Biomedical subjects

Y Depauw

Publications and source records attributed to Y Depauw.

8 recordsLinked to original sources

PubMed1991

[Cognitive evoked potentials in the diagnosis of senile dementia and dementia of Parkinson's disease: significance of multivariate analysis].

P300 latency is often delayed in dementia but some authors have questioned its value in clinical practice, because of the relatively low specificity and sensibility of the method. Numerous parameters (latency, duration, amplitude and surface) of N100, N200 and P300 waves were therefore studied in patients with senile dementia, subjects suffering from Parkinson's disease with dementia, and non-demented elderly patients. Using discriminant analysis, more than 90% of the patients were correctly classified. This method could thus be contributory in diagnosing dementia in clinical practice.

Cognition↗

PubMed1988

Growth hormone response to clonidine in panic disorder patients.

The growth hormone (GH) response to clonidine administration (2 micrograms/kg) was compared in three groups of subjects: seven panic disorder patients, seven depressed patients matched for age and sex, and seven normal controls. As previously reported, patients with affective disorders show a blunted GH response to clonidine. Only one panic disorder patient had a blunted GH response to clonidine, and this patient had recently received a tricyclic antidepressant.

Adolescent↗

PubMed1988

[Contingent negative variation and regional cerebral blood flow in senile dementia and cerebral aging].

Relationships between contingent negative variation (CNV) amplitude, regional cerebral blood flow (CBF), mini mental status examination score (MMSE) and reaction time (RT) have been studied in young subjects, non-demented old subjects and patients with primary degenerative senile dementia. Significant correlations have been found between CNV amplitude and global CBF, MMSE score and reaction time. Factorial analysis has shown 3 factors weighted respectively by MMSE and CNV, antero-posterior ratio fort left hemispheric CBF and age, and antero-posterior ratio for right hemispheric CBF and reaction time. Discriminant analysis has shown 2 discriminant functions differentiating young from old subjects with 90% accuracy and demented from non-demented patients with 75% accuracy.

Adult↗

PubMed1983

[The Risk-Rescue Scale and evaluation of suicidal persons].

The R-S scale evaluates the lethality of suicidal acting-out behavior. We applied it, in the first phase, to 97 patients. The differences between our results and those of Weisman and Worden bring us to frame two hypotheses: either the differences are due to the specific nature of each population, or the differences are due to the observers. In the second phase, we apply the R-S scale to 170 patients. Across the three groups studied (Weisman and Worden's, our first phase, our second phase), we note that in the first phase there are differences linked to the observers, but that the specific nature of the respective populations also contribute to the differences. This is all the more obvious when we consider the number of suicide attempt repeaters within each group.

Adolescent↗

PubMed1983

[Detection of suicide attempts likely to be repeated within a year].

According to the World Health Organization, 20-30% of suicide attempters make a new attempt within 12 months. Buglass and Horton have proposed a 6-point clinical scale meant to predict the risk of repetition within a year. The authors used this instrument on 183 suicide attempters. Based on the new attempts actually observed, they discuss the validity and the specificity of this instrument.

Adult↗

PubMedDate not supplied

Age and gender effects on the diagnostic power of the DST.

Among 365 major and 158 minor depressive inpatients, the dexamethasone suppression test (DST) yielded an overall diagnostic sensitivity of 50%, a specificity of 85%, and a confidence level of 88%. Age was significantly correlated with the post-dexamethasone cortisol levels in the whole sample (r = 0.11; P less than 0.01); however, this low relationship disappeared when all subgroups defined by gender or diagnostic were considered. Gender did not appear to influence DST results; however, among the patients between 30 and 39 years, the diagnostic performance of the DST was significantly lower among female as compared to male patients, suggesting possible interferences with endocrine variables.

Adult↗

PubMedDate not supplied

[The value of cognitive evoked potentials in the diagnosis of senile dementia and dementia of Parkinson disease].

P300 latency is often delayed in dementia but some authors have questioned its interest in clinical practice, because of the relatively low specificity and sensibility of the method. Therefore, we studied numerous parameters (latency, duration, amplitude and surface) of N100, N200 and P300 waves in patients with senile dementia, patients suffering from Parkinson's disease with dementia and non demented elderly patients. Using discriminant analysis, more than 90% of the patients were correctly classified. This method could thus be contributive in clinical practice.

Aged↗

PubMedDate not supplied

[Dexamethasone suppression test repeated after a suicide attempt].

The authors performed 3 consecutive DSTs in 54 non-endogenous depressives admitted after a suicide attempt. The DST results are not correlated with the lethality of the suicide attempt. Stress and numerous drug interactions are most probably responsible for the high proportion of DST nonsuppressors among our patients.

Adolescent↗