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Biomedical subjects

Y D Sibley

Publications and source records attributed to Y D Sibley.

5 recordsLinked to original sources
PubMed1986

Surgical correction of isolated persistent left superior vena cava draining to left atrium in a neonate.

A one day old baby who presented with cyanosis was later shown to have an isolated persistent left superior vena cava draining into the left atrium with hypoplastic right superior vena cava. This extremely rare anomaly was diagnosed by cardiac catheterisation at one week. Surgical correction at two weeks, by anastomosis of the innominate vein to the right atrium and by ligation of the left superior vena cava at its junction with the left atrium, was successful. This patient is the youngest case in which successful surgical correction of this isolated anomaly has been reported.

Echocardiography↗
PubMed1986

Surgical correction of anomalous origin of right pulmonary artery from aorta in a four day old neonate.

A two day old neonate presented with cyanosis. The echocardiogram was misinterpreted as showing transposition of the great arteries. Cardiac catheterisation was performed the next day and showed anomalous origin of the right pulmonary artery from the aorta. Surgical correction at the age of 4 days was successful. At the age of nine months the patient was symptom free with "normal" cardiac anatomy. This patient is the youngest case to have successful correction of this anomaly. The initial misinterpretation of the echocardiogram could have had serious consequences if balloon atrial septostomy had been attempted.

Aorta↗
PubMed1982

The influence of behavioural state on the cardiovascular system of newborn lambs.

The influence of behavioural state, as defined by clinical observation and EEG recording, on cardiac output, heart rate, stroke volume and blood pressure was investigated in eight newborn lambs during the first 2 weeks of life. Cardiac output was measured using the technique of thermodilution. Highest mean value (mean +/- SEM) of cardiac output was found in the very alert awake state in week 1, 271 +/- 16 ml/min per kg. Other values were significantly lower; quiet sleep, 173 +/- 4 ml/min per kg; rapid-eye-movement sleep, 191 +/- 7 ml/min per kg; quiet awake, 174 +/- 3 ml/min per kg; alert awake, 180 +/- 5 ml/min per kg. Similar values were found in week 2. These values of cardiac output were lower than those previously reported for newborn lambs except in the very alert awake state. Heart rate was significantly lower during sleep than in the awake states in week 1. The heart rate was found to be significantly higher in all states except the very alert awake state in week 2 compared with week 1. Stroke volume was significantly higher in rapid-eye-movement sleep, 1.08 +/- 0.06 ml/kg, and in the very alert awake state, 1.16 +/- 0.09 ml/kg, compared with the other states in week 1, but only in the very alert awake state in week 2. Blood pressure was highest in the very alert awake state in both weeks. These findings demonstrate that behavioural state has a very significant influence on the cardiovascular system during newborn life in lambs, particularly on cardiac output values, which in the very alert awake and rapid-eye-movement sleep states significantly exceed values in the other states.

Animals↗