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Biomedical subjects

Y Huo

Publications and source records attributed to Y Huo.

49 records · Page 3Linked to original sources
PubMed1996

[Coronary angiographic characteristics of patients with unstable angina].

In order to study the characteristics of coronary lesions of patients with unstable angina, coronary angiograms and clinical manifestations were analysed on 388 patients. The results were as follows: single vessele disease was more common in new onset effort angina (69.64%) than in other groups (P < 0.05). Triple vessele disease and left main coronary artery lesion appeared more frequently in patients with rest angina than in other groups (72.34% and 27.66% respectively, P < 0.05), so did complex lesions and type C lesions (36.07% and 60.64% respectively, P < 0.05). More than half of the culprit lesions in early postinfarction angina was subtotal or total occlusions (53.12%), being more frequently found in this than in other groups (P < 0.05). Most of the patients with Prinzmetal variant angina had mild coronary lesions only. Coronary thrombi were found in 10.45% of the 388 patients; they were was more frequent in patients with early postinfarction angina (20.00%) than in the groups of new onset effort angina, aggravated effort angina and Prinzmetal variant angina (4.26%, 7.53% and 0% respectively, P < 0.05). Coronary thrombi were also more frequent in the patients with chest pain at rest (16.39%) than in the groups of new onset effort angina and Prinzmetal variant angina (P < 0.05). It is suggested that patients with angina at rest should be treated more intensively. Strengthened anticoagulation treatment should be given to patients with early postinfarction angina and angina at rest.

Adult↗
PubMed1996

[Study of relationship between the bacteria in air and the clinic infection].

The Source of infectious bacteria is the first problem in provension of infection considered by the medical workers. In this paper, with the method of bacteria plasmid analysis, chromosome DNA restriction fragment length polymorphism analysis, drug resistance experiment (antibacterial drug, sterilizing drug) and so on. We confirmed that staphylococci of nosocomi is mainly from air; but the gram-negative bacteria is mainly from the patient's pharyngeal portion; and cause hospital infection indirectly. The drug resistance of gram-negative from air was lower than the same gram-negative bacilli's isolated from the patient. Moreover, kill bacteria the infectious strain is same strain in air. Above-mentioed results provided the important basis for control of the hoslpital infection.

Air Microbiology↗
PubMed1995

[A preliminary study on the inhibitory action of target-primaqine on the exoerythrocytic forms of Plasmodium yoelii yoelii].

Target-primaquine (TPQ)--the primaquine entrapped by galactosylneoglycoalbumin (G-NGA), was given intravenously (iv) to Wistar rats 2 h after sporozoite inoculation. The sporozoite viability (SPV) of TPQ 20 mg/kg group was revealed to be 1.2% 42 h after inoculation, which showed a decline of about 6% as compared to the control; besides, degeneration or retardation of development was present in 90% of EEF. In TPQ 10 mg/kg and PQ 20 mg/kg groups, the SPV were 2.8% and 5.0%, respectively, showing drops by 15% and 26% as compared with that of the control. Degeneration or retardation in development was also visible in about half of the EEF. In mice which were treated iv with TPQ 10 mg/kg or PQ 20 mg/kg 2 h after sporozoite inoculation, the prepatent periods were delayed markedly as compared with that of the control. Parasitemia did not appear in 2 mice in 10 mg/kg TPQ group further indicated the effectiveness of the drug. The results suggest that the anti-EEF effect of TPQ is apparently more promising than that of PQ.

Albumins↗
PubMed1995

[Percutanous transluminal coronary angioplasty for unstable angina].

Percutanous transluminal coronary angioplasty (PTCA) was performed in 190 patients with 250 diseased vessels and 278 lesions from Dec. 1987 to Feb. 1994. All the patients had unstable angina (UA). There were 52 (18.7%) type A lesions, 175 (62.9%) type B lesions and 51 (18.3%) type C lesions. Of the 190 patients undergoing PTCA, 134 (70.5%) patients had dilatation of a single vessel, 46 (24.2%) of two vessels and 10 (5.3%) of three or more vessels. In 121 patients with multivessel disease, 98 (81.0%) had incomplete revascularization of the ischemia-related vessel (the culprit vessel) and only 23 (19.0%) had complete vessel revascularization. Kissing balloon technique was used in six patients and autoperfusion balloon in five. There were four patients undergoing directional coronary atherectomy (DCA) and four intracoronary stent. The clinical (patient) success rate was 94.7% (180/190) and technical (vessel) success rate 95.2% (238/250). The average degree of vessel stenosis was 88.7% +/- 8.3% before PTCA and the residual tenosis was 17.9% +/- 9.2% after PTCA. Acute vascular complications occurred in 18 (6.5%) lesions. 15 were managed successfully, two developed Q wave myocardial infarct and one died. None needed emergency coronary bypass operation. PTCA was not successful in 10 patients. In 180 patients with successful PTCA, 165 (91.7%) were free from UA, 15 (8.3%) patients had symptoms improved and oxygen need reduced. During a six-month follow-up, 26 patients had chest pain again with confirmed restenosis, repeated PTCA was performed successfully.

Adult↗
PubMed1994

A pulsed-field gel electrophoresis map in the ataxia-telangiectasia region of chromosome 11q22.3.

Our interest in isolating the gene(s) for ataxia-telangiectasia has prompted us to construct a physical map of chromosome 11q22.3 using markers localized to this region by linkage analysis and/or hybrid cell panels. Twenty-two markers have been analyzed by pulsed-field gel electrophoresis. Nine of these markers form an approximately 2-Mb long-range contiguous map. An average distance of 200 kb between probes in this map should facilitate the isolation of new cDNAs, anonymous probes, and YACs in an orderly way.

Ataxia Telangiectasia↗
PubMed1994

Percutaneous transluminal coronary angioplasty. Its success rate and affecting factors.

From December 1987 to October 1983, percutaneous transluminal coronary angioplasty (PTCA) was performed in 302 patients with 392 diseased vessels and 440 lesions. The success rate was 93.71% in 302 patients, 94.90% in 392 diseased vessels and 95.00% in 440 lesions. The success rate was 98.92% in Type A lesion, 95.71% in Type B lesion, and 86.57% in Type C lesion (A vs B P = NS, A vs C P < 0.01). There were 55 lesions with total or subtotal occlusion, the success rate was 89.09% (93.10% in Type B lesion and 84.62% in Type C lesion). As to the diseased vessels, the success rate was 95.65% in LAD, 94.38% in LCX and 93.75% in RCA. The results showed no significant difference. In this series, acute ischemic complications were found in 6.59% (29/440). Of these 29 lesions, 23 were treated successfully, 5 developed Q wave myocardial infarction and 1 died.

Aged↗
PubMed1994

Ataxia-telangiectasia: flow cytometric cell-cycle analysis of lymphoblastoid cell lines in G2/M before and after gamma-irradiation.

It has been estimated that 1 to 3% of the general population may be ataxia-telangiectasia (A-T) heterozygotes and hypersensitive to conventional doses of radiation. We attempted to identify heterozygotes by evaluating the proportion of cells in various phases of the cell cycle in response to irradiation. This was accomplished by using flow cytometry to study lymphoblastoid cell lines (LCLs) from 14 A-T homozygotes, 17 genotypic A-T heterozygotes, and 18 normal individuals, including 10 genotypic normals. The LCLs were exposed to 2-gRay radiation and were analyzed after 24 hr along with nonirradiated controls. The difference between the percentage of cells in G2/M with and without irradiation after 24 hr ranged, respectively, from: 12.0 to 31.5% (mean = 18.7 +/- 5.5) for A-T homozygotes; 6.7 to 19.3% (mean = 12.5 +/- 3.8) for A-T heterozygotes; and -1.5 to 12.4% (mean = 6.4 +/- 3.2) for normals. A cut-off region of 9.6 to 13.2% defined by one standard deviation above the mean for normals and one standard deviation below the mean for A-T homozygotes served as the grey zone between normals and A-T heterozygotes or homozygotes. Two of the 18 normals overlapped with the grey zone. Four of 17 heterozygotes were within the normal range; seven fell within the grey zone. This may reflect nongenetic variables, such as the status of the LCLs at the time of testing. Flow cytometry cell-cycle analysis on irradiated LCLs is a useful adjunctive test for establishing a diagnosis of A-T in questionable cases.(ABSTRACT TRUNCATED AT 250 WORDS)

Ataxia Telangiectasia↗
PubMed1992

[Thixotropic properties of whole blood in children with congenital heart disease].

The thixotropic parameters of whole blood in two groups of children with congenital heart disease (CHD) were measured. Group 1. cyanotic heart disease (CCHD), 20 cases; Group 2. acyanotic heart disease (ACHD), 30 cases. Fifty healthy children were controls matched with the patients in sex and age. Their thixotropic parameters were compared; the paired t-test was used. In the children with CCHD, the hematocrit (HCT), the yield stress (tau 0) the Newtonian contribution of viscosity (mu), the equilibrium value of the structural parameter (A), the apparent viscosity at 2.37 sec-1 (eta s) and the Non-Newtonian contribution of viscosity (eta s-mu) were significantly higher than those in corresponding control groups. In the children with ACHD, only the values of tau 0, eta s-mu, and eta s were higher than those in control groups. All of the thixotropic parameters in CCHD group were significantly higher than those in ACHD group. Thus we described quantitatively CHD in terms of thixotropy of blood. The thixotropic parameters of blood could be used as indexes of severity for pathologic changes of CHD.

Adolescent↗
PubMed1991

Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.

Linkage of at least two complementation groups of ataxia-telangiectasia (AT) to the chromosomal region 11q23 is now well established. We provide here an 18-point map of the surrounding genomic region, derived from linkage analysis of 40 CEPH families. On the basis of this map, 111 AT families from Turkey, Israel, England, Italy, and the United States were analyzed, localizing the AT gene(s) to an 8-cM sex-averaged interval between the markers STMY and D11S132/NCAM. A new Monte Carlo method for computing approximate location scores estimates this location as being at least 10(8) times more likely than the next most likely interval, with a support interval midway between STMY and D11S132 that is either 5.2 cM (sex-averaged and conservatively based on 3 lod scores from the maximum-location score) or 2.8 cM (male specific, based on a 2.72:1 interval-specific female-to-male distance ratio.

Ataxia Telangiectasia↗
PubMed1991

[Study on thixotropic parameters of whole blood from healthy children].

With low shear-30 rheometer, the authors used a modified protocol to measure thixotropic parameters of whole blood from 200 healthy newborns and children, so as to suggest the normal range of blood thixotropic parameters in four age groups, namely, the newborns, 1 year- group, 5 year- and 10-15 year group. The results demonstrated that the thixotropic parameters in the newborn group were higher than those in other three groups. However, these thixotropic parameters in the group 1-10 years were lower than those in the 10-15 year group. No significant sex differences were noted among the fore three groups, but sex differences appeared obviously in the 10-15 year group. It implied that the changes relying on the age is consistent with children's growth, development and physiologic activities.

Adolescent↗