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Y Gille

Publications and source records attributed to Y Gille.

33 records · Page 2Linked to original sources
PubMed1985

Pefloxacin: evolution of in vitro activity during 18 months of use in an intensive care unit.

The MIC of pefloxacin against all the strains (3122) isolated in an intensive care unit during 18 months was studied. The MIC of pefloxacin was estimated by standard agar diffusion method in Mueller-Hinton agar. All the strains with a MIC lower than 2 mg/l were considered as sensitive, between 2 and 4 mg/l as "intermediary" and over 4 mg/l as resistant. Geometrical means of MICs were calculated for each month and for different species. The study continued for 18 months from the introduction of the drug which was in widespread and constant use as a first-choice antibiotic. No significant increase was detected in the incidence of resistant strains during the study; on the other hand, small, limited clusters of resistant strains were observed during minor nosocomial epidemics. The general features of quinolone activity, the spectrum of this new quinolone and the slow evolution of the bacterial population are discussed.

Bacteria, Aerobic↗
PubMed1983

[Variations in vitro of the efficacy of quinolones as a function of pH].

pH induced changes of bacteriostatic activity of nalidixic, pipemidic and oxolinic acids have been studied in vitro by the determination of minimal inhibitory concentrations (MIC), on 9 different species and 172 strains, at pH 5, 6, 7 and 8 and with increasing antibiotic concentrations. The bacteriostatic activity of nalidixic acid is higher at acid pH and conversely the bacteriostatic effects of pipemidic and oxolinic acids are enhanced at basic pH. The relationship between pH and MIC seems to be more dependent on the type of the micro-organism than on the antibiotic which is tested. A study of the bactericidal effect of quinolones on E. Coli and Pr. Morganii has shown a sharp increase of bactericidal activity at basic pH. These results support the idea that alkalinization is a useful addition to the treatment of severe urinary infections by quinolones.

Anti-Infective Agents, Urinary↗
PubMed1982

Serological grouping of streptococci: a collective evaluation in six laboratories of three rapid methods.

Three serological methods for streptococci grouping: latex agglutination after pronase extraction (LAP), latex agglutination after nitrous acid extraction (LAN) and counterimmunoelectrophoresis after nitrous acid extraction (CIEN) were evaluated in six laboratories with 310 strains of streptococci. To reduce the possible influence of a particular laboratory, each serological procedure was performed in two different laboratories with identical protocols and strains. Between the three procedures, a total agreement of 81.3% with six identical results was obtained. Since only one discordant result was obtained in 12.2% (CIEN 4.8%-LAN 5.8%-LAP 1.6%) and two discordant results with two different serological methods in 2.6%, it could be concluded that agreement between the three procedures was 96%. For B (99 strains tested) and D(100 strains tested) groups, total agreements of respectively 95% and 92% were achieved. In conclusion, LAP, LAN, and CIEN gave equivalent results for streptococci grouping, but LAN was the most simple needing no heating, centrifugation, or electrophoresis equipment and lacking cross-reactivity of group C antibody.

Counterimmunoelectrophoresis↗
PubMedDate not supplied

[Urinary infection in urology. A rapid technique for confirmation of the diagnosis and the orientation of medical treatment (author's transl)].

A rapid technique for confirmation of the diagnosis and the orientation of medical treatment of urinary infection. Performance of direct antibiotic sensitivities on urine is a rapid (14 to 18 hours) procedure for determining the presence of organisms in the urine and seeking the antibiotic most active against them. In order to assess the value of the procedure, it was compared with classical bacteriological techniques. The correlation was found to be satisfactory. This procedure of direct sensitivity studies on urine is not in to way in competition with classical bacteriological techniques but is of great value in rapidly confirming the diagnosis of urinary infection and in the orientation of therapy. It eliminates a number of the justifications of blind treatment.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Susceptibility of anaerobic bacteria to cefoxitin (author's transl)].

Nine strains of Clostridium perfringens type A and 10 strains of Bacteroïdes fragilis s. spec. fragilis, recently isolated from blood culture, were tested for their cefoxitin susceptibility. The MIC for Clostridium perfringens ranged from 0,6 to 5 mg/l and 1,2 to 10 mg/l for Bacteroïdes fragilis. In most cases, the MBC were identical with the MIC for Clostridium perfringens, but for Bact. frag. there was a difference of 2 dilutions in their MBC. Cefoxitin activity was not modified by a variation in inoculum density.

Bacteroides fragilis↗