Chromosomal localization, spatio-temporal distribution and polymorphism of the porcine tripartite motif-containing 55 (TRIM55) gene.
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Animals↗
Biomedical subjects
X W Xu
Publications and source records attributed to X W Xu.
Evidence for TeV gamma-ray emission from a region of the galactic plane.
Gamma-ray emission from a narrow band at the galactic equator has previously been detected up to 30 GeV. We report evidence for a TeV gamma-ray signal from a region of the galactic plane by Milagro, a large-field-of-view water Cherenkov detector for extensive air showers. An excess with a significance of 4.5 standard deviations has been observed from the region of galactic longitude l E (40 degrees, 100 degrees) and latitude /b/ < 5 degrees. Under the assumption of a simple power law spectrum, with no cutoff in the EGRET-Milagro energy range, the measured integral flux is phi gamma(>3.5 TeV) = (6.4 +/- 1.4 +/- 2.1) x 10(-11) cm(-2) s(-1) sr(-1). This flux is consistent with an extrapolation of the EGRET spectrum between 1 and 30 GeV in this galactic region.
Journal Article↗
Radiation hybrid mapping of the porcine PPP2CA, PPP2CB, PPP2R1A and PPP2R1B genes.
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Animals↗
Radiation hybrid mapping of porcine CMYA2 and CMYA4.
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Animals↗
Development of an improved CAD scheme for automated detection of lung nodules in digital chest images.
Lung cancer is the leading cause of cancer deaths in men and women in the United States, with a 5-year survival rate of only about 13%. However, this survival rate can be improved to 47% if the disease is diagnosed and treated at an early stage. In this study, we developed an improved computer-aided diagnosis (CAD) scheme for the automated detection of lung nodules in digital chest images to assist radiologists, who could miss up to 30% of the actually positive cases in their daily practice. Two hundred PA chest radiographs, 100 normals and 100 abnormals, were used as the database for our study. The presence of nodules in the 100 abnormal cases was confirmed by two experienced radiologists on the basis of CT scans or radiographic follow-up. In our CAD scheme, nodule candidates were selected initially by multiple gray-level thresholding of the difference image (which corresponds to the subtraction of a signal-enhanced image and a signal-suppressed image) and then classified into six groups. A large number of false positives were eliminated by adaptive rule-based tests and an artificial neural network (ANN). The CAD scheme achieved, on average, a sensitivity of 70% with 1.7 false positives per chest image, a performance which was substantially better as compared with other studies. The CPU time for the processing of one chest image was about 20 seconds on an IBM RISC/6000 Powerstation 590. We believe that the CAD scheme with the current performance is ready for initial clinical evaluation.
Adult↗
Digital chest radiography: effect of temporal subtraction images on detection accuracy.
PURPOSE: To improve early detection of disease in chest radiographs, the authors developed a digital processing technique that geometrically warps and subtracts a previous radiograph from a current radiograph to produce a temporal subtraction image. An observer test was performed to evaluate the effects of the temporal subtraction image technique on detection of interval change. MATERIALS AND METHODS: Fifty pairs of chest radiographs, including a baseline examination and a subsequent radiograph, were selected (25 cases in which potentially important new abnormalities had developed, and 25 in which there was no interval change). The baseline examination was chosen from multiple prior radiographs to minimize initial misregistration. By means of receiver operating characteristic (ROC) analysis, the ability of 11 observers to detect pathologic change when viewing the paired digitized baseline and subsequent radiographs was compared with their ability when viewing the same paired radiographs together with temporal subtraction images. Positive cases demonstrated focal new abnormalities that were greater than 1 cm in diameter. RESULTS: The mean area (Az) under the ROC curves increased from 0.89 without to 0.98 with the temporal subtraction images. When the paired digitized previous and current chest radiographs were viewed in conjunction with the temporal subtraction images, a significant improvement in detection of new abnormalities was achieved (P = .00004), whereas the mean interpretation time was reduced by 19.3% (from 52 to 42 seconds, including the time to record the score and to move to the next case) (P = .0019). CONCLUSION: The temporal subtraction technique can significantly improve sensitivity and specificity for detection of interval change in chest radiographs.
Humans↗
Image feature analysis for computer-aided diagnosis: detection of right and left hemidiaphragm edges and delineation of lung field in chest radiographs.
Diaphragm edges, together with ribcage edges, in chest radiographs provide useful information on the location, shape, and size of the lung fields that are required by computer-aided diagnosis (CAD) schemes for automated detection of various abnormalities. In this continued study, we developed a computerized method for detection of the right and left hemidiaphragm edges. First, the right hemidiaphragm edges in a PA (postero-anterior) chest image were determined by edge gradient analysis. An initial vertical ROI was then placed at the middle of the left hemidiaphragm, based on a "standard rule" for determination of the starting points to search for the left hemidiaphragm edges. Seven categories were used to assess the accuracy of the placement of the initial ROI and the selection of the primary left starting point within the initial ROI. For some categories, it was necessary to select a second left starting point besides the primary one. Therefore, for these categories, two sets of "detected left hemidiaphragm edges" resulted from the two left starting points. Two parameters were used as measures to eliminate the false left hemidiaphragm edges which were due to an incorrect left starting point. Two polynomial functions were applied separately which produced smooth curves for the right and left hemidiaphragm edges. Finally, the delineation of the lung field in a chest image was obtained by connecting the right and left hemidiaphragm edge curves with the corresponding ribcage edge curves. The subjective evaluation results indicated that the accuracy for the determination of the right and left hemidiaphragm edges was approximately 97% and 90%, respectively.
Biophysical Phenomena↗
Effect of a computer-aided diagnosis scheme on radiologists' performance in detection of lung nodules on radiographs.
PURPOSE: To evaluate the effect of a computer-aided diagnosis (CAD) scheme on radiologists' performance in the detection of lung nodules, and to examine a new method of receiver operating characteristic (ROC) analysis. MATERIALS AND METHODS: One hundred twenty radiographs (60 normal and 60 abnormal with lung nodules of varying subtlety) were used. Sixteen radiologists (two thoracic, six general, and eight residents) participated in an observer study in which they read both conventional radiographs and digitized radiographs. The radiologists' performance was evaluated with ROC analysis with two different methods (independent testing and sequential testing) and a continuous rating scale. RESULTS: Az (area under the best fit binormal ROC curve when it is plotted in the unit square) values obtained from ROC analysis with and without CAD output were 0.940 and 0.894, respectively, in the independent test and 0.948 and 0.906, respectively, in the sequential test. Findings with both methods indicated that the CAD scheme statistically significantly improved diagnostic accuracy, particularly for radiologists with less experience (P < .001). Reading time was not increased when CAD was used. CONCLUSION: The CAD scheme can assist radiologists in the detection of lung nodules on chest radiographs.
Adult↗
Image feature analysis for computer-aided diagnosis: accurate determination of ribcage boundary in chest radiographs.
A computerized method for accurate determination of the ribcage boundary in chest images has been developed for use in computer-aided diagnosis (CAD) schemes for automated detection of abnormalities such as the pulmonary lung nodules, pneumothorax, interstitial disease, cardiomegaly, and interval changes in clinical chest images. With our method, the average position of the top of the lung in the chest image is determined first. Top lung edges and ribcage edges are determined within search ROIs, which are selected over top lung cages and ribcages. Three polynomial functions are applied separately to yield smooth curves for top lung edges and right and left ribcage edges. The complete ribcage boundary is then obtained by smoothly connecting three curves. A total of 1000 radiographs were digitized to 1k x 1k matrix size and a 10-bit gray scale with a laser scanner and analyzed by our method. The subjective evaluation indicated that our method produced moderately to highly accurate results in approximately 96% of the 1000 cases examined.
Humans↗
[Uses of angiotensin converting enzyme inhibitor in kidney diseases].
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Angiotensin-Converting Enzyme Inhibitors↗
Development of a digital duplication system for portable chest radiographs.
To provide high-quality duplicate chest images for the intensive care units, we have developed a digital duplication system in which film digitization is performed in conjunction with nonlinear density correction, contrast adjustment, and unsharp mask filtering. This system provides consistent image densities over a wide exposure range and enhancement of structures in the mediastinum and upper abdominal areas, improving visibility of catheters and tubes. The image quality is often superior to that of the original radiograph and is more consistent from day to day. Repeat rates for portable chest radiographs have been reduced by more than a factor of two since implementation of digitization in December 1991, and the number of repeat examinations caused by exposure errors have been substantially reduced.
Computer Systems↗
Clinical experience with an advanced laser digitizer for cost-effective digital radiography.
Film digitization has not been widely pursued in clinical settings mainly because of perceived limitations involving film latitude and image quality. However, a high-quality laser digitizer can be combined with wide-latitude film and specially developed digital processing techniques to achieve image quality comparable or superior to that of storage phosphor computed radiography (SPR) over a wide range of exposure. This film digitization system provides the operational advantages of digital radiography, such as consistent image density, high-quality inexpensive duplicates, and digital storage and retrieval capability. The reliability and monetary costs of the system also compare favorably with those of SPR. In the long term, technologies that employ reusable plates and do not require chemical processing to produce diagnostic images may well replace screen-film systems. Presently, however, film digitization remains a practical and cost-effective approach to digital radiography.
Cost-Benefit Analysis↗
Evaluation of imaging properties of a laser film digitizer.
In this paper we provide a quantitative assessment of the basic imaging properties of a laser film digitizer. The characteristic curve of the digitizer was determined in terms of the relationship between input optical density and output pixel value. Spatial resolution of the laser digitizer was characterized using the presampling modulation transfer function (MTF), which was measured using a curve fitting technique with an angulated slit. For the noise analysis, we compared the Wiener spectra of uniformly exposed film samples before and after digitization. The effects of different sampling distances and scanning directions were investigated. Our results show that the characteristic curve of the laser digitizer was linear. The presampling MTFs of the digitizer were similar at different sampling distances and were substantially greater in the vertical scanning direction than in the horizontal direction. The noise of the digitized film sample was mainly affected by the presampling MTF and structure noise of the digitizer.
Evaluation Studies as Topic↗
Direct comparison of conventional and computed radiography with a dual-image recording technique.
To compare the image quality of computed radiographic (CR) with conventional screen-film images, the authors used a dual-image recording technique. Images were simultaneously acquired with a conventional screen-film combination and a storage-phosphor imaging plate loaded into a single cassette. Wiener spectra and modulation transfer function were compared for both image types. A preliminary observer performance test was conducted with chest images obtained with the dual-image recording technique on portable and fixed equipment. Analysis of physical parameters and observer test results suggests that the conventional screen-film system can provide slightly superior image quality, although the CR system has some advantage in bedside applications.
Confidence Intervals↗
Data compression: effect on diagnostic accuracy in digital chest radiography.
High-resolution digital images make up very large data sets that are relatively slow to transmit and expensive to store. Data compression techniques are being developed to address this problem, but significant image deterioration can occur at high compression ratios. In this study, the authors evaluated a form of adaptive block cosine transform coding, a new compression technique that allows considerable compression of digital radiographs with minimal degradation of image quality. To determine the effect of data compression on diagnostic accuracy, observer tests were performed with 60 digitized chest radiographs (2,048 x 2,048 matrix, 1,024 shades of gray) containing subtle examples of pneumothorax, interstitial infiltrate, nodules, and bone lesions. Radiographs with no compression, with 25:1 compression, and with 50:1 compression ratios were presented in randomized order to 12 radiologists. The results suggest that, with this compression scheme, compression ratios as high as 25:1 may be acceptable for primary diagnosis in chest radiology.
Humans↗
Evaluation of radiographs developed by a new ultrarapid film processing system.
The image quality of radiographs developed by a new ultrarapid processor was evaluated to determine if faster processing causes degradation in the image. The processor used was the Konica Super-Rapid SRX-501 model. Two films designed for this processor (Konica MGH-SR and MGL-SR) were processed in 45 sec and were compared with standard rapid processing in 90 sec of corresponding conventional films (Kodak TMG and OC). Rare-earth screens (Kodak Lanex Regular and Lanex Medium) used with the new and conventional films interleaved during angiographic studies or for phantom images were assessed for image quality. The basic imaging properties of the screen-film systems were examined by measuring (1) Hurter and Driffield curves, (2) modulation transfer functions by using the slit method, and (3) noise Wiener spectra. Subjective clinical assessment showed that the images obtained with ultrarapid processing were acceptable, with increased contrast and graininess. Hurter and Driffield curve measurements confirmed higher gradients. Modulation transfer function measurements were the same as for the conventional films. Noise Wiener spectrum measurements showed a 10% increase in noise for MGH-SR vs TMG film and a 30% increase for MGL-SR vs OC film. We conclude that acceptable image quality can be obtained using ultrarapid processing, with processing time approximately 60% that of conventional rapid processing. Potential applications include all areas in which rapid availability of the radiograph for interpretation is important. Although the processor studied was the first of its kind available, our evaluation indicates that the technology is available for a new class of ultrarapid processors.
Evaluation Studies as Topic↗
Comparison of imaging properties of a computed radiography system and screen-film systems.
To compare the diagnostic quality of images obtained with a computed radiography (CR) system based on storage phosphor technology with that obtained with conventional screen-film systems, a dual-image recording technique was devised. With this technique, a CR imaging plate is placed behind a screen-film system in a conventional cassette. This makes it possible to obtain two images simultaneously, one from each system, in a clinical examination with the same patient positioning, the same degree of patient motion, the same geometric unsharpness, and no additional exposure. The modulation transfer functions (MTFs) of the CR system with and without the dual-image recording technique were greater at low frequencies, but lower at high frequencies, that the MTFs of the screen-film systems used. The noise Wiener spectra of the CR images at the plane of the imaging plate were greater than those of the screen-film systems, but were comparable to those of the screen-film systems at the plane of the printed film due to the reduction in image size. Clinical chest images obtained with the dual-image recording technique appeared comparable, probably because of the image size reduction and the use of mild unsharp mask processing.
Humans↗
Development of a high quality film duplication system using a laser digitizer: comparison with computed radiography.
A high quality film-duplication system was developed in order to improve the image quality of duplicated radiographs and to recover improperly exposed films. The system consists of a laser film digitizer, a laser film printer, a workstation, and a magneto-optical disk. Radiographs are digitized by the laser digitizer, processed by the computer for image enhancement, and then printed on a film by the laser printer. A nonlinear density-correction technique is employed in recovering improperly exposed radiographs using the H&D curve of the screen-film system. Using the new duplication system in our department, the average recovery rate was over 80% for chest and abdominal films rejected due to over- or underexposed. The basic imaging properties of the duplication system were compared with those of a Computed Radiography (CR) system and a conventional screen-film system. For low spatial frequencies, the MTF of the CR system is superior to that of the digital duplication system; however, for high spatial frequencies, the MTF of the duplication system is superior. The noise in the duplication system is about half of that in the CR system.
Biophysical Phenomena↗