Biomedical subjects
Publications and source records attributed to Xiaoquan Yao.
[reaction: see text] A highly efficient annulation of phenols and naphthols with dienes was developed by using a combination of AuCl(3)/AgOTf as catalyst. The annulation generated various benzofuran derivatives under mild conditions rapidly.
[reaction: see text] A highly efficient alkynylation-cyclization of terminal alkynes with ortho-alkynylaryl aldehydes leading to 1-alkynyl-1H-isochromenes was developed by using a gold-phosphine complex as catalyst in water. The reaction was dually promoted by an electron-donating phosphine ligand and water and was chelation-controlled.
[reaction: see text] A phosphine ligand served as a remarkable chemo-switch for the silver-catalyzed reaction of alkynes with aldehydes in the presence of amines in water. Exclusive aldehyde-alkyne-amine coupling product was observed in the absence of phosphine, whereas in the presence of a phosphine ligand, exclusive aldehyde-alkyne coupling product was obtained.
[reaction: see text] A highly efficient inter- and intramolecular addition of 1,3-diketone/beta-ketoester to alkenes was developed by using silver catalysts. Silver triflate shows the highest catalytic activity. The reaction is reversible through the cleavage of a carbon-carbon bond by silver at an elevated temperature.
A highly efficient intermolecular addition of 1,3-diketones to alkenes catalyzed by AuCl3/AgOTf was developed. A mechanistic rationale for the reaction has been proposed via a alpha-C-H activation.