Biomedical subjects
Publications and source records attributed to Y Cabadi.
An automatized technique for the study of hemagglutination kinetics is described. It was used to differentiate between homozygous and heterozygous individuals in the Rh system. Other applications are proposed.
The agglutination percentages given by various erythrocytes with reference sera have been compared in blood samples from Kulamwos living in the Ivory Coast and of blood donors of the regional transfusion centre of Toulouse. The study of O, A, B and AB phenotypes shows: 1. in O Kulamwos a higher agglutination percentage with anti-H than in Toulousains; 2. in B Kulamwos a higher agglutination percentage with anti-B than in Toulousains; 3. in A Kulamwos a very marked frequency of A intermediate which can be classified in different categories due to the variability of their agglutination percentage with anti-A1 and anti-H sera.
The red blood cell antigens of the ABO system are not present in all the anthropïd Primates. The Chimpanzee, particularly, shows only the two genes A and O. The alpha-galactosyl transferase, present in the human sera of group B, has been used to fix a molecule of galactose on O red cells of Chimpanzee giving them a B specificity. If the B gene was present in the Chimpanzee it could consequently be expressed on the erythrocytes. This gene, probably present in an ancestor common to the anthropoïd apes and to Man disappeared in the Chimpanzee, perhaps at the origin of species.
Agglutination percentages of red blood cells from European and from three African populations (Twareg from Mali, Sara from Central African Republic, and Niokholonko from Senegal) in the ABO system have been compared. The results show a greater agglutinability of group O erythrocytes with anti-H sera, for African subjects than for Europeans. No significant difference was noted between African and European B subjects, except for the Niokholonko, whose agglutination percentage was slightly higher with anti-B. The study of group A disclosed a large number of Aint in all African populations studied. The AB African red cells seem to be less agglutinable with anti-A and anti-A1 sera than European ones; A and A1 antigens may be depressed by a strong B antigen.
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