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Y Handa

Publications and source records attributed to Y Handa.

257 records · Page 15Linked to original sources
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Spiny keratoderma of the palms and soles - report of two cases.

We report two patients with spiny keratoderma of the palms and soles characterized by multiple tiny keratotic plugs on the palms and soles. This disease was reported to be possibly associated with internal malignancies. We found a tumor from the esophagus to cardia in one patient. Another had no tumor but the lesion occurred soon after a severe bronchial asthma attack. Causal relation between spiny keratoderma of the palms and soles and bronchial asthma is obscure. Since this disease has been under-diagnosed and under-reported, it is important for dermatologists to keep spiny keratoderma of the palms and soles in mind in daily clinical examinations.

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An immunohistochemical and ultrastructural study of cultured intracranial hemangiopericytoma.

Surgically excised intracranial hemangiopericytomas from three patients were cultured in vitro and they were examined by immunohistochemistry and electron microscopy to trace the origin of intracranial hemangiopericytomas compared to meningiomas. In all of the three hemangiopericytoma cell cultures, the matrix stained positively for vimentin and desmin. Two stained positive for actin and laminin. Cultured meningioma cells were positive in vimentin staining but negative in others. Hemangiopericytomas continued to have prominent intracytoplasmic intermediate filaments, microfilaments forming dense bodies and pinocytotic vesicles. Reconstruction of only a few cell junctions of zonula adherens type after subcultivation were observed in hemangiopericytoma, while there were neither whorl formations nor cell junctions found, such as desmosomes and junctional complexes, which are common in cultured meningioma cells. These results suggest that intracranial hemangiopericytoma has something in common with muscle cell, endothelial cell and fibroblast which form the vascular and perivascular tissues, and it is distinguishable from meningioma.

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