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Xiaofan Wang

Publications and source records attributed to Xiaofan Wang.

2 recordsLinked to original sources

Consensus in a heterogeneous influence network.

We consider a dynamical network model in which a number of agents all move on the plane with the same constant absolute velocity. At each time step, each agent's direction is updated as the average of its direction plus the directions of other agents who can influence it. The influencing capability of each agent is represented by its influencing radius, which is randomly chosen according to a power-law distribution with a scaling exponent between 2 and infinity. As the value of the scaling exponent decreases, the radius distribution becomes more heterogeneous and the network becomes much easier to achieve direction consensus among agents due to the leading roles played by a few hub agents. Furthermore, almost all agents will finally move in the same desired direction in a strong heterogeneous influence network, if and only if a small fraction of hub agents can be controlled to move in the desired direction. These results also reflect the "robust yet fragile" feature of a heterogeneous influence network.

Journal Article↗

Study on interaction between microtubule associated protein tau and prion protein.

Microtubule-associated protein tau is considered to play roles in many neurodegenerative diseases including some transmissible spongiform encephalopathies. To address the possible molecular linkage of prion protein (PrP) and tau, a GST-fusion segment of human tau covering the three-repeat region and various PrP segments was used in the tests of GST pull-down and immunoprecipitation. We found tau protein interacted with various style prion proteins such as native prion protein (PrPc) or protease-resistant isoform (PrPSc). Co-localization signals of tau and PrP were found in the CHO cell tranfected with both PrP and tau gene. The domain of interaction with tau was located at N-terminal of PrP (residues 23 to 91). The evidence of molecular interactions between PrP and tau protein highlights a potential role of tau in the biological function of PrP and the pathogenesis of TSEs.

Animals↗