Biomedical subjects

Y Inaki

Publications and source records attributed to Y Inaki.

21 records · Page 2Linked to original sources

PubMed1982

Intramolecular interaction of thymine and adenine bases in synthetic oligo- and polynucleotide models.

Four types of oligomer systems, ranging from monomers to hexamers, of linear polyethyleneimine derivatives having pendant thymine or adenine bases were prepared. In order to evaluate the intramolecular interaction between the pendant nucleic acid bases, ultraviolet spectra at various pH regions and proton NMR spectra at various temperatures were measured. The results on UV hypochromicities and pKa values led to the clarification of such interaction between the bases: adenine bases can be prone to interact intramolecularly by stacking, while the interaction between thymine bases is not due to stacking, but due only to residual interaction which takes place between neighboring chromophores.

Adenine↗

PubMed1980

Synthesis and interactions of poly-L-lysines containing nucleic acid bases.

Poly-L-lysine derivatives containing nucleic acid bases were synthesized. Conformation of the obtained polymers was studied by CD and ORD. Formation of the polymer complex was studied and was related to the conformation of the polymers.

Adenine↗

PubMed1979

Photochemical reactions on the synthetic polymers containing thymine bases.

Photodimerizations of N-2-isobutyloxyethyl thymine (T-M), bis[2-(5-methyl-1-pyrimidinyl)ethyl]glutarate (T-T), poly-N-2-methacryloyloxethyl thymine (P-MAOT) and poly-N-2-acryloyloxyethyl thymine (P-AOT) were studied in dimethylformamide solution. Quantum efficiencies of intramolecular photodimerizations were determined to be 0.0012 for T-T, 0.0084 for P-MAOT and 0.010 for P-AOT. In the case of T-M, however, intermolecular photodimerization did not occur under the reaction condition used. Quenching studies by using isoprene suggest that the photodimerization of T-T occurs predominantly through an excited triplet state, while that of P-MAOT and P-AOT occur through both singlet and triplet states. For the effect of adding model compounds containing adenine bases on this reaction, adenine derivatives acts as an inhibitor against this reaction by quenching the excited singlet state of thymine. The photodimers of T-T, P-MAOT and P-AOT were concluded to be two syn-fused cyclobutane- type dimers (cis-syn and trans-syn).

Photochemistry↗