Biomedical subjects
Publications and source records attributed to X Zuo.
Hyaluronidase activities of testes and epididymides in rats were obviously inhibited by T4 po at dosage of 0.1 mg.kg-1/d for 7 weeks. T4 at dosage of 0.1 mg.kg-1/d for 3 weeks decreased GSH content in epididymides in rats. However, in vitro T4 at concentration of 10 micrograms/ml was found to exert no effect on the content of malondialdehyde in testis or H2O2 in testis and epididymis microsomes in rats.
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Treatment with 15-methyl PGF2 alpha methyl ester (PG05) resulted in termination of pregnancy and peristatic effects in mice. (+) PG05 is the active stereoisomer of racemic PG05. The therapeutic index of (+) PG05 was found to be closely similar to that of (+/-) PG05. Pregnancy of ovariectomized rats given progesterone and estrone was maintained normally. PG05 was shown to have no effect on the gestation of ovariectomized rats receiving progesterone and estrone injection. PG05 at a concentration of 20 micrograms/ml reduced cAMP secretion of rat luteal cells in response to hCG in vitro. PG05 at concentration of 10 and 20 micrograms/ml also exerted an inhibitory effect on 8 Br-cAMP-stimulated progesterone production. These results suggest that in luteal cells PG05 inhibits steroidogenesis at the steps of gonadotropin-stimulated cAMP formation and cAMP-induced progesterone production.
Early pregnancy factor (EPF) was purified from the pooled sera of 210 pregnant women at 3-8 weeks of gestation. Sera from healthy nonpregnant women were used as control. The samples (G-II, G-III and G-IV) obtained from pregnant women had EPF activity but no HCG activity. Polyacrylamide gel electrophoresis showed that the major bands in pregnant G-III and G-IV were at similar positions in tube gels. The results of SDS-PAGE showed 3 bands in pregnant G-IV: 57.0 kD, 38.0 kD and 19.0 kD. The basic active form of EPF may be a small peptide of 19.0 kD. The isoelectric points of pregnant G-IV were 6.45 and 8.20.