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Biomedical subjects

Y Hanabusa

Publications and source records attributed to Y Hanabusa.

11 recordsLinked to original sources
PubMed2005

Redo aortic valve replacement with ''porcelain'' aorta in an aortitis patient. A case report.

We report a successful reoperation of aortic valve replacement with the severely calcified, ''porcelain'' aorta due to Takayasu's disease. The patient was a 46-year-old female diagnosed with aortic prosthetic valve failure. Takayasu's aortitis had been noted at 17 years old and the patient underwent aortic valve replacement for aortic regurgitation at age 32. Chest CT scan revealed severe circumferential calcification of the whole thoracic aorta. Echocardiography revealed 100 mmHg of pressure gradient across the aortic prosthetic valve with pannus formation. Replacement of the aortic prosthetic valve was performed using the selective cerebral perfusion method under deep hypothermia. The postoperative course was uneventful without any neurological disorder. Selective cerebral perfusion was a useful method to avoid cross clamping in severely calcified ascending aortic.

Angiography, Digital Subtraction↗
PubMed1996

[The shock patients with the cardiac tamponade resulting from acute type A aortic dissection].

Twelve patients with acute type A aortic dissection were admitted at Ohta-Nishinouti Hospital from Jan. 1991 to Mar. 1994. Three of these 12 cases were in shock with cardiac tamponade on arrival at the hospital. Immediate resuscitative management was necessary for these patients, but pericardiocentasis was fruitless in the first case and emergent thoracotomy had led to the aortic rupture. While the second case was the thrombosed type aortic dissection and successfully performed pericardiocentasis, CT findings showed recanalization of the pseudolumen after a day, then we performed the urgent operation. By means of these experiences, the third case was operated quickly in spite of the thrombosed type aortic dissection, and had good result. We concluded that immediate surgical intervention should be taken to the shock patients with cardiac tamponade resulted from acute type A aortic dissection.

Acute Disease↗
PubMed1995

[Post operative mediastinitis: the experience of two cases after graft replacement of the ascending aorta].

A mediastinitis after a graft replacement of the ascending aorta is serious complication and sometimes could be lethal. We have experienced two cases of such a condition, recently. In both cases, the debridement of the mediastinum and omental transposition were performed. Case 1 had a recurrent mediastinitis due to residual dead space infection, but was cured by a percutaneous drainage and a continuous irrigation. In case 2, the omentum was carefully positioned to occupy the dead space around the graft, because of the experience of the first case and gave a good result. We believe that omental transposition is an effective treatment for the postoperative mediastinitis.

Adult↗
PubMed1992

Inhibitory effects of endothelin-1 and endothelin-3 on prolactin release: possible involvement of endogenous endothelin isopeptides in the rat anterior pituitary.

Spontaneous prolactin release from the isolated rat anterior pituitary was inhibited by endothelin-1 in a dose-dependent manner (10(-8)-10(-6) M). Endothelin-3 also inhibited spontaneous prolactin release with an almost identical dose-response relationship as endothelin-1. These inhibitory effects were unaffected by application of a dopamine D2-receptor antagonist, YM-09151-2 (10(-7) M). Rat anterior and posterior pituitary glands were abundant in both endothelin-1 and endothelin-3, as compared with other regions of the brain. The present results suggest that endogenous endothelin-1 and endothelin-3 in the anterior and posterior pituitary are involved in the inhibitory regulation of prolactin secretion as autocrine or paracrine factors.

Analysis of Variance↗
PubMed1990

Decrease of prolactin secretion via stimulation of pituitary dopamine D-2 receptors after application of talipexole and SND 919.

The present experiments were performed to investigate the effects of talipexole (B-HT 920) and SND 919 on prolactin release from the anterior pituitary glands of rats both in vivo and in vitro. The basal serum prolactin levels were reduced dose dependently by s.c. administration of talipexole or SND 919 at doses of 5-100 micrograms/kg. Daily treatment with estradiol (35 micrograms/kg for 3 days) increased serum prolactin levels in male rats to levels 4-fold higher than those of non-primed rats. This increase was suppressed by administration of talipexole or SND 919. In vitro, the spontaneous prolactin release into perfusates from isolated anterior pituitary was inhibited by talipexole or SND 919 added at concentrations ranging from 10(-9) to 10(-6) M. This inhibitory effect of SND 919 was blocked by concurrent application of a dopamine D-2 receptor antagonist, YM-09151-2. The spontaneous prolactin release from the anterior pituitary isolated from estradiol-primed rats was 2-fold higher than that from non-primed rats. This increased release was also inhibited by application of either drug. The inhibitory effects of these drugs were greater in estradiol-primed rats than in non-primed rats when expressed as percent inhibition of control prolactin release. The results suggest that talipexole and SND 919 have a selective dopamine D-2 receptor agonistic property and are almost completely effective to counteract the enhancement of prolactin release induced by estrogens via stimulation of dopamine D-2 receptors in the anterior pituitary.

Animals↗