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Biomedical subjects

Y Ishimoto

Publications and source records attributed to Y Ishimoto.

10 recordsLinked to original sources
PubMed1991

A study on the brain structures related to conditioned emotional response by means of [14C]2-deoxy-D-glucose method.

Brain structures activated during conditioned emotional response were studied by means of the [14C]2-deoxyglucose method. The experimental (CSE) animals were conditioned with paired 25 25-sec-long flicker sequences (CS) and 1-sec-long 150 V AC electric shocks (US), while the control (CSC) animals were given only 25 CS sequences. Average densities of a unit square (200 microns x 200 microns) of 47 nuclei or cortical areas in the left hemisphere were obtained from an autoradiogram and the optical density ratio (ODR), which is the relative optical density of each structure to that of the corpus callosum, was calculated. Comparison of ODRs of each structure from both groups revealed a significant increased uptake of [14C]2-deoxyglucose (P less than 0.05, Mann-Whitney U-test) in the caudal portion of area 10, area 2, area 18 and the hippocampal formation.

Animals↗
PubMed1990

Electroencephalographic changes during and after water intoxication.

A case of water intoxication with remarkable hyponatremia was investigated with a special reference to EEG changes during and after the episode. The patient recovered his EEG as his consciousness disturbance had improved through an intravenous infusion of high osmolality saline, correlating with the serum sodium level. Further, the clinical importance of recording EEG for water intoxication was stressed.

Adult↗
PubMed1990

Evoked potentials of self-interrupted Jacksonian epilepsy.

We describe a female case of Jacksonian epilepsy who can interrupt the spreading of her march by grasping her fingers firmly with her right hand. Neurophysiologically, Somatosensory evoked potential (SEP) was remarkably decreased in amplitude with pressure stimulation similar to her method. Such a change in SEP was observed also in a healthy subject. Accordingly, it is suggested that the stimulation only to the proprioceptor of fascia suppresses the activity in the cortex.

Aged↗
PubMed1979

Transaminative pathway of cysteine metabolism in rat tissues.

Enzyme activities of the transaminative pathway of cysteine metabolism in various rat tissues were examined. Liver was found the most active tissue, followed by kidney and heart. Liver and kidney were more pronounced in mercaptopyruvate sulfurtransferase activity than in cysteine transaminase activity; heart was more active in the latter. Red blood cells, which have pronounced sulfurtransferase activity, exhibited no transaminase activity, indicating the pathway is negligible in this tissue.

Animals↗
PubMed1977

Desulfuration of l-cysteine through transamination and transsulfuration in rat liver.

Desulfuration of L-cysteine by rat liver via a pathway of transamination followed by transsulfuration was studied using cyanide as a sulfur acceptor. More than a 5-fold increase in formation of thiocyanate from L-cysteine and cyanide was observed in the presence of 2-oxoglutarate and pyruvate. L-Cysteine aminotransferase and 3-mercaptopyruvate sulfurtransferase activities in the same preparations were also determined. It was concluded that L-cysteine was desulfurated through transamination and transsulfuration of the resulting 3-mercaptopyruvate, and that the rate-limiting step appears to be the transamination reaction.

Animals↗
PubMed1977

Transaminase of L-cysteine in rat liver mitochondria.

Transamination of L-cysteine in rat liver was examined. Specific activity of the reaction in mitochondria was found higher than that in cytosol. The mitochondrial reaction was shown to be catalyzed by two different enzymes. The first was active with 2-oxoglutarate and inactivated by heating at 60 degrees C for 10 minutes; the activity was protected from heat inactivation by the presence of 2-oxoglutarate. The second enzyme was active with pyruvate and more stable than the first under heat treatment; 2-oxoglutarate had little protective effect on this second enzyme. The two enzyme activities were separated by heat treatment and ammonium sulfate fractionation.

Animals↗