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Xian-hao Xu

Publications and source records attributed to Xian-hao Xu.

6 recordsLinked to original sources
PubMed2004

[Neuropsychiatric symptoms in dementia and elderly people in the community: results from the Beijing Dementia Cooperative Study].

OBJECTIVE: To determine the prevalence of neuropsychiatric symptoms in dementia and normal elderly people living in the Chinese community of Beijing. METHODS: A cross-sectional study derived from the Beijing Dementia Cooperative Study was carried out a population survey was carried out on a total of 1540 participants aged 65 years and older living in Beijing city and rural areas. All the individuals and 373 demented elderly people completed a series of neuropsychological examination and the Neuropsychiatric Inventory (NPI). RESULTS: Among the dementia participants, 49.33% had exhibited neuropsychiatric symptoms (35.66% rated as clinically significant), in which 80.4% reported 2 or more disturbances, with depression (23.86%), apathy (21.72%) and anxiety (20.38%) being most common. Of the 1540 normal individuals, 18.25% of them exhibited neuropsychiatric symptoms (6.49% rated as clinically significant), in which 53% reported 2 or more disturbances, with sleepless (10%), depression (8.9%) and anxiety (6.97%) being the most common. CONCLUSION: To our knowledge, this was the first multi-center study on neuropsychiatric disturbances in dementia and cognitive normal elderly people. Neuropsychiatric symptoms occurred mainly in persons with dementia and of clinical severity. Though the neuropsychiatric disturbances reported in cognitive normal individuals were lower and less serious compared to dementia, they should not be neglected. These finding suggested that a screening programme focusing on identifying these symptoms should be included in the physician's diagnostic tools for dementia.

Aged↗
PubMed2003

[Phrenic radix conduction time in inflammatory demyelinating polyneuropathy patients].

OBJECTIVE: To investigate the features and application of phrenic radix conduction time (PRCT) in inflammatory demyelinating polyneuropathy (IDP) patients. METHODS: Distal motor latency (DML) was recorded by stimulating phrenic nerve electrically and phrenic nerve root magnetically in 20 IDP patients with surface electrodes at intercostal space. The difference of the two DML was calculated and compared with those recorded previously from 61 sides in 31 healthy control subjects. RESULTS: PRCT of the IDP patients was longer than that of the controls, and it correlated with the severity of clinical dyspnea. The abnormal rate of PRCT was higher than the incidence of clinical dyspnea. CONCLUSIONS: PRCT could reflect the functional status of the spinal roots related to respiration in IDP patients at an electrophysiological level. It correlates well with the degree of clinical dyspnea. Its detection is helpful to find out the subclinical dyspnea in IDP patients.

Adolescent↗
PubMed2003

[The characteristics of enhanced gadolinium DTPA brain magnetic resonance images in 298 multiple sclerosis patients].

OBJECTIVE: To investigate the characteristics of enhanced brain magnetic resonance imaging (MRI) with gadolinium-DTPA (GD) in patients with multiple sclerosis (MS). METHODS: Brain enhanced MRI were studied in 186 patients with clinically definite multiple sclerosis. 298 MRI enhanced lesions were followed every 4 weeks and the study lasted 3 months to 2 years. RESULTS: Of the 298 enhanced MRI lesions 207 (69.5%) lasted less than 4 weeks, 251 (84.2%) 8 weeks, and 272 (91.3%) 12 weeks. There were 3 lesions lasting more than 2 years. Round, oval, ring form, arcuate, spotty, or irregular MRI GD enhanced lesions were found in our MS data. CONCLUSIONS: Most of the MRI GD enhanced lesions disappear in 4 weeks. Very few can last more than 2 years. So it is necessary to perform the GD enhanced MRI in 4 weeks for studying MS intracranial GD enhanced lesions. The DA enhanced MRI lesions in MS may be round, oval, ring form, arcuate, spotty or irregular.

Adolescent↗
PubMed2003

[Study on the mechanism of Alzheimer disease-related gene presenilin-1].

OBJECTIVE: To study the pathogenic mechanism of Alzheimer disease-related gene presenilin-1 (PS-1) mutation causing AD. METHODS: Four neural cells, including SY5Y cell, transgenic cells harboring PS-1 mutation, wild-type PS-1 and lipofectin were measured for neuronal Ca(2+) homeostasis and cell apoptosis. Intracellular calcium antagonist and antioxidant, such as Ginaton and nimodipine, were used in cultured neural cell and neuronal Ca(2+) level and cell apoptosis were examined. RESULTS: Elevation of intracellular calcium level and cell apoptosis induced by amyloid beta-peptide (Abeta) were enhanced in PS-1 mutation cell, as compared with others cells (P < 0.01). Intracellular calcium antagonist and antioxidant could inhibit apoptosis and decrease intracellular calcium level for PS-1 mutation (P > 0.05). There was significant correlation between the percentage of apoptosis and intracellular calcium level for PS-1 mutation. CONCLUSIONS: The pathogenic mechanism of PS-1 gene mutation causing AD was PS-1 mutation enhancing apoptosis by intracellular calcium overload. Intracellular calcium blocker and antioxidant could decrease intracellular calcium overload and inhibit apoptosis.

Aged↗