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Biomedical subjects

Y F Leung

Publications and source records attributed to Y F Leung.

At least 19 recordsLinked to original sources
PubMed2003

Unimuscular neuromuscular insult of the leg in partial anterior compartment syndrome in a patient with combined fractures.

A complicated case of ipsilateral fractures of the left femur and tibia after a road traffic accident is reported. The patient presented with numbness of the first web of his left foot and contracture of the extensor hallucis longus muscle, with fixed length deformity after intramedullary nailing of the femur and tibia. The extensor digitorum longus and tibialis anterior muscles were spared. Tinel's sign could be elicited at the mid-portion of the anterior compartment of the injured leg. This indicated that the distal half of the anterior tibial nerve (deep peroneal nerve), together with the extensor hallucis muscle of the anterior compartment of the leg, had been damaged. The subsequent management of this patient is described.

Accidents, Traffic↗
PubMed2001

The miracle of microarray data analysis.

A report on the tenth Annual Bioinformatics and Genome Research meeting of the Cambridge Healthtech Institute's Beyond Genome 2001 series, San Francisco, USA, 17-19 June 2001.

Humans↗
PubMed2001

All aboard the chip!

The Cambridge Healthtech Institute's Microarrays and Microchips conference was held in Tokyo, Japan, 4-5 June 2001.

Biotechnology↗
PubMed2001

Incidence of deep vein thrombosis after colorectal surgery in a Chinese population.

INTRODUCTION: Contemporary studies indicate that the incidence of deep vein thrombosis (DVT) is increasing in the Asian population. The present study aims to evaluate the incidence of postoperative DVT in Chinese patients undergoing surgery for colorectal malignancies. METHODS: Fifty-one consecutive patients with carcinoma of the rectum or sigmoid colon scheduled for resection were included in the study. None of the study subjects were given any form of DVT prophylaxis. Serial duplex ultrasound of both lower limbs were examined in the preoperative and postoperative periods. RESULTS: Three patients were excluded from the study because of the presence of DVT noted preoperatively. A total of 20/48 (41.7%) patients developed asymptomatic calf vein thrombosis. One out of 20 patients required anticoagulation because of thrombus propagation. None of the subjects showed signs or symptoms of DVT or pulmonary embolism. A total of 7/20 thrombi resolved completely at 4 weeks after operation. Only old age and smoking were identified as being associated with a higher incidence of DVT. Disseminated disease, type of operation, duration of operation and postoperative complications did not appear to be risk factors for DVT. CONCLUSION: A high incidence of asymptomatic calf vein thrombosis occurred after colorectal surgery for malignancies in Chinese. The majority did not progress even without anticoagulation.

Age Factors↗
PubMed2001

High-throughput conformation-sensitive gel electrophoresis for discovery of SNPs.

High-throughput screening for single nucleotide polymorphisms (SNPs) or mutations can be achieved by inexpensive technologies. We modified the original protocols of conformation-sensitive gel electrophoresis (CSGE) to increase throughput several fold to 1.3 samples/min, which is about five times faster than denaturing high-performance liquid chromatography (DHPLC). The modifications include decreasing the gel thickness, increasing the number of lanes to 96, and increasing the number of samples per lane to seven. This high-throughput CSGE method is fast, robust, and as simple as the original protocols. Together with a two-stage strategy for screening homozygotes and the replacement of ethidium bromide with SYBR Gold DNA dye staining, this protocol is a reliable and cost-effective alternative for laboratories that require high-throughput screening.

Heterozygote↗
PubMed2000

Depression in institutionalised older people with impaired vision.

OBJECTIVES: For depression in institutionalised elders with visual impairment, there is a lack of information in the literature. A panel study was performed: (1) to determine the prevalence of depressive symptoms, and (2) to investigate the risk factors of depression. METHOD: Residents of a nursing home for the aged blind were recruited. Measurements included: Geriatric Depression Scale (GDS), Snellen Eye Chart, age, duration of institutionalisation, duration of impaired vision, and functional ability. RESULTS AND CONCLUSIONS: The proportion of participants who scored GDS> or =6/15 was 45.2%. The rate of depression among visually impaired nursing home residents is higher compared to other populations reported. The depressed participants had significantly shorter duration of institutionalisation (3.4 years vs 7.1 years, rank-sum, p=0.007) and lower functional ability (Barthel Index 60.7/100 vs 85.6/100, rank-sum, p=0.002) as compared to the non-depressed. No significant difference was found in age and length of impaired vision. A logistic regression model predicting depressive symptoms found that the duration of institutionalisation (odds ratio 0.75; 95% confidence interval 0.59-0.94), and functional ability (odds ratio 0.96; 95% confidence interval 0.92-0.99), were independently and inversely associated with depressive mood after controlling for age and duration of blindness. The effects of blindness and living in a long-term care institution were identified. Recommendations on screening and management of depression were provided.

Activities of Daily Living↗
PubMed2000

Tuberculous osteomyelitis of the scapula.

Tuberculous osteomyelitis is an uncommon disease entity. We report two cases of tuberculous infection of the scapula, one involving the acromion and one involving the body of the scapula. Tuberculosis is still an important differential diagnosis in unusual or chronic bone conditions.

Adult↗
PubMed2000

Absence of trabecular meshwork-inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients.

We investigated the coding exon and promoter sequence in the trabecular meshwork-inducible stretch response (TISR)/oculomedin gene for mutations in Chinese primary open angle glaucoma (POAG) subjects. The entire TISR/oculomedin coding sequence, together with 138 bp of promoter sequence 5' to the start codon and 170 bp of the 3' untranslated region in 110 Chinese POAG patients and 108 unrelated control subjects without glaucoma, aged 50 years or above, were screened for alterations by DNA sequencing. One heterozygous sequence alteration, K28E, was identified in one control subject, and two homozygous sequence alterations, K28K and 135+36delC, were universally found in every sample. As a result, no common TISR/ oculomedin coding sequence nor any proximal promoter mutation that causes POAG was found. The effect of TISR/ oculomedin in glaucoma has yet to be established.

Adolescent↗
PubMed2000

Comparison of tamoxifen with danazol in the management of idiopathic gynecomastia.

Idiopathic gynecomastia, unilateral or bilateral, is a common physical finding in normal men. Successful treatment using tamoxifen (antiestrogen) and danazol (antiandrogen) has recently been reported. We compared the efficacy of tamoxifen and danazol in the treatment of idiopathic gynecomastia. We reviewed the clinical records of patients with idiopathic gynecomastia presenting to the Department of Surgery, University of Hong Kong, between August 1990 and September 1995. Medical treatment with either tamoxifen (20 mg/d) or danazol (400 mg/d) was offered and continued until a static response was achieved. The treatment response was compared. Sixty-eight patients with idiopathic gynecomastia were seen in the Breast Clinic. The median age was 39.5 years (range, 13-82), with a median duration of symptoms of 3 months (range, 1-90). The median size was 3 cm (range, 1-7). Twenty-three patients were treated with tamoxifen and 20 with danazol. Complete resolution of the gynecomastia was recorded in 18 patients (78.2%) treated with tamoxifen, whereas only 8 patients (40%) in the danazol group had complete resolution. Five patients, all from the tamoxifen group, developed recurrence of breast mass. In conclusion, hormonal manipulation is effective in the treatment of patients with idiopathic gynecomastia. Although the effect is more marked for tamoxifen compared with danazol, the relapse rate is higher for tamoxifen. Further prospective randomized studies would be useful in defining the role of these drugs in the management of patients with idiopathic gynecomastia.

Adolescent↗