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Biomedical subjects

Y Horn

Publications and source records attributed to Y Horn.

At least 55 records · Page 3Linked to original sources
PubMed1982

Further evidence for the use of polyamines as biochemical markers for malignant tumors.

One hundred ninety patients with a variety of tumor presented within a specified time period and fit a specified protocol. Multiple serial urinary putrescine, spermidine, and spermine levels were obtained in these patients, and their disease activity over time, defined as either active or nonactive, was determined by clinical examination, the results of laboratory tests, and radiological criteria. Twenty-four-hr urine collections were used for analysis of polyamine levels. A linear mixed-effects model and the method of maximum likelihood estimation were used for statistical analysis. Statistically significant differences were found in polyamine levels between patients with active or nonactive disease for tumors of the breast, stomach, prostate, female genital tract, and a variety of metastatic carcinomas of unknown origin. There were 105 patients with these tumors; 319 polyamine determinations were obtained from this subset of patients. Our results suggest that serial determination of polyamine levels in urine may have clinical utility for monitoring the disease states for these tumors.

Breast Neoplasms↗
PubMed1982

CEA levels in active and non-active malignant tumors.

A total of 895 CEA estimations were carried out on serum samples from 283 patients with different primary tumor sites. All assays were performed during the period of follow up or treatment of the patients. Concomitantly with CEA estimation, activity of disease was recorded, based on objective laboratory and clinical parameters. The results obtained proved a high accuracy rate for normal CEA values in non-active disease as well as elevated CEA values in active disease. It is concluded that the correlation between CEA level and activity of disease in various neoplasms in an important aid in clinical decision making during the course of disease, provided false positive or negative results are taken into consideration.

Carcinoembryonic Antigen↗
PubMed1981

Leukocyte alkaline phosphatase in cancer patient.

Leukocyte alkaline phosphatase (LAP) activity in peripheral blood was determined in 113 patients with non-metastatic malignancies, 36 patients with metastatic spread, and 22 individuals who served as controls. The LAP score of the non-metastatic cancer patients was significantly higher (p less than 0.001) than the controls, and the score of the metastatic group was further increased significantly as compared to both control (p less than 0.001) and non-metastatic groups (p less than 0.001). The results of this survey suggest that the level of LAP score in peripheral blood might be used to differentiate between non-metastatic and metastatic disease and might serve as an aid in prognosis of the patients.

Alkaline Phosphatase↗
PubMed1979

Effect of irradiation-timing on the initial socket healing in rats.

The effect of a single dose of 1500 R on early postextraction socket healing was studied in jaws of rats. A severe delay in healing was found in animals irradiated 2 weeks prior to extraction. Retardation of healing to a lesser degree was demonstrated in sockets irradiated immediately after exodontia.

Alveolar Process↗
PubMed1978

Correlations between geometrical parameters measured on liver scintigrams and clinical observations.

Various geometrical data, resulting from anterior scans, of both normal and pathological livers were classified and analyzed statistically from two points of view: Firstly, a static study resulting from observations on pooled scans. This study showed that the frequency distributions of some geometrical parameters in the liver are essentially normal in character. It equally demonstrated that the dimensions of the parameters depend on the degree of the pathology of the liver. Secondly, a study which was carried out on repeated scans recorded on the same patient. It showed that the relative variations of some geometrical parameters of the liver are a function of its degree of pathology, whatever the types of abnormalities considered. The definition of a variable is suggested, the knowledge of which can help to establish the diagnosis.

Adult↗
PubMed1977

Single versus fractionated doses of X-radiation and their effect on mammary carcinoma in the rat.

Selective destruction of neoplastic tissue by X-radiation, delivered as a single pulse or as a series of fractions, was investigated in transplanted DMBA-induced rat mammary tumors. Dosage was based on Strandqvist's fractionation curve, and compared with nominal standard doses. Tumor growth was most effectively inhibited when radiation was divided into three fractions. These results are consistent with predictions based on the NSD formula, rather than with the expected isoeffect of Strandqvist's curve. The higher doses of the three fractions were significantly more effective.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1976

Temporary external valve drainage in hydrocephalus with increased ventricular fluid pressure. (Experiences with 202 cases). (Experiences with 202 cases).

When the ventricular fluid pressure has reached a level of 120 to 150 mm H2O, there is a risk of rapid internal herniation. The effects of corticoids and hyperosmolar drugs on this are not as striking as they are on brain oedema. The only efficient therapy is the establishment of an external ventricular drainage system proposed for the first time in 1941 by Ingraham and Campbell and regulated with a valve system by White et al. 1967. From our experience of 202 cases we review the technique, the indications, and the complications of ED.

Brain Neoplasms↗
PubMed1976

Male breast cancer: two cases with objective regressions from calusterone (7 alpha, 17 beta-dimethyltestosterone) after failure of orchiectomy.

Calusterone (7 alpha, 17beta-dimethyltestosterone) is an orally effective weakly androgenic steroid. The antitumor efficacy of calusterone, 200 mg per day against objectively progressing advanced breast cancer in females has already been reported. In the present study calusterone was used in metastatic breast cancer in two male patients. Both had failed to continue respond to orchiectomy and had measurable lesions one in the lungs, the other in the bones. Both patients showed objective regression (blastic response of osteolytic lesions and disappearance of lung metastases) lasting five months in one patients and more than seven months in the other, who is still in regression. Further experience is necessary for statistically adequate results.

Adenocarcinoma, Papillary↗
PubMed1975

Experience with contrast mammography in the diagnosis of various breast diseases.

Contrast mammography, with oxygen or positive contrast material, was performed on 88 women with various diseases of the breast. The examination was done after simple mammography had failed to establish a clear diagnosis. In each case, the roentgenologic diagnosis was confirmed by histological examination. In some cases, bicontrast studies of the duct system or of cysts were performed. With contrast mammography, a correct diagnosis was established in 98.7% of malignant tumors and in 97.8% of benign tumors. Bicontrast studies demonstrated intraductal and intracystic malignancies.

Adenofibroma↗