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Biomedical subjects

Y Dananchet

Publications and source records attributed to Y Dananchet.

4 recordsLinked to original sources

[A family with exercise-induced paroxysmal dystonia and childhood absence epilepsy].

INTRODUCTION: The boundary between epilepsy and paroxysmal dyskinesia appears to be less easy to delineate than previously believed. Reports of families showing both phenomena suggest a shared pathophysiology. PATIENTS AND METHOD: A new family with autosomal dominant exercise-induced paroxysmal dystonia is reported. RESULTS: Two family members also had childhood absence epilepsy, and one of them suffered from acute transient hemiplegia at age 10. CONCLUSION: The association of epilepsy and paroxysmal dyskinesia has been rarely reported in the literature, and several loci have been identified. Absence epilepsy and exercise-induced paroxysmal dystonia appear to be very uncommon, although some reports mentioned the association in sporadic and familial cases. The involvement of ion channel genes in several transient neurological disorders supports the hypothesis of a common pathophysiological process underlying both the childhood absence seizure and the later paroxysmal dystonia.

Adult↗

[Parsonage-Turner syndrome and giant-cell arteritis].

Parsonage-Turner syndrome is an idiopathic brachial neuropathy affecting the 5(th) and the 6(th) roots. Giant-cells arteritis rarely affects the brachial plexus. In such cases, it can mimic Parsonage-Turner syndrome. We report a case focusing on clinical signs suggesting giant-cell arteritis.

Aged↗

[Neurologic diagnosis and therapy of headaches].

Headaches are a very common complaint for general practitioners and neurologists. When a regional cause has been excluded, the neurologist will class headaches according to the criteria of the International Headache Society. An estimate of the 1-year prevalence of migraine in adults is about 10-15%. First line treatment of migraine attacks consists in aspirin (1 g) with or without metoclopramide or nonsteroidal antiinflammatory drugs. Second line treatment consists in vasoconstrictors, ergotamine or triptans. Beta-blockers are used for first line prophylactic treatment of migraine. Tension-type headache is by far the most common form of headache with a prevalence ranging from 30% to 80% and is more prevalent in women than in men. Nonsteroidal antiinflammatory drugs and muscle relaxants are used for tension-type headache. The prevalence of cluster headache is about 0.1%. Acute treatment consists in inhalation of 100% oxygen at 7 liters/min using a facial mask for 15 minutes or subcutaneous sumatriptan (6 mg), at most twice daily. Chronic paroxysmal hemicrania is a rare type of cluster headache with an absolute effectiveness of indomethacin. Trigeminal neuralgia is rare. However, it is probably the most intense facial pain. Pharmacological treatment is based on carbamazepin. Surgical treatment may be proposed secondarily. In conclusion, the right diagnosis leads to the right treatment. Thus, daily chronic headaches due to drug overuse can be avoided.

Headache↗