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Biomedical subjects

Y Hyo

Publications and source records attributed to Y Hyo.

17 recordsLinked to original sources
PubMed1992

[A case of verrucous carcinoma showing a good partial response by C.P.E. (CDDP, PEP, etoposide) chemotherapy].

A 60-year-old woman was admitted to our hospital with a complaint of rough feeling on the oral mucosa and diagnosed as verrucous carcinoma with histopathological examination. She was treated with CPE chemotherapy, and showed a good response and improvement of clinical symptoms. Toxicities were leukopenia, alopecia and anorexia. However, these were slight side effects. The patient is currently healthy with no recurrence after two years and 3 months. CPE chemotherapy is considered to be effective for a patient with verrucous carcinoma.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

[Clinical study on mandibular condylar fracture. 1. Retrospective study in 100 patients with 130 temporomandibular joint fractures with special consideration in the treatment for the various locations and forms of the fractures].

Clinical retrospective investigation was conducted on mandibular condylar fractures of 100 hospitalized cases at the Department of Oral Surgery, Kyoto University Hospital during the period from 1973 to 1983. The following results were obtained, 1. There were 74 males and 26 females. The age of the patients at the time of injury ranged from 4 to 78 years old. The average age was 28.1 years old. 2. Twenty-six patients were treated within a week of injury, 22 cases within 2-weeks and 33 cases were treated after more tham 3 weeks. 3. Of the 100 cases, 70 were unilateral fractures and 30 were bilateral. The incidence of the concomitant fractures of the mandible were higher in bilateral than in unilateral condylar fractures. 4. On fracture level and form 130-site in 100 patients were divided according to the classification of Maclennan and Kubo. Dislocated and high condylar fractures were most frequently observed. 5. Surgical reduction was mainly achieved in low neck fracture, and the contrary conservative treatment was observed in the higher level fracture. On the other hand condylectomy was infrequently indicated in the dislocated head fracture.

Adolescent↗
PubMed1989

[Clinical study on mandibular condylar fracture. 2. Long-term follow-up study in 48 patients with 66 joints].

Sixty-six joints in 49 patients with mandibular condylar fracture were investigated by means of long-term follow-up observation. The group of patients consisted of 39 males and 10 females with ages from 15 to 75 years. The classification of the fractures was follows: MacLennan type 1; four, type 2; four, type 3; 39, and type 4; 39 joints respectively. Treatment was as follows: 25 joints were by conservative therapy, 31 joints were by surgical fixation, and 10 joints condylectomy. The follow-up period of observation ranged from 18 months to 10 years and one month an average of five years and seven months. Clinical assessment was based upon Nakatomi's dysfunction index on mandibular condylar fracture, of which the criteria are as follows; Excellent (No clinical dysfunction sign on the TMJ), Fair (Slight pain, noise, and limited range of motion of the mandible, but clinically no affected mastication), Poor (Moderate dysfunctioned jaw), and Failure (Severe dysfunctioned jaw). 23 joints in 18 patients were ranked as having excellent results. 31 joints in 22 patients were assessed as fair. Ten joints in seven patients were defined as poor, and the remaining two joints in two patients were failures. The overall success rate was 81.7%. There are no statistical differences between patient's groups based on age, sex, uni/bilateral modality, with/without other concomitant fracture, surgical/conservative procedure, location and form of fractures, and duration of period from injury. These results indicated that the conservative procedure would be the first choice as a reasonable and less invasive procedure for functional repair of mandibular condylar fracture. On the other hand, as most patients had some dysfunction sign on the TMJ after mandibular condylar fracture, a more appropriate treatment, surgical or otherwise, should be found.

Adolescent↗
PubMed1989

Particle deposition efficiency of therapeutic aerosols in the human maxillary sinus.

The deposition efficiency of therapeutic aerosol particles in the human maxillary sinus is evaluated both in the human body and in a model cast of the upper airway. In the experiments, three sample materials, such as mono-dispersed polystyrene latex particles, aqueous glucose solution and pure water, in the range of particle diameter of from 0.5 to 15.8 microns, are employed in the model cast. The radioactive labelled aerosol particle is also used in the human body. From the results of the experiment, it is confirmed that even though the maxillary sinus is a closed hollow organ, aerosol flow is able to be induced only when the pressure gradient is applied between the nasal cavity and the maxillary sinus. In this case, the particle deposition is is explained in relationship to the inertia impaction of the aerosol particles on the inside wall of the maxillary sinus. The total deposition efficiencies and the deposited particle sizes in the sinus area for both experiments, with the model and in the human body, are almost the same at 3%, and 3-10 microns in diameter, respectively. A physical model for this particle deposition suggests that these experimental values change not only with the size distributions of therapeutic particles and the pressure gradient, but also with the diameter of the sinus ostium. Moreover, since the therapeutic particle might not enter the maxillary sinus when the diameter of the sinus ostium canal is less than 1 mm, some pretreatment to open the sinus ostium canal would be necessary before applying such aerosol therapy in practice.

Aerosols↗
PubMed1987

Microsurgical treatment of patients with vestibular and cochlear symptoms.

Eighteen patients with vertigo, tinnitus, and various hearing disturbances were treated by posterior fossa exploration and microvascular decompression of the eighth cranial nerve; they were followed for more than 3 years. After successful decompression of the eighth nerve from offending vessels, the attacks of vertigo disappeared in 11 patients, improved markedly in 3 patients, and improved mildly in 4 patients. The tinnitus vanished in three patients and decreased in nine. The hearing disturbance improved in only five patients and worsened in three. Because of the satisfactory improvement of the attacks of vertigo, which are the most distressing symptoms for patients, we recommend surgical exploration for patients with severe symptoms of vestibular disturbances.

Aged↗
PubMed1982

[Compound therapy including PSK for malignant head and neck cancer].

The effect of protein-bound polysaccharide preparation, PSK was studied in 44 cases with head and neck cancer. 1) Eight cases with laryngeal cancer received radiation therapy and PSK as immunotherapy, and eight cases as control received radiation alone. During radiation, the mean values of peripheral lymphocyte counts showed statistically significant difference (P less than 0.05) between the cases with immunotherapy and those without immunotherapy. 2) Twenty-eight cases received adjuvant immunochemotherapy with Carboquone and PSK. 22 out of 28 evaluable cases in the group received adjuvant immunochemotherapy were judged as effective. These studies suggest that PSK is one of the valid immunopotentiators.

Adjuvants, Immunologic↗
PubMed1978

Malignant fibrous histiocytoma of the temporomandiblar joint. Report of a case.

A case of malignant fibrous histiocytoma of the temporomandibular joint in a 21-year-old Japanese female was presented. The patient died of the tumor with local aggressive growth but without any organ metastasis, despite the intensive treatment including radical operation of the tumor, irradiation, and chemotherapy. This case suggested that radical curative operation was the only method of the treatment for this tumor. The clinicopathological features of the tumor are discussed, making reference to the malignant fibrous histiocytoma.

Adult↗
PubMed1976

Effects of bleomycin on human tongue carcinoma cells as revealed by electron microscopy.

Five patients with tongue carcinoma were treated for 20 days with bleomycin, 15 mg/day, given by one-shot infusion through the superficial temporal artery. Specimens were taken 7, 14, and 20 days after the initial administration for light and electron microscope observations. The first alterations observed were the decrease of electron-dense chromatin clumps in nuclei and, simultaneously, the segregation of nucleolar components, i.e., amorphous protein component segregated from fibrillar and granular components. Subsequently, numerous nuclear bodies appeared in the nucleoplasm, which were observed for the first time in human tongue carcinoma cell nuclei in cases of bleomycin treatment. On the other hand, the cytoplasmic alterations were recognized by the decrease in number of mitochondria and by the appearance of numerous free ribosomes followed by the formation of tonofilaments. The cells enlarged because tonofilaments flocked together to make cancer cell nests, which were gradually together to make cancer cell nests, which were gradually transformed into a keratinic structure showing the so-called cancer pearl pattern. Finally, cancer cells were degenerated nearly to necrosis; there was no evidence of recurrence of cancer. Although the precise mechanism of the effect of bleomycin on nuclear activities of human tongue cancer cells remains unsettled because of the lack of cytochemical analysis, it is believed that bleomycin inhibits DNA synthesis and might also activate ribosomal RNA synthesis.

Bleomycin↗
PubMedDate not supplied

Ultrastructural study of mitochondria in oncocytes.

A number of mitochondria in oncocytes show pleomorphism by conventional electron microscopy. In an investigation of their stereostructure, specimens were obtained from 11 patients with Warthin's tumor, parts of which were used in the preparation of serial thin sections. It was revealed that cup-shaped and concentric ring forms of mitochondria resulted from invagination and that aberrant cristae such as the sheaflike and vesicular types were both derived from laminated cristae with vesicular structure.

Adenolymphoma↗
PubMedDate not supplied

A rapid three-dimensional measurement system for facial morphology by laser multi-slits.

A laser light-sectioning technique for measuring the three-dimensional shape of the face has been developed. Multi-slit lasers were used to minimize the recording time, and the accumulating technique of multiple images was used to reduce the memory size. The system can scan the entire human face within 6 seconds and develop a three-dimensional image in approximately 4 minutes. The accuracy of this system was found to be within a 0.4% relative error. The method has the advantages of being contact-free, rapid, automatic, and useful for three dimensional clinical assessment.

Cephalometry↗