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Y Carpentier

Publications and source records attributed to Y Carpentier.

At least 55 records · Page 3Linked to original sources
PubMed1976

[The place of modern nutritional techniques in the treatment of digestive fistulae (author's transl)].

Twenty-six patients with a digestive fistula have received a parenteral or enteral nutrition consisting of an elemental diet. They are separated into 2 groups according to good or bad vital prognosis of the desease treated conventionally. In 13 of the 18 patients with a poor prognosis, the nutritional techniques were started early: twelve were rapidly cured. In 5 patients of this group nutrition was started late, after one or many surgical failures and an important deterioration of the general status: only 2 were cured. These results agree with those of the literature; they show the advantages of the systematic use of these special types of nutrition in cases of digestive fistula and the importance of early use of these new methods.

Adolescent↗
PubMed1976

[Parenteral nutrition. Technique of long term central venous catheterization (author's transl)].

The authors compare two techniques of deep venous catheterization for long term total parenteral nutrition. From December 1, 1973 to April 30, 1974, 31 polyethylene catheters were placed by direct transcutaneous puncture of the subclavian or internal jugular vein in 18 patients. From Mayl, 1974 to March 30, 1975, 35 silicone rubber catheters were surgically placed by cutdown of the basilic vein, in 32 patients. The surgical technique has important advantages such as a safe technique, diminished local and generalized complications and the possibility of intermittent perfusion. Therefore the authors recommend the latter surgical technique for parenteral nutrition lasting 1 to 8 weeks.

Catheterization↗
PubMed1975

[Local and metastatic growth of Lewis lung carcinoma as a function of its transplantation site. Application to the study of the pharmacology of sulphadiazine triazene].

The presence of a local tumour and pulmonary metastases is studied after the administration of the Lewis Lung Carcinoma at different sites of transplantation. The intravenous administration routes, in the tail vein and in the portal vein, injections in the liver and in the muscle of the left hindleg are used. The injection in the tail vein induces pulmonary "metastases". The injection in the portal vein is followed by multiple tumours in the whole liver and pulmonary metastases. An unilobar hepatic tumour and early pulmonary metastases appear after transplantation in the liver. Intra-muscular injection gives a local tumour which can be weighed after amputation of the leg and pulmonary metastases. A test of treatment by Sulphadiazine Triazene points out a weak action on the primary tumour and a larger one on the metastases.

Animals↗
PubMedDate not supplied

Metabolic effects of arginine addition to the enteral feeding of critically ill patients.

BACKGROUND: Some studies have suggested that the addition of arginine to enteral feeding solutions may improve outcome in critically ill patients, but the mechanism is incompletely explained. In particular, the availability and utilization of arginine administered enterally is not well defined. METHODS: This prospective, randomized, double-blind, placebo-controlled study performed in a Department of Medicosurgical Intensive Care included 51 patients likely requiring long-term enteral feeding. Thirty-seven patients (57 +/- 7 years, SAPS II 33 +/- 6) completed the 7-day study, of whom 20 received the formula enriched with free arginine (6.3 g/L) and 17 received an isocaloric and isonitrogenous control solution. Arginine absorption was assessed from plasma arginine concentrations in serial samples. Three pathways of arginine utilization were explored: (1) the production of nitric oxide, assessed by the plasma concentration of nitrite/nitrate (NOx) and citrulline, and 24-hour urinary excretion of NOx; (2) the protein turnover, estimated by the phenylalanine concentrations; and (3) the activity of arginase, reflected by the ornithine concentration. RESULTS: The plasma concentrations of arginine and ornithine increased in the group fed with the enriched formula (from 55 +/- 9 micromol/L to 102 +/- 9 micromol/L and from 57 +/- 7 to 135 +/- 11 micromol/L, respectively, p < .05), but not with the control formula. There was no difference between groups in either NO production or phenylalanine concentration. CONCLUSIONS: Supplemental arginine in enteral feeding is readily absorbed, and mainly metabolized into ornithine, presumably by the arginase enzyme.

Arginase↗
PubMedDate not supplied

Response of primary tumour, spontaneous metastases and recurrence of Lewis lung carcinoma (3LL) to flavone acetic acid (FAA, LM975).

B6D2F1 mice bearing 3LL were more sensitive to FAA than control mice, the LD50 being 180 x 2 and 336 x 2 mg/kg respectively. At a dosage of 140 mg/kg, injected i.p. at day 4 and 11, FAA significantly decreased the primary tumour growth, the occurrence and the growth of spontaneous pulmonary metastases. The effect of two injections was dose-dependent on the primary tumour and metastases; the survival time was also dose-related. Combined with primary tumour ablation, FAA administered before any dissemination (at day 3) was more efficient against metastases than when it was injected after the end of the dissemination (i.e. after primary tumour ablation). When all treatment schedules were pooled, the number of mice without metastasis was significantly higher in treated than in control groups. The effect of FAA on recurrences was also notable.

Animals↗
PubMedDate not supplied

Effect of gallium at two phases of the CA 755 tumour growth.

GaCl3 efficiency was evaluated for mice mammary adenocarcinoma Ca-755 separately at two stages of tumour growth: the exponential and plateau phase. Two modalities of drug administration were evaluated: once only and twice a day for five days. Comparisons were made with the efficiency observed when saline liquid and cyclophosphamide were used. The comparisons between tumour shrinkages were carried out by non-parametric tests. GaCl3 was more often efficient for tumours at the exponential phase than for those at the plateau phase of growth. GaCl3 always appeared less efficient than cyclophosphamide. The treatment schedule did not result in any significant alteration of tumour regression.

Adenocarcinoma↗
PubMedDate not supplied

Postoperative duodenal fistulas. A report of 23 cases with emphasis on the surgical treatment by the Roux-en-Y operation.

A series of 23 patients-15 with a spontaneous postoperative duodenal fistula and 8 with a catheter duodenostomy fistula-admitted in both departments between 1974 and 1983, is reviewed. Overall mortality rate was 9%. Using conservative management and parenteral nutrition, spontaneous closure of the fistula was observed in 78% of the cases after an average duration of 33 days. Three patients with an intractable fistula were successfully managed by surgical internal drainage using a Roux-en-Y jejunal loop. Healing time of catheter duodenostomy fistulas was similar to that of spontaneous fistulas. Therefore, deliberate creation of such duodenal fistulas should be carefully considered. The Roux-en-Y operation is recommended for those fistulas that do not heal with conservative management. The latter technique could perhaps be used primarily for the closure of difficult duodenal stumps.

Adult↗
PubMedDate not supplied

Culture conditions modulate the effects of aclacinomycin A on growth, differentiation and apoptosis of HL60 cells.

The continuous incubation for several days of HL60 cells, in exponential growth, with aclacinomycin A (ACM) induces growth inhibition, necrosis, differentiation and apoptosis. Differentiation and apoptosis were assessed by optical microscopy (OM) and flow cytometry (FCM). ACM displayed dose-dependent effects, except for the differentiation induction, which was biphasic. Differentiation and apoptosis could also be induced after a 1 h ACM exposure only. The poor reproducibility of apoptosis induction led us to study the culture conditions described in the literature (without renewing the medium) where control cells are not growing exponentially during the 5 day incubation period. During kinetic studies with different ACM concentrations, the differentiation was detected earlier by FCM than by OM, while it was not the case for apoptosis. This induction appeared more reproducible when non optimal conditions of culture were used.

Aclarubicin↗