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Biomedical subjects

Y Erdem

Publications and source records attributed to Y Erdem.

At least 37 records · Page 2Linked to original sources
PubMed1998

Compliance in hemodialysis patients: unanticipated monitoring of biochemical indices.

Compliance with the prescribed medical regimen is a critical factor for the continued well-being of hemodialysis patients. As compliance is a multifactorial problem, numerous approaches have been utilized to quantify the compliance of hemodialysis patients. In the present study, we have attempted to examine whether unanticipated control of biochemical indices might predict the compliance status of hemodialysis patients. We compared unanticipated mid-month values of blood urea nitrogen (BUN), serum potassium (K) and phosphate (PO4) values of 54 maintenance hemodialysis patients with the scheduled, regular first-week measurements during a 6-month study period. The interdialytic weight gain (IWG) levels of the corresponding weeks were also compared. Mid-month analysis revealed a significant deviation in the compliance status of the study population as BUN, serum K and IWGs were concerned (p < 0.05). The mid-month serum PO4 levels were also higher but the difference was not significant (p < 0.05). In conclusion, the differences observed in biochemical indices upon change of test request timing were distinctive. It suggests that unanticipated control of biochemical indices might contribute to the actual assessment of compliance in hemodialysis patients.

Adult↗
PubMed1998

Rapidly progressive glomerulonephritis associated with hepatitis C virus infection.

Glomerular disease often accompanies a wide variety of liver diseases, including acute or chronic hepatitis. A striking association between hepatitis B virus and glomerulonephritis particularly membranous glomerulonephritis has been reported by various authors. It is not surprising, therefore, that hepatitis C virus (HCV) infection has been recently associated with the development of various types of glomerulonephritis. The principal type of glomerulonephritis associated with HCV infection is either cryoglobulinemic or non-cryoglobulinemic membranoproliferative glomerulonephritis. However, other types of glomerular lesions were seen in the clinical course of HCV infection. We report a rare case of a 20-year-old woman who developed rapidly progressive glomerulonephritis (RPGN) during the course of the active HCV infection. Whether this case represents a true association or a coincidental association is not known.

Adult↗
PubMed1998

Environmentally-induced malignant pleural mesothelioma and HLA distribution in Turkey.

SETTING: A large university hospital in Ankara, Turkey. OBJECTIVE: To investigate the potential links, if any, between the occurrence of malignant pleural mesothelioma (MPM) and the presence and distribution of human leukocyte antigens (HLA) in patients environmentally exposed to asbestos and erionite in rural Anatolia, Turkey. DESIGN: A case-control study design was used to compare the relative frequency and distribution of HLA among 31 MPM patients originating from the fibrous zeolite (erionite) and asbestos villages in central Anatolia, and two sets of controls. The cases represented all of the MPM cases diagnosed between 1995 and 1997 in our clinic at the Hacettepe University Hospital. One control group of 119 healthy individuals was drawn from Tuzköy, which has the largest population of three erionite villages, a very high prevalence of mesothelioma due to environmental exposure to erionite, and accounted for 16 of the MPM cases in the study. A second control group composed of 118 renal transplant donors was formed for external comparison. RESULTS: A significant relation was found with the HLA-B41 antigen in 19.4% of the patients compared to 0.8% of the Tuzköy inhabitants (odds ratio [OR] 28.3; 95% confidence interval [CI] 3.1-652.5) and 1.7% of the referent renal donor population (OR 13.9; 95% CI 2.3-106.7). The frequency of the HLA-B58 and -DR16 antigens was also observed to be significantly higher in patients with MPM compared to the two control groups. The odds ratios of MPM in those with HLA-B58 were 8.6 (95% CI 1.2-72.4) and 8.5 (95% CI 1.2-71.8), respectively, compared to those of the Tuzköy inhabitants and renal donors. CONCLUSION: The predictive role of the HLA antigens -B41, -B58 and -DR16 for MPM needs to be further investigated. This will help in screening the population at risk, and facilitate preventive measures such as family counselling and gene therapy.

Adult↗
PubMed1996

Effect of extracorporeal shock wave lithotripsy on glomerular and tubular functions.

To evaluate the early and late effects of extracorporeal shock wave lithotripsy on renal function, we prospectively designed a controlled study using a Direx lithotriptor. Twenty-five patients with renal stones and 16 healthy volunteers as the control group were included in the study. Blood and urine samples were collected before and after 24 hours, seven days and 8 months in the patient group. White blood cell count, serum levels of haemoglobin, urea, creatinine, SGOT, SGPT, AP, and LDH were determined. 24-hour urine specimens were collected to be tested for volume, excretion of creatinine, albumin, N-acetyl-beta-glucosaminidase, gamma-glutamyltransferase and beta-2-microglobulin. There were statistically significant increments in the secretion of urinary enzymes and albumin in the early period after ESWL, no longer lasting 8 months after the procedure. At 8 months one patient was hypertensive as judged by the diastolic pressure above 95 mm Hg. The results of this study showed that, although there was a transient glomerular and tubular damage after extracorporeal shock wave lithotripsy, the procedure seems safe and causes no permanent deterioration in renal function.

Adult↗
PubMed1996

Severe renal vasoconstriction and anuria after intravenous urography in a patient with renal impairment.

Acute renal failure caused by radiocontrast agents remains a severe problem, particularly in patients with risk factors. There is debate concerning the pathophysiology of contrast media-induced acute renal failure, including, but not limited to, renal ischemia or tubular damage. Vascular ischemia is considered a major contributor because consistent changes in renal hemodynamics have been recorded experimentally. We describe a patient who has a typical course of contrast-associated renal failure manifested by severe renal vasoconstriction and backflow of the contrast agent during renal angiography performed after 6 days of an intravenous urography. Such degree of renal vasoconstriction is noteworthy in that this particular case might serve as a model in delineation of the pathogenetic mechanisms of acute renal failure after contrast media administration.

Acute Kidney Injury↗
PubMed1996

Local fibrinolysis in native arteriovenous fistulas of haemodialysis patients.

This study was designed to evaluate local alterations of the fibrinolytic process in patent-functional native arteriovenous fistulas of patients on maintenance haemodialysis. For this aim, the concentrations of the main components of the fibrinolytic system were determined in plasma samples taken simultaneously from arteriovenous fistulas and contralateral upper extremity concurrent large veins of haemodialysis patients. Twelve patients (6 women and 6 men, age 36 +/- 8 years) with end-stage renal disease on maintenance haemodialysis and 15 non-smoker healthy volunteers (8 women and 7 men, age 31 +/- 10 years) with normal renal function were included in the study. The fibrinolytic parameters, except alpha 2-antiplasmin, were found to be elevated in arteriovenous fistulas of haemodialysis patients as compared with opposite upper extremity large veins of the same patients (p < 0.005). Increments in fibrinolytic parameters including tissue plasminogen activator antigen, urokinase-type plasminogen activator antigen and activity, and plasminogen activity together with lower alpha 2-antiplasmin levels favor activation of fibrinolysis, except for higher alpha 2-macroglobulin concentrations, in arteriovenous fistula. The study suggests that the fibrinolytic process is locally activated in arteriovenous fistulas of haemodialysis patients.

Adult↗