PubMed Health⌕ Search

Biomedical subjects

Y Hanamure

Publications and source records attributed to Y Hanamure.

28 records · Page 2Linked to original sources
PubMed1991

[Gastric mucosa investigated by endoscopic biopsy and functional study].

This study investigated the relationship between the gastric mucosa, gastric emptying and the peroral iron loading test in gastric ulcer and gastric cancer cases. The gastric mucosa in gastric ulcer cases was similar to that in gastric cancer cases. Gastric emptying in the M portion was delayed more than in the C and A portions as well as in the control group. In both early and advanced gastric cancer cases, gastric emptying was delayed slightly more than in the control group. The results of the peroral iron loading test showed that the serum iron level in the gastric ulcer cases in the active stage increased more remarkably than in the healing stage. In early gastric cancer cases the results of the peroral iron loading test were similar to those of the gastric ulcer cases. In advanced gastric cancer cases, the quantity of the serum iron did not increase significantly. In both gastric ulcer and gastric cancer cases, the quantity of serum iron in the cases with anemia was significantly increased. In both gastric ulcer and gastric cancer cases, negative correlation was recognized between serum ferritin and an increased quantity of serum iron. In gastric ulcer cases on the M portion, positive correlation was recognized between the increased quantity of serum iron and gastric emptying. In both gastric ulcer and gastric cancer cases, the increased quantity of serum iron in cases with severe atrophic gastric mucosa was more significant than in those with mild atrophic gastric mucosa.

Atrophy↗
PubMed1983

[Experimental and clinical studies of cefotiam for the treatment of otorhinolaryngological infections].

Basic and clinical studies on cefotiam (CTM) for the infectious diseases in otorhinolaryngological field were performed and the following results were obtained. The peak value in the serum level of CTM was 18.05 micrograms/ml by 0.5 g administration and 35.2 micrograms/ml by 1 g at 30 minutes after a single intravenous injection. CTM was rapidly excreted from the blood after injection and was detected a little amount in serum at 6 hours after the administration. Tissue concentrations of the drug into palatine tonsil and the mucous membrane of the nasal cavity or maxillary sinus were seen in relatively rapid and good manner. Chemotherapeutic results excepting Pseudomonas aeruginosa infections (3 cases) were excellent in 2 cases, good in 7 cases and poor in 3 cases of 12 patients with the infectious diseases in otorhinolaryngological field. No adverse effects and abnormal values in the laboratory findings were revealed in every patients.

Adolescent↗
PubMed1983

[Clinical evaluation of ototoxicity associated with intravenous drip infusion of amikacin].

On the 53 patients with ENT (ears, nose, and throat) diseases, ototoxicity after intravenous drip infusion of amikacin (Biklin AMK) was studied. Each dose of AMK was 400 mg/day in adults and 4--8 mg/kg/day in children. From audiometric analysis, there were no patients with any hearing disturbances and subjective complaints concerning labyrinth injury. Also abnormal laboratory findings were not found in them. An intravenous drip infusion of AMK in adequate dosage would be beneficial to use against some infectious diseases of otorhinolaryngologic field.

Adolescent↗
PubMedDate not supplied

Establishment of human mucosal microvascular endothelial cells from inferior turbinate in culture.

Human microvascular endothelial cells were isolated and cultured from the mucosa of inferior turbinates. Using dish-coated collagen and a medium composed of a 1:1 mixture of sarcoma 180-conditioned medium and Dulbecco's modified Eagle's medium (containing 10% fetal bovine serum and 75 micrograms/mL endothelial cell growth factors prepared from bovine pituitary glands), these cells grew rapidly to confluence and survived serial passages until the 16th population doubling level. The cells were identified as endothelial cells by their morphology, immunostaining of factor VIII antigen, and cytochemical staining with Ulex europeus agglutinin. Furthermore, Weibel-Palade bodies and numerous pinocytotic vesicles were confirmed by electron microscopy. Proliferation experiments demonstrated the need for either endothelial cell growth factor or tumor-conditioned medium. An exogenous matrix was also required for these cells in tissue culture. A tubule-like morphology appeared in the original monolayer of human microvascular endothelial cells after 1 month in the same plate, indicating that these cells have the ability to form tubules in the presence of sarcoma 180-conditioned medium.

Cell Division↗
PubMedDate not supplied

Normal distribution of lysozyme- and lactoferrin-secreting cells in the chinchilla tubotympanum.

The distribution of the antibacterial enzyme lysozyme- and lactoferrin-secreting cells in the tubotympanum of normal chinchillas was studied using an immunohistochemical technique. The middle ear mucosa contained lysozyme-secreting cells and lactoferrin-secreting cells. The former were localized primarily in the columnar epithelium area and the latter primarily in the cuboidal epithelium area (that contains serous cells) of the transitional zone. In the eustachian tube, the lysozyme was localized in goblet cells of the mucosal epithelium and mucous cells of the glands, while lactoferrin was localized in serous cells of the glands. Our results indicate that secretory lysozyme and lactoferrin are secreted by different cell types (mucous or serous), supporting the notion of heterogeneity of the secretory cells of the tubotympanum. This finding is consistent with the concept that antibacterial enzyme secretion is an integral part of the normal mucosal defense system in the tubotympanum.

Animals↗
PubMedDate not supplied

Anatomy of the chinchilla bulla and eustachian tube: I. Gross and microscopic study.

The middle ear mucosa and eustachian tube of the normal chinchilla were studied quantitatively and under light microscopy to determine the distribution of each cell type of the lining epithelium and subepithelial gland. The middle ear mucosa consisted of columnar epithelium, cuboidal epithelium, and squamous epithelium. The lining epithelium of the eustachian tube was ciliated pseudostratified columnar epithelium. These epithelia were composed of ciliated, secretory, nonciliated (nonsecretory), and basal cells. The density of the ciliated cells was highest in the columnar epithelium area of the transitional zone of the middle ear mucosa. However, the density of the secretory cells was highest in the pharyngeal orifice of the eustachian tube. The nonciliated cell density was highest in the squamous epithelium area of the middle ear mucosa and decreased progressively toward the tympanic orifice of the eustachian tube. In the eustachian tube, the nonciliated cell density was highest in the pharyngeal portion of the eustachian tube, especially in the upper portion of the lateral wall. The subepithelial glands were tubuloacinar mixed glands composed of serous demilunes and mucous acini. The glands were localized primarily in the pharyngeal orifice and pharyngeal portion of the eustachian tube, and their ductal openings were present primarily in the inferior portion of the eustachian tube.

Animals↗
PubMedDate not supplied

Structural organization of the outer hair cell wall.

The lateral wall of the mammalian outer hair cell has specialized structures composed of "subplasma lamina" and "micropillars." These structures anchor the subsurface cisternae to the inner leaflet of the cell membrane. The micropillars are arranged in parallel arrays encircling the entire inner side of the outer hair cell. The subplasma lamina appears sheet-like with rows of indentations and ridges in parallel arrays or in grid patterns among the specimens prepared for scanning electron microscopy. It is interpreted that these indentations are formed by the loss of the micropillars due to the osmium digestion. It is suggested that the subplasma lamina and micropillars may provide a rigid structure of the cylindrical shape and also may be involved in the motile activity of the outer hair cell.

Animals↗