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Biomedical subjects

Y Al-Gindan

Publications and source records attributed to Y Al-Gindan.

8 recordsLinked to original sources
PubMed1989

Leishmaniasis.

Leishmaniasis is a parasitic infection caused by many species of the protozoa Leishmania. It occurs in endemic foci scattered throughout Asia, Africa, the Americas, and the Mediterranean countries. The disease is complex and may simulate many skin and systemic diseases. With awareness and suspicion, however, leishmaniasis is relatively easy to diagnose. Undiagnosed, it causes considerable morbidity and mortality. Treatment is often difficult, and current therapies leave much to be desired.

Acute Disease↗
PubMed1987

Clinical diagnosis of cutaneous leishmaniasis (oriental sore).

Cutaneous leishmaniasis (oriental sore) is characterized by slowly evolving inflammatory lesion(s) that are nodular, noduloulcerative, or ulcerative and that heal spontaneously with scar(s) in 3 to 12 months. In the course of a comprehensive study of cutaneous leishmaniasis due to Leishmania major in an endemic focus in Saudi Arabia, seven clinical features of diagnostic value were identified and their approximate frequency in a selected group of 475 patients was determined. These features were: exposed site location, 84%; pairing or clustering of lesions, 61.72%; skin crease orientation, 35.37%; volcanic nodules, 30.32%; satellite papules, 19.37%; subcutaneous nodules, 11.37%; and "iceberg" nodules, 4.63%. This information should serve the process of clinical diagnosis and may be relied upon when the procedures for parasite detection are negative or unavailable.

Humans↗
PubMed1987

Dissemination in cutaneous leishmaniasis. I. Subcutaneous nodules.

In a study of cutaneous leishmaniasis (CL) caused by Leishmania major in Saudi Arabia, 10% of the patients were found to have subcutaneous nodules (SCN). The SCNs were usually inconspicuous, painless, and proximal to the primary skin lesions; when multiple, they showed a "sporotrichoid" configuration or appeared as "beaded cords." Their number ranged from 1-16 (average 3 25 +/- 2.50; mean +/- 1 SD). In some patients, the SCNs seemed to be triggered by antileishmanial treatment. The clinical picture and pathologic findings suggest that SCNs in patients with CL represent lymphatic dissemination, a phenomenon not widely recognized.

Adolescent↗
PubMed1987

Peripheral nerve involvement in cutaneous leishmaniasis (Old World).

A review of 288 skin biopsy specimens from cutaneous leishmaniasis lesions caused by Leishmania major showed assorted nerve changes in 14 biopsy specimens (5%). Ten patients had perineural inflammatory cell infiltrate consisting of either lymphocytes or a mixture of lymphocytes, plasma cells, and macrophages. Four patients had inflammatory cell invasion of the nerves (neuritis), and in one of them the inflammation was granulomatous and associated with nerve destruction. Amastigotes were seen inside the nerves in two patients. Sensory testing of 50 consecutive patients with cutaneous leishmaniasis identified two patients with diminished sensations over the lesions.

Adult↗
PubMed1986

Immunohistological investigations in chronic cutaneous leishmaniasis in Saudi Arabia.

The distribution and numbers of IgG-, IgA-, IgM-, and lysozyme-positive cells were investigated by the immunoperoxidase method in paraffin-sections of 13 cases of chronic cutaneous leishmaniasis of low parasite load from Saudi Arabia. The majority of the peroxidase-positive plasma cells contained IgG, whereas the numbers of IgA+ and IgM+ plasma cells were not so numerous. Small groups of squamous epithelial cells showed immunoreactivity for IgG and IgA. Similar positive staining was observed extracellularly in the oedematous upper dermis, in the endothelial cells, and in the perivascular space. The activated macrophages showed strong and diffuse peroxidase staining for lysozyme, whereas epithelioid cells and multinucleated giant cells were negative or had finely granular and considerably weaker staining. It is suggested that humoral immunity also participates in the elimination of the parasites and an immunologically induced necrosis might be responsible for the ulceration of the skin in cutaneous leishmaniasis. It is also assumed that the lysozyme immunoreactivity can be a marker of the activation state of the macrophages.

Adolescent↗
PubMed1984

Cutaneous leishmaniasis in Al-Hassa, Saudi Arabia.

Cutaneous leishmaniasis of the classical noduloulcerative variety is endemic in Al-Hassa, Saudi Arabia. In a clinical study in which 56 Saudi patients and 66 non-Saudi patients were examined, it was found that the Saudi patients were considerably younger and had significantly milder disease compared with the non-Saudi patients.

Adolescent↗