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Y Costes

Publications and source records attributed to Y Costes.

23 records · Page 2Linked to original sources
PubMed1986

[Action of ifenprodil tartrate in obliterative arteriopathies of the lower limbs. Combined studies using proximal blood flow and distal transcutaneous oxygen pressure].

A simultaneous analysis of both the variations of the flow in the stenosis artery and the distal PO2, was carried out during an injection of an alpha-blocker: the Tartrate d'Ifenprodil, on twenty-five patients afflicted with occlusive disease of the lower limbs requiring surgery. The measurements were taken under general anaesthesia, before any surgical operation, the hemodynamic and ventilatory balance being monitored by radial manometry and arterial gas analysis. We observe an increase of proximal arterial flow and at the same time an improvement of the distal TcPO2. Moreover, the variations of microcirculation flow measured by TcPO2 are correlated with proximal flow variations, this relation: delta TcPO2 = K delta Q + A is more true in the first and the second stages of Fontaine. With the same (Tartrate d'Ifenprodil) posology, the distal benefit measured by transcutaneous oximetry is less important in advanced stages compared with other stages (everything else being equal). The transcutaneous measurement of the distal oxygen pressure, allows an objective view of microcirculatory improvement obtained by a vasoactive substance (ifenprodil tartrate) considering the specific nature of each patient arteriopathy.

Adult↗
PubMedDate not supplied

Effect of cytidine diphosphate choline on anoxia tolerance of cultured myocardial cells.

Three series of cultured Wistar rat heart cells (10 treated and 10 controls x 3) were examined with a laser contraction-meter in a special chamber for anoxia to determine whether cytidine diphosphate choline (CDPC), a membrane phospholipid precursor, can protect against total oxygen deprivation. Heart rate and force of contraction (inotropism) were monitored during a 40-minute period of hypoxia. CDPC in a concentration of 142 micrograms/ml-1 was added to the culture medium only during the anoxia period in series I, during the 3 days of culture in series II, and during the 3 days of culture and the 40-minute hypoxia period in series III. In series I, inotropism decreased by 21% versus 55% in control group (P less than 0.05). In series II, inotropism decreased by 25% versus 43% in control group (P less than 0.05). In series III, inotropism decreased by 22% versus 44% in control group (P less than 0.05). Compared with control cells, cells treated with CDPC during anoxia maintained a significantly greater inotropic state. The effect is greatest if the cells are weak, as in series I. CDPC may be a useful component of the cardioplegic mixture during cardiopulmonary bypass and in the treatment of myocardial ischemia.

Animals↗