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Biomedical subjects

Y Itakura

Publications and source records attributed to Y Itakura.

At least 91 records · Page 5Linked to original sources
PubMed1988

Accuracy of digital palpation for size assessment of the prostate evaluated by transrectal sonography.

In order to clarify how precisely digital palpation gives information on prostatic size, evaluation of the size measurement of the prostate by means of transrectal sonography was performed on 1,543 subjects with various prostatic disorders. There was little agreement between the assessment of prostatic size by digital palpation and the ultrasonic measurement. The larger the prostate the less accurate was digital palpation. The prostatic size assessed by digital palpation was particularly dispersed widely in the prostate of 'hen's egg' size. It was proved that the size assessment by digital palpation was only effective statistically in a two-step differentiation, 'hen's egg' size and smaller. More complicated size classification was of little clinical value in digital palpation.

Evaluation Studies as Topic↗
PubMed1988

An improved method for the histological preparation of single hairs and dust samples--morphological and immunological examination.

An improved method of the serological and morphological investigation of human hair is reported. The hair was firmly fixed onto a microscopic slide with cellophane tape and observed microscopically to confirm the cuticula images and the presence of the medulla. A piece of the hair containing the medulla was dissected, embedded in paraffin, and a cross section of this hair was prepared. By treating the sample with immunohistochemistry (biotin-antibiotin ABC technique), the blood type of the hair was confirmed definitively. Dust containing shaved beard can be examined in the same way.

Adhesives↗
PubMed1988

[Percutaneous nephroureterolithotomy in two city hospitals: review of 102 cases].

The authors experienced 102 cases of percutaneous nephroureterolithotomy (PNL) in the urological clinic at two city hospitals between May, 1984, and July, 1986. Percutaneous access for renal pelvis was performed under interventional ultrasound and the disintegration of stones was mainly performed by an electric drill system. Stones were successfully removed in all the cases, although residual stones were recognized in 16 cases (15.7%). Complications were rather minor and were treated conservatively without open surgery. PNL is a very effective and promising method not only for university hospitals but also for the urological clinic in city hospitals.

Adolescent↗
PubMed1987

Tannins occurring in the toxic Brazilian plant Thiloa glaucocarpa.

Four tannins were isolated from dried leaves of Thiloa glaucocarpa, which is one of the plants causing poisoning of cattle in Brazil. These four tannins were determined from spectrometric and chemical evidence to be the ellagic C-glucosyl tannins vescalagin, castalagin, stachyurin and casuarinin. The main components, vescalagin and castalagin, are also known as constituents of oak (Quercus spp.), the toxicity of which for cattle is supposed to be due to tannins. Suggestions concerning the resemblance of the symptoms of poisoning by Thiloa glaucocarpa and by oak are supported by the presence of the constituents in both plants.

Acetylation↗
PubMed1987

Clinical, biochemical and enzymatic studies in type I hyperprolinemia associated with chromosomal abnormality.

A severe mentally retarded infant with type I hyperprolinemia associated with chromosomal abnormality is reported. The patient had a characteristic facial appearance of hyperprolinemia and suffered from convulsions after the age of 10 months. The child developed severe mental and motor retardation. The karyotype of the patient revealed partial duplication of the short arm in chromosome 10 using G banding techniques. The patient and her mother showed a fasting hyperprolinemia and an abnormal clearance curve after the proline load in the serum. The proline oxidase activities of the liver tissues obtained by biopsy in the patient was about 9% of those of controls. Kinetic studies and mixed experiments of the enzyme were with normal limits. Restriction of dietary proline at the age of 12 months revealed a prompt fall of the plasma levels of proline to the normal range, and a low proline diet was continued until the present time. During the period of dietary treatment, growth was satisfactory, but her mental development did not improve. From the developmental patterns of proline oxidase activities postnataldy, we speculated that restriction of dietary proline intake should be relieved with age.

Amino Acid Metabolism, Inborn Errors↗
PubMed1987

Immunoenzymatic studies of ornithine transcarbamylase (OTC) in liver of patients with OTC deficiency by enzyme linked immunosorbent assay (ELISA).

Antigen contents of ornithine transcarbamylase (OTC) protein in the liver of 5 patients with OTC deficiency and mutant mice were studied by ELISA. OTC activities in the liver tissues of 2 patients were 13.1% and 5.2% of the controls, respectively. The 2 patients' antigen contents of OTC protein were decreased in parallel with the enzyme activities. OTC antigen contents were not detected in the liver tissues of remaining 3 patients who had the complete type of OTC deficiency. Enzyme activities, kinetic properties and antigen contents of the OTC deficient mutant mice were the same as the results reported previously (Briand et al. 1982). The ELISA method for the assay of OTC antigen contents used in this study is more sensitive as compared with the radial immunodiffusion technique.

Animals↗
PubMed1987

[Analgesic effect of calcitonin in patients with metastatic bone lesions from urogenital cancer].

The analgesic effect of eel-calcitonin (Elcitonin) was evaluated in 10 patients with metastatic bone lesions from urogenital cancer. Five patients had renal cell carcinoma, while the remaining 5 patients had prostatic cancer. Eel-calcitonin was injected intravenously to each patient at a dose of 80 units every day. The drug was markedly effective for 3 patients, effective for 4 patients and ineffective for 3 patients. The effect was better for prostatic cancer than renal cell carcinoma.

Aged↗
PubMed1986

Absence of argininosuccinate lyase protein in the liver of two patients with argininosuccinic aciduria.

The enzyme defects in two cases of argininosuccinic aciduria were examined at the molecular level by enzymatic and immunological methods. No argininosuccinate lyase activity was detected in the liver or erythrocytes of either patient nor in the kidney or brain of one of the patients even in the presence of high concentrations of the substrate. The titration curve of antiserum to human argininosuccinate lyase with the liver extract from a control subject was not affected by the addition of the liver extracts from one of the patients. Double immunodiffusion analysis revealed a single precipitin line between the purified antiserum and the liver extract from a control, but no precipitin lines between the antisera and the liver extracts from the two patients. These results indicate a complete or almost complete defect of an immunologically cross-reactive material in the liver of the patients.

Amino Acid Metabolism, Inborn Errors↗
PubMed1986

Citrullinemia: quantitative deficiency of argininosuccinate synthetase in the liver.

Two cases of citrullinemia were reported. Case 1 was an one month old female. Her clinical course and findings were different from the fulminant type of neonatal citrullinemia reported in predominantly Caucasian countries. Our patient was well controlled under a low protein diet and essential amino acids till 9 months of age, but unfortunately she died of Reye's like syndrome. Case 2 was 31 year old male (at the time of death). He was admitted to our hospital because of hyperammonemia and mental retardation. By subsequent laboratory investigations he was diagnosed as having adult type of citrullinemia and died of hepatoma. Enzymological analysis revealed that argininosuccinate synthetase (ASS) activities in the liver tissues of the patients decreased to 40% (Case 1), 20% (Case 2) compared with those in control liver tissues. The other urea cycle enzyme activities were all within normal range. ASS activities in the kidney and brains of the two cases were within normal range. The kinetic constant values of ASS for three substrates in the tissues of liver and kidney were all normal. Results of immunochemical analyses indicated that citrullinemia in our patients was caused by a quantitative deficiency of ASS associated proteins of the liver and kidney tissues as to the molecular weight.

Adenosine Triphosphate↗