Biomedical subjects

Xiaorong Chen

Publications and source records attributed to Xiaorong Chen.

7 recordsLinked to original sources

PubMed2025

MNMO: discover driver genes from a multi-omics data based-multi-layer network.

MOTIVATION: Cancer as a public health problem is driven by genomic variations in "cancer driver" genes. The identification of driver genes is critical for the discovery of key biomarkers and the development of personalized therapy. RESULTS: We propose a prediction method MNMO: a multi-layer network model based on multi-omics data. MNMO firstly constructs a dynamically adjusted four-layer network composed of miRNAs and three kinds of genes with different features. Then three kinds of scores, i.e. control capacity, mutation score, and network score, are devised and calculated by harmonic mean to produce the integrated gene score. Experiments were performed on three kinds of real cancer data to compare the identification performance of method MNMO with that of six state-of-the-art ones. The results indicate that method MNMO presents the best identification performance under most circumstances. The genes prioritized by method MNMO not only have a better match to the benchmark ones than those identified by the other methods, but also are all associated with the development and progression of cancers. In addition, some extended versions of method MNMO can further achieve better performance on most evaluation metrics for some specific datasets. They may be more conducive to identifying tissue-specific genes, which has been verified through a number of experiments. AVAILABILITY AND IMPLEMENTATION: The source code and the R package "MNMO" are available at https://github.com/Zheng-D/MNMO. The dataset and code are archived at https://doi.org/10.5281/zenodo.14969986.

Humans↗

PubMed2005

Dornase alfa reduces air trapping in children with mild cystic fibrosis lung disease: a quantitative analysis.

PURPOSES: To evaluate quantitative air trapping measurements in children with mild cystic fibrosis (CF) lung disease during a 1-year, double-blind, placebo-controlled, recombinant human deoxyribonuclease (rhDNase) [dornase alfa] intervention trial and compare results from quantitative air trapping with those from spirometry or visually scored high-resolution CT (HRCT) scans of the chest. MATERIALS AND METHODS: Twenty-five children with CF randomized to either daily rhDNase or placebo aerosol were evaluated at baseline, and at 3 months and 12 months by spirometer-triggered HRCT and spirometry. Outcome variables were percentage of predicted FVC, FEV1, and forced expiratory flow, midexpiratory phase (FEF(25-75%)); total and subcomponent visual HRCT scores; and quantitative air trapping measurements derived from chest HRCT images. RESULTS: At baseline, there were no statistical differences between groups in any of the variables used as an outcome. After 3 months of treatment, both groups had improvements in percentage of predicted FEV1 and FEF(25-75%), and total HRCT visual scores. In contrast, the rhDNase group had a 13% decrease in quantitative air trapping from baseline (severe air trapping [A3]), compared to an increase of 48% in the placebo group (p = 0.023). After 12 months, both groups had declines in percentage of predicted FVC and FEV1, but the rhDNase group retained improvements in percentage of predicted FEF(25-75%) and quantitative air trapping. The mucus plugging and total HRCT visual scores were also improved in the rhDNase group after 12 months of treatment, with and without significant differences between groups (p = 0.026 and p = 0.676). Quantitative air trapping (A3) remained improved in the rhDNase group (- 15.4%) and worsened in the placebo group (+61.3%) with nearly significant differences noted between groups (p = 0.053) after 12 months of treatment. CONCLUSIONS: Quantitative air trapping is a more consistent sensitive outcome measure than either spirometry or total HRCT scores, and can discriminate differences in treatment effects in children with minimal CF lung disease.

Air↗

PubMed2005

[Dynamics of water retaining capacity and chlorophyll content of two-line hybrid rice during heading-grain filling stage and their relations with grain yield].

The study with 25 two-line hybrid rice strains showed that their water retaining capacity was different with their combinations. On the whole, the water content in leaf and stem-sheath decreased during heading-grain filling stage, while that in panicle increased first and then decreased, with a peak at 7th day after heading. Stem-sheath was the main organ for water retaining. The correlation of panicle yield with both leaf and stem-sheath water content was positive at the 1st day after heading but became negative later, and that with whole stem-plant water content was positive after heading. The chlorophyll content of the two-line hybrids increased first and then decreased, with a peak at the 7th day after heading. Comparing with normal rice (male parent), the chlorophyll content of most two-line hybrids was lower, and the decreasing rate was faster than that of normal rice after heading. For two-line hybrid rice breeding, it should preferentially consider to select those hybrids which have a clearer dominance of plant water retaining capacity and a higher chlorophyll content at earlier and middle heading-grain filling stage, and an obvious dry matter transportation from leaf and stem-sheath at later heading-grain filling stage. For two-line hybrid rice planting, it should not only pay attention to the supply of water and nutrients, especially nitrogen at earlier and middle heading-grain filling stage, but also control nitrogen and water in time to prevent leaf green clinging and to promote dry matter transportation from leaf and stem-sheath to grain at later heading-grain filling stage.

Biomass↗

PubMed2004

Dendritic relationship between starburst amacrine cells and direction-selective ganglion cells in the rabbit retina.

We investigated the dendritic relationship between starburst amacrine cells (SAs) and morphologically and physiologically characterized ON and ON-OFF direction-selective ganglion cells (DSGCs) in the rabbit retina. ON and ON-OFF DSGCs were found to exhibit tight dendritic cofasciculation with the SA plexus, visualized by immunolabelling of the vesicular acetylcholine transporter (VAChT). The degree of cofasciculation of both types of DSGC dendrites and SA plexus was found to be significant, unlike the relationship between non-DS cells and the SA plexus, which was close to chance distribution. No difference in the degree of cofasciculation in different regions of the DS dendritic field was observed. Individual SAs intracellularly injected both on the 'preferred' and 'null' side of the DSGCs showed the same degree of cofasciculation with the DSGCs. Therefore, the computation of motion direction is unlikely to result from apparent asymmetry in geometric proximity between SAs and DSGCs. Highly selective synaptic connections between SAs and DSGCs are necessary.

Amacrine Cells↗

PubMed2003

Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties.

A series of unique indazoles and pyridoindolones have been rationally designed and synthesized as novel classes of cannabinoid ligands based on a proposed bioactive amide conformation. This has led to the discovery of the novel indolopyridone 3a as a conformationally constrained cannabinoid ligand that displays high affinity for the CB2 receptor (K(i)(CB2) = 1.0 nM) and possesses antiinflammatory properties when administered orally in an in vivo murine inflammation model.

Administration, Oral↗

PubMed2003

[Response of indica rice in two genic male-sterile lines to temperature and photoperiod].

Investigations on the fertility conversion of two photoperiod- and temperature sensitive genic male-sterile lines Zheda 247S and Peiai 64s under natural conditions in Hangzhou showed that there was a little impact of photoperiod on their fertility expression, while temperature was the main factor. Among daily mean temperature, daily maximum temperature and daily minimum temperature, the last one had the most significant correlation with the fertility. The temperature sensitive stage of Zheda 247S and Peiai 64S was 318 and 621 days before heading, the critical temperature of their fertility conversion was 25.28 and 25.66 degrees C, and the critical date was September 19th and September 25th, respectively. Compared to Peiai 64S, Zheda 247S had a more evident fertility conversion, its sterility was more complete and its self-setting percentage was higher at fertile stage, and the duration of the fertile stage was longer. Zheda 247S could be reproduced in Hangzhou.

Oryza↗

PubMed2002

C-3 Amido-indole cannabinoid receptor modulators.

C-3 Amido-indoles were found to selectively bind to the CB2 receptor. SAR studies led to optimized compounds with excellent in vivo potency against LPS induced TNF-alpha release in murine models of cytokine production.

Amides↗