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Biomedical subjects

Y Coşkun

Publications and source records attributed to Y Coşkun.

11 recordsLinked to original sources
PubMed2001

Mediators of inflammation in children with type I diabetes mellitus: cytokines in type I diabetic children.

OBJECTIVES: Recent evidence favors primary role of cellular autoimmunity and its humoral mediators in pathogenesis and following Type I diabetes mellitus (DM). The present study was carried out to investigate serum concentrations of C-reactive protein (CRP), interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-alpha in children with type I DM. Potential role of lipid metabolism, glycemic control, body mass index (BMI) and disease duration were evaluated. DESIGN AND METHODS: Thirty-five children with type I DM and 30 age and gender matched nondiabetic controls were recruited for this study. RESULTS: Circulating IL-8 levels were elevated in children with type I DM (12.7 +/- 1.7 pg/mL) compared with nondiabetic controls (5.5 +/- 0.3 pg/mL) and the difference remained significant after adjustment for cofactors and covariates (p: 0.033). Although statistically insignificant serum CRP concentrations were slightly higher in diabetic children (p: 0.075). Serum TNF-alpha and IL-6 levels were comparable in diabetic and nondiabetic groups. However newly diagnosed (<1 yr) cases had higher TNF-alpha and IL-6 levels compared to cases with longer standing DM. In diabetic children BMI was independently associated with an increase in serum IL-8 levels. Serum CRP, lipids, apolipoproteins and glycemic control were not significant predictors of cytokine concentrations in children with type I DM. CONCLUSION: Circulating levels of IL-8 were elevated and were correlated with BMI in children with type I DM, hinting perhaps at adipose tissue as a site of production. Elevated systemic IL-6 and TNF-alpha were limited to newly diagnosed cases suggesting activation of the inflammatory immune response system at early stages of the disease.

Biomarkers↗
PubMedDate not supplied

Fatal infectious mononucleosis in a family.

Two male siblings, one aged five and a half months (SB), and the other aged six months (VB), with fatal infectious mononucleosis phenotype of the X-linked lymphoproliferative syndrome, which resulted in the death of both infants, are presented. Both patients had been healthy, one until the age of five and a half months, and the other until the age of six months. Then, they developed a maculopapular rash, hepatosplenomegaly and lymphadenopathy. In one sibling, the serum IgG level was low, the IgM and IgA levels were high, and the proportion of E-rosette forming cells (E-RFC) and in vitro proliferative response to PHA were normal. In the other sibling, however, the serum IgG level was normal, the IgM and IgA levels were high and the stimulation index for proliferative response to PHA was reduced due to increased spontaneous blastogenesis. Anti-EBV antibodies were negative in both siblings, except for the IgM anti-VCA in V.B. A lymph node specimen could be studied in one infant and was found to be positive for the EBV genome. Postmortem histopathological findings included the absence of cortico-medullary differentiation and identifiable Hassal's corpuscles in the thymus and depletion of T-dependent regions of lymph nodes and spleen in V.B. Atypical mononuclear cell infiltration was detected in the portal areas of the postmortem liver biopsy in S.B.

Humans↗
PubMedDate not supplied

Neutrophil and lymphocyte locomotion in patients with selective IgA deficiency.

Neutrophil chemotaxis was studied in 14 patients, twelve with selective and two with partial IgA deficiency. Twelve of the 14 patients were also evaluated for lymphocyte locomotion. Zymosan activated serum was used to stimulate cell migration, and Boyden chambers were used for both neutrophil and lymphocyte chemotaxis assays. Evaluation of the results of neutrophil and lymphocyte locomotion showed that chemotaxis to ZAS, random migration and chemotactic index values were not significantly different when comparing the patients with the controls.

Cell Movement↗
PubMedDate not supplied

Clinical and immunological evaluation of patients with selective IgA deficiency.

The clinical and immunological features of 14 patients including 12 with selective and two with partial IgA deficiency are presented. One patient was asymptomatic, six patients had allergic diseases, three patients had hematologic disorders and the remaining patients had chronic-recurrent infections. The IgG and IgM serum concentrations were high in four and two patients, respectively. Delayed hypersensitivity skin tests were applied to seven patients, and were found positive in all. E-rosette forming cells were within the normal range. In vitro lymphoblastic transformation with PHA was normal in all the patients, except for one. Two patients had no sIgA+ B cells. The percentage of CD+4 T cells was decreased in one patient and the percentage of CD+8 T cells was increased in another, both of whom had a low CD4/CD8 ratio. The heterogeneity of clinical and immunological features in these patients suggests that various mechanisms may be responsible for the immunopathogenesis of IgA deficiency.

Adult↗
PubMedDate not supplied

Kawasaki disease associated with gallbladder hydrops.

Kawasaki disease is an acute, febrile, systemic syndrome of unknown etiology which principally affects young children. We present a five-year-old boy, who developed an unusual finding, acute hydrops of the gallbladder, in addition to the characteristic signs and symptoms of Kawasaki disease. Clinical features of the disease and treatment regimens, including early administration of intravenous gamma globulin (IVGG), which prevents cardiac complications, are discussed.

Child, Preschool↗
PubMedDate not supplied

Whistling face (Freeman-Sheldon) syndrome in two siblings.

Two siblings with typical manifestations of whistling face (Freeman-Sheldon) syndrome (WFS) born to unaffected parents are presented. In Case 1, deep-set eyes, epicanthus, blepharophimosis, right lid ptosis, strabismus, anti mongoloid slant, small mouth, mask-like face, high-arched palate, nasal speech, dysphagia, kyphosis and minimal scoliosis were noted, while Case 2 displayed blepharophimosis, mask-like face, long philtrum, high-arched palate, scoliosis, bilateral post-axial polydactyly of the feet and pes varus. We corrected the blepharophimosis in Case 1 by bilateral canthotomy and canthoplasty. This syndrome is usually inherited as an autosomal dominant trait; however, some authors have reported an autosomal an autosomal recessive form of this syndrome similar to our cases. Nevertheless, this could be explained by genetic expression of the mutant gene.

Child↗
PubMedDate not supplied

Unusual malformations in occult spinal dysraphism.

Two cases of occult spinal dysraphism with different clinical symptoms, signs and congenital pathologies are presented. One had malformations including scoliosis, dermoid tumor, hydromyelia, diastematomyelia, dermal sinus, low conus, vertebrae anomalies and dextrocardia. The occurrence of dextrocardia in association with occult spinal dysraphism was found to be extremely unusual. The second case is presented in relation to the rarity of teratoma with dermal sinus and tethered cord in the lumbar area. Myelography, computed tomography, (CT), Myelo CT and magnetic resonance were used in making a diagnosis.

Abnormalities, Multiple↗
PubMedDate not supplied

Immunoglobulin isotypes and IgG subclasses in recurrent infections.

The frequency of major immunoglobulin isotype and IgG subclass deficiencies among 74 children aged six months to 14 years with recurrent infections was studied. All children had at least five to six episodes of respiratory tract infections, while recurrent diarrhea had occurred in eight. Two selective and six partial IgA deficiencies were detected. IgG4, IgG3 and IgG2 deficiencies, either isolated or combined, were found in 13, nine and one patient respectively. Among these there were two combined deficiencies of IgA + IgG4, three of IgA + IgG3, one of IgA + IgG2 + IgG4, one of IgG1 + IgG3 and two of IgG1 + IgG4. There was one patient with panhypogammaglobulinemia. Our results, similar to those of other studies, showed that the occurrence of the Ig isotype, particularly subclass deficiencies, is not uncommon in children with frequent infections.

Adolescent↗