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Biomedical subjects

Y H Bao

Publications and source records attributed to Y H Bao.

7 recordsLinked to original sources
PubMed1997

Classification and therapeutic modalities of spinal vascular malformations in 80 patients.

OBJECTIVE: To set up a more detailed classification system for spinal vascular malformations and to discuss the relationship between the classification and therapeutic alternatives. METHODS: Case series from the tertiary care center were studied. Spinal vascular malformations in 80 patients were reviewed and classified into intramedullary arteriovenous malformations (AVMs) (juvenile and glomus AVMs), intradural arteriovenous fistulas (AVFs) (Type I-III), dural AVFs, paravertebral AVMs, and Cobb's syndrome. Therapeutic alternatives to each type of spinal vascular malformations, including surgery, endovascular embolization, and a combination of both, as well as the short-term outcomes, were analyzed. RESULTS: Of the 80 patients, 38 (47.5%) had intramedullary AVMs (23 juvenile and 15 glomus AVMs), 27 (33.8%) had intradural AVFs (6 Type I, 14 Type II, and 7 Type III), 8 (10%) had dural AVFs, and 7 (8.8%) had other malformations. Most of the juvenile AVMs and the Types II and III AVFs were treated by endovascular embolization. Other lesions were treated by surgery or preoperative embolization plus surgery. Among the 76 patients whom we treated, early clinical improvement was achieved in 66 (86.8%). Six (7.9%) remained stable, and four (5.3%) became worse. CONCLUSION: Our classification system offers only limited guidance for the treatment of spinal vascular malformations. Successful treatment in each individual spinal vascular malformation requires correct understanding of the lesion's anatomic location and its angioarchitecture, as well as the limitations of both surgery and endovascular embolization.

Angiography↗
PubMed1994

Myelopathy and multiple aneurysms associated with aortic arch interruption: case report.

We report a very unusual association of multiple aneurysms in the cranial cavity and the spinal canal, anterior spinal artery syndrome, syringomyelia, and aortic arch interruption between the origins of the left common carotid artery and the left subclavian artery. A 14-year-old boy with a history of 2 years of flaccid paraplegia and rectal and urinary incontinence after two spontaneous subarachnoid hemorrhages was encountered in August 1993. Through extensive physical and neuroradiological investigation, an association was found. Because almost all infants with aortic arch interruption die within the first month of life, this older patient gave us an opportunity to study the collateral network and the effect of hemodynamic abnormality on the central nervous system. For treatment, we believe that surgery should be directed to the hemodynamic abnormality of the aortic arch interruption. After bypass surgery from the ascending aorta to the abdominal aorta with an artificial vessel graft, the patient had some neurological improvement, as demonstrated by the sensation level lowering from T7 to L1.

Adolescent↗
PubMed1993

Parasellar epidural hydatid cysts.

We report two rare cases of parasellar epidural hydatid cysts. Among the 64 patients with intracranial hydatid cysts we have treated in the past 20 years, only these two cases were located epidurally. Because the location and the computed tomographic characteristics were so different from the other cysts, the preoperative diagnosis was difficult to make. We were unable to remove the cysts without rupturing them because they were tightly surrounded. Both patients underwent surgery twice because of a recurrence. The treatment of this kind of case requires further discussion.

Adult↗
PubMed1992

[High dose chemotherapy with autologous bone marrow rescue for small cell lung cancer].

The efficacy of high dose chemotherapy with autologous bone marrow rescue (ABMR) was given to 10 patients with small cell lung cancer (SCLC). Four patients received high dose methotrexate plus ABMR followed by chest irradiation. Six patients giving complete response after induction chemotherapy were given intensive chemotherapy plus ABMR only. The over-all survival of these 10 patients was 30.5 months with a range of 6-96 months. Five of them are surviving as of this writing, 3 survived for more than two years and 2 for more than 5 years. Toxic reactions were not severe. Systemic metastasis was the Leading cause of treatment failure. ABMR was effective and safe. When combined with radiotherapy ABMR could be expected to improve the result of intensive chemotherapy for limited SCLC.

Adult↗
PubMed1991

Cisplatin as a radiosensitizer in clinical practice: a pilot study.

Fifty-four patients with inoperable cancers were treated with a combination of cisplatin and radiotherapy from May 1984 to February 1989. Cisplatin was administered at a dose of 40 mg/week, for a total dose of 160-320 mg, during radiation therapy. In 4 cases with brain metastases, the cisplatin dose was 40 mg/m2. Cisplatin concentration in blood was measured using the flameless atomic absorption spectrophotometric method. Radiation therapy was delivered by a 6 MV X-ray or a cobalt-60 unit up to a total dose of 50-70 Gy. Among the 54 patients, 89% (48) responded to the treatment regimen; complete responses (CR) and partial responses (PR) were 56% and 33%, respectively. Six patients were stable in their disease. Among the 30 patients who had CR's, the 1-year survival rate was 88% (21/24). Two patients (7%) had local relapse. However, among PRs, the 1-year survival rate was 33% (4/12) and local failure (61%) (11/18). Objective tumor response was observed in 4 cases with brain metastasis, 2 of the 4 patients were alive for more than 6 months. Toxic effects were moderate and consisted of emesis and myelosuppression. Grade III bone marrow suppression amounted to 11%, and the interval of recovery was relatively long compared with that reported in the literature. Further prospective controlled studies are recommended.

Adult↗
PubMed1983

Electron microscopic studies on the chromatin of blastoderm nuclei and yolk granules beneath blastoderm of fertilized and unincubated chicken eggs.

Chromatin prepared both from the yolk granules beneath the blastoderm and from the nuclei of the blastoderm cells of fertilized and unincubated chicken eggs was examined under electron microscope and its structure was compared. The results indicate that the above two kinds of chromatin fibers seem to have no apparent difference in structural relation and diameter. The electron microscopic appearances of the basic structures of both kinds of chromatin are all "beads-on-a-string"-shaped filaments. After the digestion of chromatin from both raw materials with DNase I, the connecting strings of chromatin fibers were cut off, only the scattered beads could be observed under electron microscope. The diameter of the scattered beads is equal to that of the beads on the chromatin fibers, and most of them are 150 A in diameter.

Animals↗