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Biomedical subjects

Y Hiji

Publications and source records attributed to Y Hiji.

18 recordsLinked to original sources
PubMed1987

Enhancement of local anaesthesia action by organic acid salts. (I): Possible change of excitability in nerve fibre membrane.

Measurements of action potentials recorded from giant nerve fibres of the crayfish abdomen showed that by addition of an organic acid salt to a local anaesthetic solution, the onset of anaesthetic action became more rapid and the duration of action was prolonged. Similar results were also obtained in rat vagal nerves. The chemical structure of compounds having these enhancing effects was found to have, in common, a carboxyl group connected with either a benzene ring or an aliphatic hydrocarbon. Topical application of anaesthetic solutions to the skin of flexor side of the forearm in humans revealed that the duration of anaesthesia evaluated by the apparent decrease of the number of pain points was significantly prolonged by the addition of salicylate. The use of local anaesthetics combined with organic acid salts would be promising in clinical practice to enhance their action greatly.

Action Potentials↗
PubMed1979

Effects of nickel ion on the conduction of action potentials in non-myelinated nerve fibre of crayfish.

Effects of NiCL2 and PCMB (p-chloromercuribenzoate) on the action potential were examined by the method of extra- and intracellular electrodes, using a single nerve fibre of crayfish. The results obtained were as follows : The conduction of the action potential was blocked by treating the nerve fibre with Ni ion or PCMB. The blockade was easily recovered by replacement with cysteine. The process of the blockade and recovery, which could be repeated several times, was fairly characteristic such that the more repetition led the sooner blockade and the harder recovery. No conduction block was observed by treatment with Ni-cysteine mixed solution nor with PCMB-cysteine solution. The critical concentration for blocking was 1.1 x 10(-4)M for NiCL2 and 5.6 x 10(-6) M for PCMB. The action potential was disappeared without any change in the resting potential by treatment with the chemicals, which gave significant effects on the rising and falling phases of the action potential before the blockade.

Action Potentials↗
PubMed1978

Dynamic dialysis utilizing a hollow fibre unit as a rapid method for studying protein binding.

A useful approach for determining the binding ability which occurres in a protein-small molecule system was studied by a method of dynamic dialysis utilizing a hollow fibre unit. A dependency on experimental variables in the absence of protein was examined in order to characterize the nature of the dialytic process. It was shown that the rate of small molecule escaped across the dialytic membrane was dependent on stirring or flowing rate, temperature and pH, but independent on buffer strength or viscosity. The protein binding ability was examined by means of comparing amounts of small molecules in the absence and presence of protein. Kinetic parameters for the binding behaviour analysed from the Scatchard plot in the present experiment were in agreement with values previously reported.

Azo Compounds↗