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Biomedical subjects

Y C Choo

Publications and source records attributed to Y C Choo.

35 records · Page 2Linked to original sources
PubMed1984

Coexistent squamous cell carcinoma and adenocarcinoma of the uterine cervix.

The clinical and pathological features of 20 patients with coexistent squamous cell carcinoma and adenocarcinoma of the uterine cervix have been analyzed. Various combinations of in situ and invasive carcinomas were found. Located adjacent to each other and at times intermingling, these lesions probably originated from the subcolumnar reserve cells of the transformation zone. They are early lesions and may be precursors of adenosquamous and mucoepidermoid carcinomas of the cervix. The diagnosis of these double carcinomas depends upon being aware that the two entities may coexist in the same cervix. Treatment is conventional, and the prognosis is not worsened by the presence of the two types of neoplasms.

Adenocarcinoma↗
PubMed1984

Cervical-vaginal bacterial flora in patients with cervical carcinoma treated with irradiation and febrile morbidity during intracavitary radium therapy.

The cervical-vaginal bacterial flora of 57 patients with invasive carcinoma of the cervix were found to be identical to those reported in studies of different population groups, except for a lower frequency of anaerobic bacteria. Radiation suppressed significantly both the aerobic and anaerobic bacteria. Following 4,000 rads of external irradiation, 47.4% of the cervical cultures were bacteriologically sterile. During the first and second radium treatment, 21% and 25.5% of the patients respectively developed fever of 38 degrees C or more, the cause of which could not definitely be established. The significance of fever during radium treatment is discussed.

Adult↗
PubMed1984

Oral etoposide in gestational trophoblastic disease.

Ten patients with persistent or metastatic trophoblastic disease following molar pregnancy were treated with etoposide orally, administered on an outpatient basis. All patients achieved sustained biochemical remission. The mean duration of treatment was 8 weeks. The side effects were mild. The use of etoposide in patients resistant to conventional chemotherapy is discussed.

Adolescent↗
PubMed1984

High-dose cis-platinum in combination with adriamycin in the treatment of ovarian carcinoma.

Although promising potential of high dose cis-platinum in the treatment of ovarian carcinoma has been reported (6,7), a combination of adriamycin (60 mg/m2) and high dose cis-platinum (100 mg/m2) in 9 patients with advanced or recurrent ovarian carcinoma revealed no improved response compared to 13 patients receiving adriamycin (60 mg/m2) and cis-platinum (60 mg/m2). In addition to increased marrow toxicity, there is suggestion of synergism of cis-platinum to adriamycin cardiotoxicity. The efficacy of other agent/agents in combination with high dose cis-platinum should further be investigated.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

Fine needle aspiration of para-aortic and pelvic lymph nodes showing lymphangiographic abnormalities.

Fifty-six fine needle aspirations of lymphangiographically abnormal pelvic and para-aortic lymph nodes were performed in 50 patients at The University of Michigan between January 1, 1977, and May 31, 1980. Fine needle aspiration was used both in the initial evaluation of patients with gynecologic malignancies and in the investigation of persistent and recurrent malignant disease. The overall diagnostic accuracy of fine needle aspiration was 74.0%. Fine needle aspiration yielded diagnostic cytologic specimens; it was safe and well tolerated, and in some instances it permitted the diagnosis of lymph node metastasis without laparotomy.

Biopsy, Needle↗
PubMed1982

Multiple primary neoplasms of the ovary and uterus.

Multiple primary neoplasms arising in the ovary and uterus were analyzed in 55 patients: 49 synchronous and 6, metachronous. When they occurred synchronously, 74.5% of the ovarian carcinomas and 93.6% of the uterine carcinomas were stage I lesions. The endometrial carcinomas were invariably well differentiated and superficial. It was the stage of the ovarian carcinomas that determined the prognosis of these patients. Ways of their identification as separate neoplasms are discussed. The potential to develop further neoplasms in the gastrointestinal tract and breasts should be borne in mind.

Adenocarcinoma↗
PubMed1982

Fine needle aspiration in gynaecologic oncology.

One hundred and ten fine needle aspirations were performed on 73 patients with primary and recurrent gynaecological cancers. The sampling sites included superficial and retroperitoneal lymph nodes, soft tissue masses, liver, lungs, abdominal and pelvic masses, parametrium, thyroid and breast nodules. This relatively simple, safe and yet reliable technique can obviate the need for biopsies in most situations, and a more liberal use of aspiration cytology in gynaecological malignancies is advocated.

Biopsy, Needle↗
PubMed1980

Pelvic abscess complicating embolic therapy for control of bleeding cervical carcinoma and simultaneous radiation therapy.

Embolization therapy for control of bleeding has an important therapeutic role in gynecologic malignancies. This is the first report of a pelvic abscess as a sequela of embolic treatment for bleeding cervical cancer in a patient simultaneously receiving radiotherapy. Other complications of transcatheter embolizationare reviewed. Methods of preventing complications when embolization and radiation are combined are discussed.

Abscess↗
PubMed1980

Multiple primary neoplasms of the anogenital region.

The anogenital region, comprising the cervix, vagina, vulva, perineum, and anus, has the potential for the development of multicentric and multiple primary malignancies. Fifteen patients with 3 or more primary neoplasms in this region are presented. Awareness of the existence of these tumors as a regional disease and the possible long intervals between successive malignancies are emphasized. The presence of a vulvar neoplasm should arouse suspicion of a synchronous primary tumor elsewhere in the region. Conversely, sequential neoplasms occur more commonly after an initial cervical primary neoplasm and should be anticipated.

Adult↗
PubMed1979

Ileus of the colon with cecal dilatation and perforation.

Segmental dilatation of the colon without obstruction is an unusual but recognizable entity, distinct from mechanical obstruction and paralytic ileus. Cases of ileus of the colon with cecal dilatation following delivery and gynecologic surgery are collected from the literature, and 3 recent cases are presented: 1 following cesarean section and 2 following abdominal hysterectomy. The etiology of this condition is still obscure and the clinical features are deceptive. The occurrence of this entity in obstetric and gynecologic patients is by no means a rarity and warrants a familiarity with and early recognition of this entity on the part of the physician in order to avoid serious sequelae.

Adult↗
PubMedDate not supplied

Exfoliative cytology in the evaluation of interferon treatment of cervical intraepithelial neoplasia.

Local interferon injection in four patients with cervical intraepithelial neoplasia (CIN) regularly elicited progressive regression of the lesions. The response was observed with exfoliative cytology after each injection, guided by colposcopic examination. The cytologic changes showed a cytocidal effect mainly on the dyskaryotic cells, preceded by cellular degeneration not unlike that of nonspecific inflammation and accompanied by an increase in neutrophil infiltration. The cytologic response was closely correlated with partial or complete clinical regression based on the absence of viable or degenerated dyskaryotic cells in the cervical smears. Three patients showed complete clinical regression after treatment. One patient showed recurrent viable dyskaryotic cells when the dosage was reduced, and treatment was suspended temporarily although her lesion had regressed completely after five injections. Clinical recurrence was noted one week after viable dyskaryotic cells reappeared in her smears. These observations suggest that cytology may be a useful means of monitoring interferon treatment in CIN.

Adult↗