabolites of cocaine in 7/9 cases (78%). One case presented acute heroin intoxication and three subjects gastric or intestinal obstruction requiring surgical treatment. In another case a packet, which had been retained in the stomach for five days, was extracted by upper gastrointestinal endoscopy using a Dormia basket with no complications.

Adult↗