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Biomedical subjects

Y Hirade

Publications and source records attributed to Y Hirade.

11 recordsLinked to original sources
PubMed1990

[Relationships between the degree of lesion and that of vocal dysfunction in vocal fold polyp].

Relationships between the degree of lesion and that of vocal dysfunction were investigated in 122 cases of vocal fold polyp. A normalized size of polyps and glottic gap were correlated to the results of phonatory ability tests, stroboscopic investigations, acoustic analyses, and perceptual evaluations. There was no significant correlation between the size and the gap. The size of polyp was negatively correlated to fundamental frequency, whereas it was positively correlated to roughness of voice, asymmetry of vocal fold vibration, irregularity of vocal fold vibration, pitch perturbation quotient, amplitude perturbation quotient, and normalized noise energy. The glottic gap showed negative correlations to maximum phonation time and sound pressure level, and positive correlations to mean airflow rate and fundamental frequency.

Adult↗
PubMed1989

Improved surgical technique for epidermoid cysts of the vocal fold.

An improved surgical technique for epidermoid cysts of the vocal fold is presented. This technique employs a specially designed double-bladed elevator. Following betamethasone injection around the cyst, an incision is made posterior to the cyst at its mediolateral midpoint. The incision is extended anteriorly over the cyst with the use of a double-bladed elevator. The cyst then is elevated carefully from the surrounding tissue and removed. A single incision line on the upper aspect of the vocal fold should be the result. Eight patients were operated on with the present technique. The voice was improved postoperatively in all patients. The voice improvement was reflected objectively in stroboscopic findings, maximum phonation time, airflow rate, fundamental frequency and intensity of phonation, and results of acoustic analyses of voice.

Adult↗
PubMed1988

CO2 laser for treating glottic carcinoma.

Fifty cases of glottic carcinomas treated with CO2 laser were reviewed. The recurrence rate was fairly high (19/50), especially in T1b and T2 cases. The recurrences were successfully treated in all but 1 case who refused treatment. The 3-year crude survival rate was 92% and the 3-year determinate survival rate was 98%. The ultimate voice conservation rate was 100% for T1a, 76% for T1b and 71% for T2 cases. The results led us to the following conclusion: (1) glottic T1a carcinomas can be eradicated with laser excision biopsy preserving good vocal function; (2) for glottic T1b and selected cases of T2, laser debulking followed by radiotherapy is one of the best choices of treatment.

Follow-Up Studies↗
PubMed1988

[Preservation surgery of head and neck cancer. Results and postsurgical function].

The purpose of conservation surgery is to eradicate the cancerous lesion while preserving the morphology and function of the affected organ as much as possible. Many important functions including swallowing, phonation and articulation are carried out by the organs in the head and neck. This paper presents the short-term (2 years) results of conservation surgery for carcinomas of the tongue, oropharynx, hypopharynx and larynx. Long-term results await further follow-up because of the fact that we started full use of conservation surgery rather recently. Three types of conservation surgery were applied for cancer of the tongue in 36 cases:laser surgery alone, laser debulking surgery followed by (chemo) radiotherapy and induction chemotherapy followed by laser debulking surgery and radiotherapy. The local control rate and survival rate were 97% and 88%, respectively. The basic principles of conservation surgery for oropharyngeal cancer were the same as those for cancer of the tongue. A total of 23 patients were treated, yielding a 65% local control rate and a 63% survival rate. For hypopharyngeal cancer, two types of conservation surgery were applied:partial pharyngectomy and partial laryngopharyngectomy. A total of 10 patients underwent these procedures. The local control rate was 60% and the survival rate was 70%. Two major groups of conservation surgery were applied for cancer of the larynx:laser surgery with or without radiotherapy in 74 cases and partial laryngectomy in 94 cases. The local control rate was 69% for laser surgery and 87% for partial laryngectomy, while the survival rates were 100% and 91%, respectively.

Combined Modality Therapy↗
PubMed1985

[CO2 laser in treating head and neck cancer].

CO2 laser is especially useful in treating cancer of tube- and cavity-organs. For carcinomas of the tongue, we have employed three types of laser usage. Carcinomas confined within the mucosa are treated by laser alone. For carcinomas invading the muscle to some extent, we make a mass reduction surgery by means of laser which is followed by (chemo)radiotherapy. Carcinomas with extensive muscular invasion are first treated with induction chemotherapy. If the chemotherapy is effective, we add laser surgery for the purpose of mass reduction and chemoradiotherapy follows. 26 patients were treated and none has developed local recurrence. For glottic carcinomas, we have applied laser in two ways: laser surgery alone and laser combined with (chemo)radiotherapy. We have treated 58 patients with glottic carcinoma. 14 developed local recurrence. Of these 14, 13 were successfully treated but the other died because he refused to have further treatment.

Antineoplastic Agents↗
PubMed1983

Epithelial hyperplasia of the larynx. A 10-year review of 88 patients.

A retrospective review of 88 patients with epithelial hyperplasia of the larynx seen at the Department of Otolaryngology Kurume University during the 10-year period from 1971 to 1980 was completed. The results are summarized as follows: 1) The incidence was much higher in males (78 patients) than in females (10 patients). 2) The average age was 56.8 years. 3) The lesion was located on the vocal fold in 84 cases, the ventricular fold in 3, and both vocal and ventricular folds in 1. 4) Fifty-three patients underwent surgical treatments in our hospital. Three of them developed recurrence and 6 developed carcinoma. 5) On histological re-examination, the lesions were classified into three types: simple hyperplasia (Type I), dysplasia (Type II) and carcinoma (Type III). No relationship was found between the macroscopic appearance and the histological type.

Adult↗
PubMedDate not supplied

Acoustic analysis of pathological voice. Some results of clinical application.

Tape-recorded voices of 30 patients were acoustically analysed: 10 had glottic Tla carcinoma, 10 unilateral vocal fold polyp and 10 unilateral recurrent laryngeal nerve paralysis. The carcinoma cases were treated with laser surgery with/without radiotherapy, the polyp cases with endolaryngeal microsurgery and the paralysis cases with intrafold silicone injection. The acoustic analysis was conducted before and after the treatment for each patient. Three acoustic parameters, viz. pitch perturbation quotient (PPQ), amplitude perturbation quotient (APQ) and normalized noise energy (NNE), were employed. The results were as follows: (1) PPQ and APQ were greater in paralysis cases than in carcinoma and polyp cases; (2) none of the parameters was useful in differentiating the three disease groups investigated; (3) all three parameters proved to be useful in monitoring the effects of treatments; (4) all three parameters were positively correlated to the grade of hoarseness, rough and breathy quality of hoarseness, mean airflow rate and regularity of vocal fold vibration viewed under stroboscopy; (5) PPQ, APQ and NNE were positively related to each other.

Aged↗
PubMedDate not supplied

Vocal function following carbon dioxide laser surgery for glottic carcinoma.

Vocal function following laser surgery for glottic T1a carcinoma was evaluated in 17 patients and compared to vocal function following radiotherapy in 14 patients. The results are summarized as follows. 1) A slight degree of hoarseness was found more frequently following laser surgery than following radiotherapy. The quality of hoarseness was rough and breathy in most cases. 2) In stroboscopic examination, incomplete glottal closure and diminution or lack of vibration of the operated vocal fold were frequently observed following laser surgery. 3) There was no marked difference in maximum phonation time, mean airflow rate, fundamental frequency range of phonation, intensity range of phonation, and intensity-flow ratio between the laser and the radiotherapy groups. On the basis of these results, we conclude that there is little difference in vocal function between postlaser and postradiotherapy patients as far as conversational voice is concerned.

Adult↗