Biomedical subjects
Publications and source records attributed to Y Fukagawa.
A streptomycete strain, P3409, which produced new basic macrolide antibiotics, deltamycins A1, A2 and A3 and carbomycin A (deltamycin A4) was considered to be a new subspecies for which the name Streptomyces halstedii subsp. deltae was proposed. Deltamycins A1, A2, A3 and A4 which were active against Gram-positive bacteria were produced in organic complex media.
The new macrolide antibiotics were isolated by silica gel chromatography. They showed a UV absorption maximum at 240 nm. Deltamycins A1, A2 and A3 were demonstrated to be new macrolide antibiotics on the basis of their physicochemical properties whereas deltamycin A4 was identified as carbomycin A.
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