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Biomedical subjects

Y Inaba

Publications and source records attributed to Y Inaba.

At least 361 records · Page 20Linked to original sources
PubMed1978

[Significance of computed tomography in therapeutic diagnosis of brain tumors (author's transl)].

Because of its noninvasive property of direct imaging of the size and shape of the lesion, CT scan is significant not only for the diagnosis of the brain tumors, but also for the assessment of its chronological and/or therapeutic change in size. Contrary to the conventional cerebral angiography and contrast encephalography, CT scan is feasible to detect the tumor repeatedly at short intervals. From March 1976 to October 1977, 197 cases of brain tumors were examined by CT, 6 tumors (1 pineal tumor, 2 cerebellar vermian tumors and 3 supratentorial tumors) of which were radiated after the initial CT scan and re-examined by CT at every 400-1,000 rads radiation, and their grade of radiosensitivity could be evaluated. Immediately after the radiation of 400 rads for five days to the large pineal tumor of a 16-year-old boy, CT exactly showed the markedly diminished size of the tumor, and the tumor disappeared on CT after the 4,000 rads radiation. Cerebellar vermian tumors suspected of medulloblastoma were also diminished in size on CT after the 600 rads radiation. One supratentorial tumor was radiosensitive and disappeared at the end of radiation therapy. Other supratentorial tumors were not changed on CT during the radiation. Procedures for the therapeutic diagnosis, when combined with CT, can easily indicate whether the tumor is radiosensitive or not, without any invasive examination and/or operation.

Adolescent↗
PubMed1978

Computed tomography of the head: clinical experience of the first 3000 scans with EMI scanner.

Computer tomography (CT) findings obtained from the first 3,000 scans on 2,031 patients were analyzed and discussions were made on various kinds of neurological diseases, especially from the neurosurgical point of view. CT showed an excellent resolution for three-dimensional morphological pattern of intracranial lesion with a high percentage of diagnostic accuracy as reported from other institutes, resulting in making much earlier morphological diagnosis of intracranial lesion possible than any other examination. Scan methods consisted of plain CT, contrast enhanced CT, and metrizamide CT cisternography. Sequential delayed enhanced CT offered more useful information for high diagnostic accuracy, particularly for nature of brain tumor. Metrizamide CT cisternography was performed for the evaluation of cerebrospinal fluid dynamics and diagnosis of skull base tumors. CT is a new, epoch-making and non-invasive diagnostic approach in neuroradiology and contributes to obtain the better achievement of neurosurgical results.

Adolescent↗
PubMed1978

[Radioisotope cisternographic study on intracranial arachnoid cyst (author's transl)].

The dynamics of the CSF circulation in six cases of intracranial arachnoid cysts was examined by RI cisternography suing 0.5 to 1.0 mCi of 169Yb DTPA or 50 to 100 microCi of 131I HSA injected into the lumbar subarachnoid space. Serial scintigrams were obtained with rectilineal scintillation scanner at 2, 4, 6, 24 and 48 hours after injection. The communication of the cavity of arachnoid cyst and subarachnoid space was recognized in all cases. The cysts were best visualized at 24 hours in most cases. Four patterns of the entry and stasis of RI in cysts were observed as follows, 1) rapid filling of RI into the cyst and delayed clearance, 2) both rapid filling and clearance, 3) slow filling and delayed clearance, 4) no filling.

Adolescent↗
PubMed1978

Development of inactivated vaccine for Akabane disease.

Virus inactivated by formalin or beta-propiolactone was superior to that inactivated by ether and heating in immunogenicity to mice. There were no significant differences in the antibody response of mice among such adjuvants as aluminum phosphate gel, aluminum hydroxide gel, and sodium arginate gel. When cattle were immunized with vaccine inactivated by formalin and adsorbed to aluminum phosphate gel, an excellent effect was obtained by injection with two doses of 3 ml each given at a 4-week interval. It was also suggested that mice and guinea pigs might be available for the potency test of vaccine. When calves and pregnant goats were injected with vaccine in the same manner as mentioned above, they were prevented from viremia and fetal infection caused by challenge virus. Even when stored at 4 degrees C for 12 months, vaccine was found to retain its stabilized immunogenicity. When pregnant cows were injected with vaccine in the field, the positive rate of neutralizing antibody was 88.5% in the 2 months after the first injection. When other pregnant cows were injected twice with vaccine, this rate was 34.6, 100, 65.4, and 45.8% in the 1, 2, 6, and 10 months, respectively, after the first injection. In another experiment, the antibody levels attained declined rather rapidly in several months. A single dose of vaccine given one year later provoked a rapid antibody response. The vaccination caused no clinical symptoms, abnormal birth, or decrease in milk yield in these cows.

Animals↗
PubMed1977

Congenital abnormalities in newborn calves after inoculation of pregnant cows with Akabane virus.

A fresh isolate of Akabane virus was inoculated intravenously into 11 seronegative pregnant cows at 62 to 96 days of gestation. Two of the cows were slaughtered 18 days post-inoculation, and the fetuses were examined; the remaining cows were allowed to give birth. All the inoculated cows developed viremia and neutralizing antibody for the virus, indicating that the cows were actually infected with the virus, although fever or any other clinical abnormalities were not noted. The virus further infected the fetuses. This was proved by virus isolation in one of the two fetuses from the slaughtered cows, and polymyositis was noted in both fetuses. Six of seven calves born alive had anti-Akabane antibody in their precolostral sera, indicating that in utero infection with the virus took place in these calves. Some of the in utero-infected calves demonstrated congenital abnormalities such as cerebral defect, hydranencephaly, and arthrogryposis. These findings provide additional evidence that Akabane virus is the etiological agent of epizootic abortion and congenital arthrogryposis-hydranencephaly syndrome in cattle.

Abortion, Veterinary↗
PubMed1977

[Indirect measurement of intracranial pressure, with special reference to its principles and experiments with animals].

A new technique for measurement of intracranial pressure was presented. By using this method a) absolute value of pressure, b) easy, simple and inexpensive long-term measurement and c) decrease in danger of infection are obtained. The apparatus consists of an external device which converts displacement of its membrane into quantitative change of beam and an internal chamber with two membranes that is implanted in a burr hole between scalp and dura mater. These devices have the same diameter and no direct connection each other. When a pressure in the external device is varied, a pressure-displacement curve of its membrane is resulted. The pressure of the external device at the point of inflexion of the curve is representative of the pressure in the internal chamber. In the animal experiment, satisfactory results were obtained.

Animals↗