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Xuedong Yan

Publications and source records attributed to Xuedong Yan.

5 recordsLinked to original sources

Analyses of rear-end crashes based on classification tree models.

OBJECTIVE: Signalized intersections are accident-prone areas especially for rear-end crashes due to the fact that the diversity of the braking behaviors of drivers increases during the signal change. The objective of this article is to improve knowledge of the relationship between rear-end crashes occurring at signalized intersections and a series of potential traffic risk factors classified by driver characteristics, environments, and vehicle types. METHODS: Based on the 2001 Florida crash database, the classification tree method and Quasi-induced exposure concept were used to perform the statistical analysis. Two binary classification tree models were developed in this study. One was used for the crash comparison between rear-end and non-rear-end to identify those specific trends of the rear-end crashes. The other was constructed for the comparison between striking vehicles/drivers (at-fault) and struck vehicles/drivers (not-at-fault) to find more complex crash pattern associated with the traffic attributes of driver, vehicle, and environment. RESULTS: The modeling results showed that the rear-end crashes are over-presented in the higher speed limits (45-55 mph); the rear-end crash propensity for daytime is apparently larger than nighttime; and the reduction of braking capacity due to wet and slippery road surface conditions would definitely contribute to rear-end crashes, especially at intersections with higher speed limits. The tree model segmented drivers into four homogeneous age groups: < 21 years, 21-31 years, 32-75 years, and > 75 years. The youngest driver group shows the largest crash propensity; in the 21-31 age group, the male drivers are over-involved in rear-end crashes under adverse weather conditions and the 32-75 years drivers driving large size vehicles have a larger crash propensity compared to those driving passenger vehicles. CONCLUSIONS: Combined with the quasi-induced exposure concept, the classification tree method is a proper statistical tool for traffic-safety analysis to investigate crash propensity. Compared to the logistic regression models, tree models have advantages for handling continuous independent variables and easily explaining the complex interaction effect with more than two independent variables. This research recommended that at signalized intersections with higher speed limits, reducing the speed limit to 40 mph efficiently contribute to a lower accident rate. Drivers involved in alcohol use may increase not only rear-end crash risk but also the driver injury severity. Education and enforcement countermeasures should focus on the driver group younger than 21 years. Further studies are suggested to compare crash risk distributions of the driver age for other main crash types to seek corresponding traffic countermeasures.

Acceleration↗

Characteristics of rear-end accidents at signalized intersections using multiple logistic regression model.

Multi-vehicle rear-end accidents constitute a substantial portion of the accidents occurring at signalized intersections. To examine the accident characteristics, this study utilized the 2001 Florida traffic accident data to investigate the accident propensity for different vehicle roles (striking or struck) that are involved in the accidents and identify the significant risk factors related to the traffic environment, the driver characteristics, and the vehicle types. The Quasi-induced exposure concept and the multiple logistic regression technique are used to perform this analysis. The results showed that seven road environment factors (number of lanes, divided/undivided highway, accident time, road surface condition, highway character, urban/rural, and speed limit), five factors related to striking role (vehicle type, driver age, alcohol/drug use, driver residence, and gender), and four factors related to struck role (vehicle type, driver age, driver residence, and gender) are significantly associated with the risk of rear-end accidents. Furthermore, the logistic regression technique confirmed several significant interaction effects between those risk factors.

Accidents, Traffic↗

The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse.

We evaluated the role of apolipoprotein E (apoE) in the clearance of neutral and negatively charged liposomes by hepatocytes in apoE-deficient mice. Negatively charged liposomes were cleared at identical rates in apoE-deficient and wild-type mice; neutral liposomes were cleared at a 3.6-fold slower rate in apoE-deficient mice. ApoE deficiency did not affect hepatic uptake of negatively charged liposomes but lowered that of neutral liposomes >5-fold. Hepatocyte uptake of neutral liposomes was reduced >20-fold in apoE-deficient mice; that of negatively charged liposomes remained unchanged. We conclude that uptake of neutral liposomes by hepatocytes is nearly exclusively apoE-mediated.

Animals↗

Liposome opsonization.

Adsorption of serum proteins to the liposomal surface plays a critical role in the clearance of liposomes from the blood circulation. In this review, we will discuss the role of the liposomal opsonins proposed so far in liposome clearance. Additional, related topics that will be addressed are the cell-surface receptors that might be involved in liposome elimination from the blood compartment and the effect of poly(ethylene glycol) (PEG) modification on prevention of liposome opsonization.

Animals↗