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Biomedical subjects

X X Gao

Publications and source records attributed to X X Gao.

4 recordsLinked to original sources
PubMed1992

T-kininogen, processing and functions.

Studies are presented which indicate that T-kininogen, the acute phase kininogen of the rat, could be a healing protein because of its properties as a cysteine protease inhibitor. Evidence is also presented that mRNA of T-kininogen synthesis may be a function of interleukin 6 production. A regulatory mechanism is postulated by which SH cofactors could determine if T-kinin is released or whether the T-kininogen molecule would remain intact. Evidence is also presented that T-kinin acts through kinin B2 receptors. No specific binding of bradykinin or T-kinin could be detected in rat heart preparations.

Acute-Phase Proteins↗
PubMed1991

[Relation between the clinical manifestations and electromyographic findings in motor neurone disease].

343 cases of motor neurone disease (MND) were examined with electromyography. The result showed EMG examination was of much vale in helping to ascertain an accurate diagnosis which clinically could be made in only about 1/4 of the series of cases. The ages of onset ranged from 4 months to 10 years with an average of 36.8 years. 56.8% under 40 years. There was a higher male preponderance, the male/female ratio being 3.2:1. It was 1.6:1 in a report from a western country. 123 cases showed only one limb involvement clinically while the EMG findings were also abnormal in the other three limbs. Fibrillation potentials were found to be at more than two sites in one muscle in 84.5% in this series, where as they occurred in 95-100% of the infantile and juvenile cases. Abundant fibrillation potentials were found in 37.1% of the cases within 3 years after the onset and in 13.6% in those with a longer duration. The increment of the mean duration of motor unit potential was 94.5% and that of the mean amplitude 91%. It seemed not necessary to emphasize giant potentials. The motor nerve conduction velocities (NCV) were normal in 95% while the sensory NCV were almost always normal (98%). All of the 3 cases tested with single fiber EMG showed an increment of jitter of 95-100% and a muscle fiber density of 2.95-3.65.

Amyotrophic Lateral Sclerosis↗
PubMed1991

[Amyotrophic lateral sclerosis: an analysis of 167 cases].

167 cases of amyotrophic lateral sclerosis treated in Peking Union Medical College Hospital were analyzed. There was a significant difference between some of the clinical features of amyotrophic lateral sclerosis in China and western countries. The age of onset in China was 10 to 20 years earlier than and the male to female ratio (4.6:1) was 2 times higher than those in the west. Average age of death was 47 years, being earlier than that in the west. Some specific clinical features for early clinical diagnosis were also discussed.

Adolescent↗