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Biomedical subjects

Y Hamai

Publications and source records attributed to Y Hamai.

16 recordsLinked to original sources
PubMed1979

Combined treatment with by-pass operation, irradiation and immunochemotherapy for advanced thoracic esophageal cancer.

Based on the experimental results that operative stress of thoracotomy or laparothoracotomy has enhanced tumor growth remarkably in rats compared with laparotomy, a new combined treatment with by-pass operation, irradiation and immunochemotherapy was investigated in 39 advanced thoracic esophageal cancer patients. At by-pass operation, abdominal esophagus was divided and its proximal stump was closed immediately. Cervical esophagus was then divided and its distal stump was pulled out to the right supraclavicular region to make outer fistula. Thus, anticancer drug was poured into the esophagus through outer fistula very easily just before irradiation and then irradiation was performed under the condition that the lesion was immersed in the drugs. As anticancer agent, Mitomycin-C, 5-Fluorouracil or Bleomycin was given alternately. Lately, the combination of 5-Fluorouracil and Vitamin A was preferably used. The changes of immunological parameters and the survival after the onset of treatment was reported.

Adult↗
PubMed1978

On the findings of stroke-prone SHR.

The fundus of 82 SHRSP were observed and all of them showed the narrowing caliber irregularity of retinal arterioles and optic disc edema. Moreover, tortuosity of retinal arterioles was characteristic.

Animals↗
PubMed1978

Fluorescein fundus angiography of stroke-prone SHR.

The fluorescein fundus angiography was performed on SHRSP, SHR, and NR. The following results were obtained. 1. No expravasation of fluorescein from retinal vessels of SHR and NR was observed at any phase of circulation. 2. The extravasation of fluorescein from retinal arterioles and peripapillary capillary of SHRSP of post-hypertensive stage was seen at arterial phase of circulation. These extravasation of fluorescein coincided with the initial stage of stroke incidence.

Animals↗
PubMed1978

Enhancing effect of thoracotomy on tumor growth in rats.

To indicate the influence of operative stress on tumor growth, thoracotomy and/or laparotomy were performed 48 hr after intraperitoneal or intravenous inoculation of Sato lung cancer into Donryu rats. Survival period, number of metastatic nodules on the surface of the lungs, and the percentage-area of metastases in the frontal section through pulmonary hilus were examined. By thoracotomy and laparothoracotomy the survival period of the tumor-inoculated rats was reduced significantly compared with that of the control but difference between these two test groups was not significant. Also there was no significant difference between the laparotomy group and the control. The results obtained in the number and percentage-area of metastatic nodules were quite similar to that observed in the survival period. Correlation between the number and the percentage-area of metastatic nodules was highly significant. The meaning of the stress of thoracotomy in cancer treatment is discussed.

Animals↗
PubMed1977

Enhancing effect of thoracotomy and/or laparotomy on the growth of ascitic tumor in rats.

To evaluate the effect of operative stress on a tumor growth, thoracotomy and/or laparotomy were performed 48 hours after the intraperitoneal inoculation of Sato lung cancer cells in Donryu rats. The survival time and the spread of the tumor were examined. Thoracotomy and laparothoracotomy reduced significantly the survival time of the inoculated rats as compared with the control but no significant difference was observed between the two test groups subjected to operative stress. No difference was observed in the spread of the tumor between the test groups and the control. These results indicated that the operative stress increased only the number of metastatic foci and did not change the characteristics of the tumor cells.

Animals↗
PubMed1977

Enhancing effect of thoracotomy and/or laparotomy on the development of the lung metastases in rats after intravenous inoculation of tumor cells.

To evaluate the effect of operative stress on the tumor growth, thoracotomy and/or laparotomy were performed 48 hours after the inoculation of Sato lung cancer cells in Donryu rats. The survival time, the number of metastatic foci on the surface of the lung and the per cent-area of metastatic foci in the frontal section through the pulmonary hilus were observed. Thoracotomy and laparothoracotomy reduced significantly the survival time as compared with the control but no significant difference was found between the two test groups subjected to operative stress. The number of percent-area of metastatic foci found were inversely related to the length of the survival time.

Animals↗
PubMed1975

A new procedure for transabdominal resection of esophagocardial cancer and cervical anastomosis obviating thoracotomy.

A new operative technique for esophagocardial cancer was reported with resection and re-establishment of alimentary continuity at cervical esophagus which obviates thoracotomy but still retains adequate removal of the lesion. Ten cases of esophagocardial cancer thus treated were presented and the clinical data were analyed. The distance between esophageal stump and esophagocardial junction measured on the resected specimen ranged from 3.0 to 6.7 cm with an average of 5.1 cm. No remaining tumor cells were detected microscopically on the oral cut margin of the specimen in all cases. To compensate for the inadequated lymph node dissection intensive postoperative adjuvant irradiation and/or chemotherapy was advocated.

Abdomen↗
PubMed1975

Early cytologic changes of Fraser cataract. An electron microscopic study.

The cataractous lens of the Fraser strain mouse was studied electron microscopically in its early developmental stage. Cytologic abnormalities were found in the cells of the invaginating ectodermal cell of the early optic cup. Morphogenetically degenerating cells were more numerous in this stage. In general, cells of the posterior layer of the developing lens elongated normally. However, they contained great numbers of dilated rough endoplasmic reticulum, vacuoles, and mitochondria, but less amounts of crystalline substance and polysomes. During the further differentiating stage (thirteenth and fourteenth fetal day), apical portions of these cells began to swell and the lens became opaque. The swollen lens cells degenerated after this stage.

Animals↗