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Biomedical subjects

Y Benoit

Publications and source records attributed to Y Benoit.

At least 73 records · Page 4Linked to original sources
PubMed1983

Pentasomy 21 characterizing spontaneously regressing congenital acute leukemia.

Pentasomy 21 was found to characterize the proliferating cells in a case of transient congenital acute leukemia (or congenital acute leukemia) with spontaneous remission. The patient was phenotypically normal, and cytogenetically no evidence could be found for the existence of a mosaic with a normal cell line and one with more than two No 21 chromosomes. The importance of these findings is discussed.

Acute Disease↗
PubMed1983

Comparison of chemotherapy with immunotherapy for maintenance of acute lymphoblastic leukemia in children and adults.

Two hundred and seventeen patients, 1-50 yr old, with acute lymphoblastic leukemia in complete remission were randomized to receive a 1-yr consolidation chemotherapy of either type P, comprising 7 different drugs, or type M, consisting of methotrexate interspersed with prednisone and vincristine. Thereafter, they were randomized a second time to receive a 4-yr maintenance of either chemotherapy or immunotherapy, comprised of allogeneic blasts and bacillus Calmette-Guérin (BCG). Consolidation P caused more toxicity than consolidation M. However, comparison between the consolidation therapies P and M showed no significant difference, neither for disease-free interval nor for duration of survival. Chemotherapy showed more lethal toxicity in adults than in children. Comparison between chemotherapy (C) and immunotherapy (I) as maintenance treatment showed a significant (p = 0.016) superiority of C for disease-free interval (DFI). The difference was even more pronounced (p = 0.009) in the group with less than 8 g/dl of hemoglobin (Hb) at diagnosis before therapy. On the other hand, for patients with more than 8 g/dl Hb at diagnosis, presumably those with T-ALL, no difference in DFI was seen. No difference has been seen so far between maintenance therapies I and C concerning the duration of survival. The patients who were receiving maintenance I when they relapsed and who were consequently retreated by chemotherapy, survived longer from relapse than those patients retreated for relapse while receiving maintenance C.

Adolescent↗
PubMed1982

[Familial erythrophagocytic lymphohistiocytosis. Report of five cases with cytophotometric study of nuclear DNA (author's transl)].

The authors report five cases of familial erythrophagocytic lymphohistiocytosis (F.E.L.H.). Two patients are brothers. One case is associated with a striking extramedullary hematopoiesis. A cytophotometric study of nuclear DNA in the histiocytes was performed in all cases. The histiocytes are diploid and there is no aneuploidy. These findings allow the authors to exclude the hypothesis of the tumoral nature of F.E.L.H. The data collected from the literature about the familial incidence of F.E.L.H. militate for an autosomal recessive transmission. The extramedullary hematopoiesis, which has not yet been reported in association with F.E.L.H., is probably due to the intense lymphohistiocytic infiltration of the bone marrow.

Child, Preschool↗
PubMed1981

[Skeletal changes in children with acute lymphoblastic leukemia].

Children with acute lymphoblastic leukemia frequently show skeletal changes. We examined 50 children with acute lymphoblastic leukemia with reference for skeletal pain as well as the nature and the degree of skeletal changes. 14 children had bone pain. The pain did not correlate with the roentgenographic findings. Some children had characteristic bone changes without bone pain. Roentgenographic findings were observed in 35 of the 50 children (70%). The major lesions observed were: transverse metaphyseal lucent bands, osteolytic lesions, osteosclerotic lesions, periosteal reaction and osteoporosis. Different pathologic findings in leukemia have been given a prognostic value. This was also done for the bony changes but the literature is not coherent on this point. In the group of 17 children with evident skeletal changes, 15 had a non B- non T-cell leukemia. Also the age of the patient, apart from the immunological cell type, seems to be an important factor in the incidence of initial skeletal roentgenographic findings.

Adolescent↗
PubMedDate not supplied

Repetitive analyses of P-glycoprotein in chronic myeloid leukaemia.

P-glycoprotein, a pump located in the plasma cell membrane, extrudes several clinically important drugs from the cell, and hence causes multidrug resistance. Reversing clinical drug resistance is possible by using agents that inhibit the activity of P-glycoprotein. We describe the results of sequential flow cytometric determinations of P-glycoprotein expression and activity in two patients suffering from acute lymphoblastic transformation of chronic myeloid leukaemia. Neither P-glycoprotein expression, nor its activity could be detected in the initial sample of the first patient. In the second patient, no P-glycoprotein expression was found at diagnosis. However, after chemotherapy containing P-glycoprotein substrates, a significant expression was found in both patients and the functional flow cytometric test was positive. In order to achieve an accurate selection of patients that might benefit from the clinical use of P-gp inhibitors, repeated analyses are indicated in each patient suffering from acute leukaemia, during the course of the illness.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMedDate not supplied

Outpatient and home parenteral antibiotic therapy (OHPAT) in low-risk febrile neutropenia: consensus statement of a Belgian panel.

Febrile neutropenia requires adequate antibiotic treatment. A subgroup of patients are only at low risk for complications and could be treated at home/as outpatients (OHPAT) after a short initial admission for work up. This position paper by a Belgian panel of experts presents criteria defining low-risk in febrile neutropenia, gives an overview of the existing experience and examines the present obstacles to a more widespread use of OHPAT in this country.

Anti-Bacterial Agents↗