Y Ben David — Page 2 | PubMed Health

PubMed1984

High- and low-leukemogenic variants of the radiation leukemia virus (RadLV): immunogenic, suppressive and genetic properties in relation to leukemogenic activity.

C57BL/6 (B6) mice inoculated with the highly leukemogenic variant of the radiation leukemia virus (A-RadLV) develop suppressor cells capable of abrogating potential anti-tumor immunity in vitro and in vivo. Inoculation of B6 animals with the low-leukemogenic D-RadLV variant does not result in suppressor cell generation but induces antitumor reactive lymphocytes. A-RadLV and D-RadLV are not leukemogenic in BALB/c or (B6 X BALB/c)F1(F1) mice, and reactive but not suppressor lymphocytes could be demonstrated in F1 animals inoculated with either virus. Infectivity assays and fingerprint analysis revealed that A-RadLV and D-RadLV contain viruses with N and B tropism. In addition, thymoma cells induced by A-RadLV produced another virus with a fingerprint pattern containing X-MuLV elements. The possible implications of the different virus types on the immunogenic and leukemogenic properties of the RadLV variants are discussed.

Animals↗

PubMed1983

Early postoperative assessment of coronary artery bypass surgery using nuclear left ventriculography and atrial pacing.

Nuclear ventriculography (MUGA) was performed in 22 patients at rest and during the stress of right atrial pacing 6 to 8 days after coronary artery bypass surgery. In 7 patients the MUGA-atrial pacing test was positive for ischemia with chest pain, electrocardiographic ST depression and/or a decrease in global left ventricular ejection fraction of greater than 10%. All 7 patients subsequently developed angina pectoris with a positive treadmill test (performed at a median time of 14 months after operation). In 15 patients, the early postoperative MUGA-atrial pacing test was negative. In this group, 3 patients subsequently developed angina pectoris with a positive treadmill test in one. The sensitivity of the 'one week' early postoperative MUGA-atrial pacing in the identification of patients with residual myocardial ischemia was high (88% for positive GXT, p less than 0.0001; 70% for chest pain, p less than 0.005) with 100% specificity. The early postoperative MUGA scan was also useful in predicting later shortness of breath on exertion and there was a significant correlation between the early resting ejection fraction and the exercise capacity of the patient subsequently. The information obtained from an early postoperative MUGA-atrial pacing study may have far-reaching and important practical application in selecting patients for early recatheterization, possible fibrinolysis and/or possible cardiac reoperation.

Adult↗