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Y Arora

Publications and source records attributed to Y Arora.

8 recordsLinked to original sources
PubMed1999

Inhibition of the anti-V3 loop response to a recombinant gp120SF2 vaccine by preexisting monoclonal antibody.

Our previous studies have shown that maternally transferred MAb 83.1 (Repligen), which recognizes the V3 loop of HIV-1SF2, inhibited the anti-V3 IgG response of offspring BALB/c mice immunized with rgp120SF2 (Chiron). To determine the mechanism of this epitope-specific inhibition, MAb 83.1 was directly administered intraperitoneally to 19-day-old BALB/c mice, followed by immunization with rgp120SF2 in Freund's complete adjuvant at 21 days of age. The total serum anti-rgp120SF2 IgG response was not inhibited by preexisting MAb 83.1, but the anti-V3 IgG response was significantly inhibited (p < 0.03) 12 weeks after immunization. These results confirm epitope-specific inhibition of the immunodominant V3 loop and are consistent with epitope masking by preexisting antibody. Idiotypic dysregulation is unlikely since MAb 83.1 exposure was not required during the period of repertoire development in neonatal mice. Treatment with MAb prior to immunization may redirect the epitope specificity of an HIV vaccine response.

AIDS Vaccines↗
PubMed1998

HIV hyperimmune globulin or intravenous immune globulin inhibits response to an HIV vaccine.

The murine model was developed to assess the effects of maternally transferred HIV hyperimmune globulin or human intravenous immune globulin on the immunization of the offspring at 18-21 days of age with rgp 120SF2-complete Freund's adjuvant. Either HIV hyperimmune globulin or intravenous immune globulin was administered intraperitoneally to post-partum BALB/c mice and was transferred via milk to the offspring. Both HIV hyperimmune globulin and intravenous immune globulin inhibited the offspring anti-rgp 120SF2 IgG response to the vaccine. The HIV hyperimmune globulin inhibition persisted for 28 days after immunization while the intravenous immune globulin inhibition was still present at 63 days after immunization. In addition, the intravenous immune globulin had a more generalized immunosuppressive effect, inhibiting the IgG response to both rpg 120SF2 and an additional protein antigen, hen egg-white lysozyme. Effects of maternal or exogenously administered pre-existing antibody, including control antibodies (intravenous immune globulin), on the newborn response to HIV and other vaccines must be carefully evaluated when vaccine studies proceed in newborns.

AIDS Vaccines↗
PubMed1990

High prevalence of IgA rheumatoid factor in severe polyarticular-onset juvenile rheumatoid arthritis, but not in systemic-onset or pauciarticular-onset disease.

The presence of IgA rheumatoid factor (IgA-RF) has been correlated with severe joint disease in adult rheumatoid arthritis (RA), but IgA-RF has not been reported in juvenile rheumatoid arthritis (JRA). In the present study, IgA-RF was assayed by an enzyme-linked immunosorbent assay and was found in the sera of 14 of 24 children (58%) with active polyarticular JRA. The presence of IgA-RF correlated with the degree of functional disability. In contrast, IgA-RF was not found in the sera of systemic-onset disease patients, regardless of the degree of dysfunction. IgA-RF was detected in only 1 patient with pauciarticular disease, despite the fact that several patients in this group had severe disease. The presence of IgA-RF in polyarticular JRA did not correlate with serum IgA levels, but did correlate with the presence and the level of serum IgM-RF. Thus, the presence of IgA-RF appears to be specific for polyarticular JRA, and shows a correlation with severe disease in this group.

Adolescent↗
PubMedDate not supplied

Myelomatous pleural effusion.

Pleural effusion due to myelomatous involvement is rare. We are describing such a case who also had soft tissue extension from iliac bone with congestive heart failure.

Biopsy, Fine-Needle↗
PubMedDate not supplied

Miliary mottling in non-Hodgkins lymphoma.

Pulmonary parenchymal involvement and mediastinal lymphadenopathy are less common manifestations of non-Hodgkin's lymphoma as compared to Hodgkin's lymphoma. The pattern of pulmonary disease varies with histological type of non-Hodgkin's lymphoma. We are presenting an uncommon case of diffuse histiocytic lymphoma having miliary mottling who responded well to chemotherapy.

Humans↗