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Y Hishikawa

Publications and source records attributed to Y Hishikawa.

8 recordsLinked to original sources
PubMed1977

[Index of fibrinolysis with new fibrin plate (author's transl)].

Plasminogen-free fibrin plate (fP) which was made from treated commerical bovine fibrinogen with Lysine-Sepharose was developed in our laboratory. This new fibrin plate showed the following specificities. a) This new fibrin plate did not show any lysis with high amount of streptokinase and Urokinase (10,000 u/ml and 500 u/ml). b) The concentrations of its substrate was the same as standard plate (SP) and its substrate was not denatured compared with heated plate (HP). c) The activity of plasmin can be measured quantitatively on fP and linear correlation between plasmin units and lysis area was showen. d) This procedure of new fibrin plate was easy and simple and could be applicable to the materials of other species, i.e., human, rabbit and porcine. With the use of two kinds of bovine fibrin plate (SP and fP), activation of fibrinolysis of human plasma, euglobulin and plasminogen induced by SK and UK was investigated and each correlation ship between sample and activator was studied statistically. From these results, "Index of fibrinolysis" meaning of fibrinolytic components such as plasmin, plasminogen, activator, proactivator, anti-activator and anti-plasmin were indicated. Indeed, these index of fibrinolysis were calculated from the lysis area of plasma+SK, Eug.+SK and Eug.+UK by each formula and index obtained from some physiological and pathological condition showed us many new information about fibrinolysis.

Animals↗
PubMed1976

Sleep satiation in narcoleptic patients.

UNLABELLED: Polygraphic sleep recording was performed in 20 narcoleptics with one or more of the auxiliary symptoms, 4 narcoleptics with only sleep attacks and 10 normals during one night and into the following day. Total sleep time in the narcoleptics did not differ significantly from that in the normals. Sleep of the narcoleptics with auxiliary symptoms was unstable with frequent awakening. The temporal organization of the REM--NREM sleep cycle was irregular in the narcoleptics with auxiliary symptoms, compared with those in the other two groups. Percentage of Stage 1 was significantly larger in the narcoleptics with auxiliary symptoms than in the other two groups and percentage of Stage 2 was smaller. Percentage of Stage 4 was smaller in the narcoleptics with auxiliary symptoms than in those with only sleep attacks. Percentages of Stages 3 and REM did not differentiate the three groups. Spindle density during Stage 2 did not differentiate the three groups. Sleep onset Stage REM was frequently observed exclusively in the narcoleptics with auxiliary symptoms. Excluding the instances showing sleep onset Stage REM, mean latency of initial episodes of REM sleep in the three groups was shorter after daytime sleep onset than after nighttime sleep onset. In the narcoleptics with auxiliary symptoms, no significant correlation was found between the percentage of Stage REM and clinical findings. CONCLUSIONS: the sleep attacks in narcoleptics are due to an ill-timed, strong tendency to fall asleep (including both REM and NREM sleep), and it is therefore suggested that they are manifestations of their disturbed circadian rhythm of sleep--wakefulness cycle.

Adolescent↗