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Biomedical subjects

Y C Lai

Publications and source records attributed to Y C Lai.

At least 19 recordsLinked to original sources
PubMed2001

Noise-enhanced temporal regularity in coupled chaotic oscillators.

Existing works on coherence resonance, i.e., the phenomenon of noise-enhanced temporal regularity, focus on excitable dynamical systems such as those described by the FitzHugh-Nagumo equations. We extend the scope of coherence resonance to an important class of nonexcitable dynamical systems: coupled chaotic oscillators. In particular, we argue that, when a system of coupled chaotic oscillators in a noisy environment is viewed as a signal processing unit, the degree of temporal regularity of certain output signals may be modulated by noise and may reach a maximum value at some optimal noise level. Implications to signal processing in biological systems are pointed out.

Journal Article↗
PubMed2001

Dynamical mechanism for coexistence of dispersing species.

Dispersal of organisms may play an essential role in the coexistence of species. Recent studies of the evolution of dispersal in temporally varying environments suggest that clones differing in dispersal rates can coexist indefinitely. In this work, we explore the mechanism permitting such coexistence for a model of dispersal in a patchy environment, where temporal heterogeneity arises from endogenous chaotic dynamics. We show that coexistence arises from an extreme type of intermittent behavior, namely the phenomenon known as on-off intermittency. In effect, coexistence arises because of an alternation between synchronized and de-synchronized dynamical behaviors. Our analysis of the dynamical mechanism for on-off intermittency lends strong credence to the proposition that chaotic synchronism may be a general feature of species coexistence, where competing species differ only in dispersal rate.

Animals↗
PubMed2001

Catastrophic bifurcation from riddled to fractal basins.

Most existing works on riddling assume that the underlying dynamical system possesses an invariant subspace that usually results from a symmetry. In realistic applications of chaotic systems, however, there exists no perfect symmetry. The aim of this paper is to examine the consequences of symmetry-breaking on riddling. In particular, we consider smooth deterministic perturbations that destroy the existence of invariant subspace, and identify, as a symmetry-breaking parameter is increased from zero, two distinct bifurcations. In the first case, the chaotic attractor in the invariant subspace is transversely stable so that the basin is riddled. We find that a bifurcation from riddled to fractal basins can occur in the sense that an arbitrarily small amount of symmetry breaking can replace the riddled basin by fractal basins. We call this a catastrophe of riddling. In the second case, where the chaotic attractor in the invariant subspace is transversely unstable so that there is no riddling in the unperturbed system, the presence of a symmetry breaking, no matter how small, can immediately create fractal basins in the vicinity of the original invariant subspace. This is a smooth-fractal basin boundary metamorphosis. We analyze the dynamical mechanisms for both catastrophes of riddling and basin boundary metamorphoses, derive scaling laws to characterize the fractal basins induced by symmetry breaking, and provide numerical confirmations. The main implication of our results is that while riddling is robust against perturbations that preserve the system symmetry, riddled basins of chaotic attractors in the invariant subspace, on which most existing works are focused, are structurally unstable against symmetry-breaking perturbations.

Journal Article↗
PubMed2001

Analyses of transient chaotic time series.

We address the calculation of correlation dimension, the estimation of Lyapunov exponents, and the detection of unstable periodic orbits, from transient chaotic time series. Theoretical arguments and numerical experiments show that the Grassberger-Procaccia algorithm can be used to estimate the dimension of an underlying chaotic saddle from an ensemble of chaotic transients. We also demonstrate that Lyapunov exponents can be estimated by computing the rates of separation of neighboring phase-space states constructed from each transient time series in an ensemble. Numerical experiments utilizing the statistics of recurrence times demonstrate that unstable periodic orbits of low periods can be extracted even when noise is present. In addition, we test the scaling law for the probability of finding periodic orbits. The scaling law implies that unstable periodic orbits of high period are unlikely to be detected from transient chaotic time series.

Journal Article↗
PubMed2001

Experimental observation of generalized time-lagged chaotic synchronization.

We investigate, experimentally, synchronization in coupled chaotic oscillators in the presence of large parameter mismatches and identify a different phenomenon: generalized time-lagged synchronization. Specifically, we find that there can be a functional relation between time-lagged dynamical variables of the coupled oscillators in wide parameter regimes.

Journal Article↗
PubMed2001

Perturbed on-off intermittency.

A basic requirement for on-off intermittency to occur is that the system possesses an invariant subspace. We address how on-off intermittency manifests itself when a perturbation destroys the invariant subspace. In particular, we distinguish between situations where the threshold for measuring the on-off intermittency in numerical or physical experiments is much larger than or is comparable to the size of the perturbation. Our principal result is that, as the perturbation parameter increases from zero, a metamorphosis in on-off intermittency occurs in the sense that scaling laws associated with physically measurable quantities change abruptly. A geometric analysis, a random-walk model, and numerical computations support the result.

Journal Article↗
PubMed2001

Catalytic reduction of NO with NH3 over carbons impregnated with Cu and Fe.

Selective catalytic reduction (SCR) with NH3 remains as one of the most effective technologies controlling NOx emission from stationary sources. At low temperatures carbon exhibits higher catalytic activity in NOx reduction than conventional catalysts made of metal oxides or zeolites. In the present work, the rate of catalytic NO reduction conducted at 110-200 degrees C over mineral matter free carbon particles was found to be low, contrary to the findings reported in the literature. The activity of the carbon was significantly enhanced from impregnating it with nitrates of Cu and Fe. The carbon impregnated with Cu shows the highest activity. The affinity of these carbon catalysts toward NH3 and NO, as well as the tendency of the impregnated metal oxides toward reduction by carbon and H2, has an order identical to that of their activity in NO reduction. The high activity of the metal-loaded carbons was related to the combined catalytic effects of the carbon and the metal. It has been suggested on the basis of this study that the metal-carbon complexes may serve as the catalytic centers for oxygen transference from NO to NH3, which is essentially slow in the absence of the metal.

Air Pollutants↗
PubMed2001

Coherence resonance in coupled chaotic oscillators.

Existing works on coherence resonance, i.e., the phenomenon of noise-enhanced temporal regularity, focus on excitable dynamical systems such as those described by the FitzHugh-Nagumo equations. We extend the scope of coherence resonance to an important class of dynamical systems: coupled chaotic oscillators. In particular, we show that, when a system of coupled chaotic oscillators is under the influence of noise, the degree of temporal regularity of dynamical variables characterizing the difference among the oscillators can increase and reach a maximum value at some optimal noise level. We present numerical results illustrating the phenomenon and give a physical theory to explain it.

Journal Article↗
PubMed2001

Experimental observation of superpersistent chaotic transients.

We present the first experimental observation of superpersistent chaotic transients. In particular, we investigate the effect of noise on phase synchronization in coupled chaotic electronic circuits and obtain the scaling relation that is characteristic of those extremely long chaotic transients.

Journal Article↗
PubMed2001

Dynamical mechanism for coexistence of dispersing species without trade-offs in spatially extended ecological systems.

Most prior studies on the role of dispersal in the coexistence of competing species have emphasized the need for trade-offs between competitive and colonizing abilities for coexistence. Theoretical studies of the evolution of dispersal recently have revealed an alternative mechanism for the coexistence of species differing solely in dispersal rates in spatially extended systems. We present an analysis and numerical evidence indicating that chaotic synchronism, occurring in an extremely intermittent form, is an important feature of the spatiotemporal variation in fitness required for the coexistence of species without trade-offs.

Animals↗
PubMed2001

Regular dynamics of low-frequency fluctuations in external cavity semiconductor lasers.

It is commonly believed that the dynamics responsible for low-frequency fluctuations (LFF's) in external cavity semiconductor lasers is stochastic or chaotic. A common approach to address the origin of LFF's is to investigate the dynamical behavior of, and the interaction among, various external cavity modes in the Lang-Kobayashi (LK) paradigm. In this paper, we propose a framework for understanding of the LFFs based on a different set of fundamental solutions of the LK equations, which are periodic or quasiperiodic, and which are characterized by a sequence of time-locked pulses with slowly varying magnitude. We present numerical evidence and heuristic arguments, indicating that the dynamics of LFF's emerges as a result of quasiperiodic bifurcations from these solutions as the pumping current increases. Regular periodic solutions can actually be observed when (1) the feedback level is moderate, (2) pumping current is below solitary threshold, and (3) the linewidth enhancement factor is relatively large.

Journal Article↗
PubMed2001

Phase clustering and transition to phase synchronization in a large number of coupled nonlinear oscillators.

The transition to phase synchronization in systems consisting of a large number (N) of coupled nonlinear oscillators via the route of phase clustering (phase synchronization among subsets of oscillators) is investigated. We elucidate the mechanism for the merger of phase clusters and find an algebraic scaling between the critical coupling parameter required for phase synchronization and N. Our result implies that, in realistic situations, phase clustering may be more prevalent than full phase synchronization.

Journal Article↗
PubMed2001

Anesthesia for cerebral aneurysms: a comparison between interventional neuroradiology and surgery.

PURPOSE: To review the anesthetic management of patients with cerebral aneurysms during treatment in the interventional neuroradiology (INR) suite compared with in the operating room. METHODS: This was a retrospective chart review of 100 consecutive patients treated by endovascular coiling compared with 100 patients treated by surgical clipping of a cerebral aneurysm. Information compared and analyzed included demographics, pre-procedure medical history, neurological status including location and size of aneurysm, anesthetic management, complications and patient outcome. P < 0.05 was considered significant. RESULTS: Patients in the INR group were older (54 +/- 15 vs 49 +/- 12 yr), had a greater incidence of pre-procedure cardiorespiratory problems (55 vs 34 patients) and had more aneurysms located in the posterior fossa (68 vs 11) (P < 0.05). General anesthesia was used in all except seven INR patients who received conscious sedation. There were some differences in the anesthetic agents and techniques. There was less monitoring of INR patients; temperature (33 vs 99 patients), intraarterial catheter (22 vs 100), central venous catheter (4 vs 78), and evoked potential monitoring (0 vs 100). There were no differences in the incidence of documented complications or in patient outcome. CONCLUSION: There were some differences in the anesthetic management of patients undergoing endovascular treatment of a cerebral aneurysm compared with treatment in the operating room. The patients in the INR suite were sicker and somewhat older and they received less invasive monitoring, but the complication rate and outcome did not differ.

Adult↗
PubMed2001

Evaluation of immunomagnetic separation method for detection of Giardia for different reaction times and reaction volumes.

Immunomagnetic separation (IMS) has been specified as a standard method for the measurement of Giardia. In this study, Dynal IMS was evaluated on the basis of recovery efficiencies of Giardia cysts for various IMS operational conditions. The average recoveries for Giardia in deionized, treated and raw water samples were 82.6 +/- 12.2% (n = 6), 75.6 +/- 15.2% (n = 3), and 70.6 +/- 18.2% (n = 3), respectively. Significant changes in recovery were observed by altering the debris ratio and the debris components of water samples. Changing the reaction volume within the same vessel had no significant effect on cyst recovery efficiencies. However, prolonging the reaction time did increase recovery efficiencies.

Animals↗
PubMed2001

Observations on the application of the correlation dimension and correlation integral to the prediction of seizures.

The authors reexamine the correlation integral and the related correlation dimension in the context of EEG analysis with application to seizure prediction. They identify dependencies of the correlation integral and the correlation dimension on frequency and amplitude of the signal, which may result in a reinterpretation of the dynamic importance of these measures and may cast doubts on their predictive abilities for certain classes of seizures. The relevance, for clinical and research purposes, of the distinction between retrospective and prospective inference (prediction) is addressed briefly. The authors point to the need for further research, consisting of long time series, containing multiple seizures, and for the development of objective prediction criteria.

Cerebral Cortex↗
PubMed2001

Identification of genes induced in vivo during Klebsiella pneumoniae CG43 infection.

A novel in vivo expression technology (IVET) was performed to identify Klebsiella pneumoniae CG43 genes that are specifically expressed during infection of BALB/c mice. The IVET employed a UDP glucose pyrophosphorylase (galU)-deficient mutant of K. pneumoniae which is incapable of utilizing galactose and synthesizing capsular polysaccharide, as demonstrated by its low virulence to BALB/c mice and a white nonmucoid colony morphology on MacConkey-galactose agar. By using a functional galU gene as the reporter, an IVE promoter could render the galU mutant virulent while maintaining the white nonmucoid colony phenotype. A total of 20 distinct sequences were obtained through the in vivo selection. Five of them have been identified previously as virulence-associated genes in other pathogens, while another five with characterized functions are involved in regulation and transportation of nutrient uptake, biosynthesis of isoprenoids, and protein folding. No known functions have been attributed to the other 10 sequences. We have also demonstrated that 2 of the 20 IVE genes turn on under iron deprivation, whereas the expression of another five genes was found to be activated in the presence of paraquat, a superoxide generator.

Animals↗
PubMed2000

Identification of genes present specifically in a virulent strain of Klebsiella pneumoniae.

Klebsiella pneumoniae is a common cause of septicemia and urinary tract infections. The PCR-supported genomic subtractive hybridization was employed to identify genes specifically present in a virulent strain of K. pneumoniae. Analysis of 25 subtracted DNA clones has revealed 19 distinct nucleotide sequences. Two of the sequences were found to be the genes encoding the transposase of Tn3926 and a capsule polysaccharide exporting enzyme. Three sequences displayed moderate homology with bvgAS, which encodes a two-component signal transduction system in Bordetella pertussis. The rest of the sequences did not exhibit homology with any known genes. The distribution of these novel sequences varied greatly in K. pneumoniae clinical isolates, reflecting the heterogeneous nature of the K. pneumoniae population.

Bacterial Proteins↗