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Biomedical subjects

Y J Seo

Publications and source records attributed to Y J Seo.

12 recordsLinked to original sources
PubMed2001

Hematein inhibits tumor necrotic factor-alpha-induced vascular cell adhesion molecule-1 and NF-kappaB-dependent gene expression in human vascular endothelial cells.

Monocyte adhesion to the endothelium via adhesion molecules is one of the earliest events in atherogenesis. It has been suggested that vascular cell adhesion molecule-1 (VCAM-1) plays a very important role in the recruitment of monocytes in atherosclerosis. The aim of our study was to evaluate whether hematein can influence the expression of VCAM-1 and the transcription of nuclear factor-kappaB (NF-kappaB)-dependent genes. Immunohistochemistry revealed that mouse aortic artery endothelial cells express VCAM-1 after feeding a high cholesterol diet for 8 weeks. Hematein dose dependently suppressed TNF-alpha-induced VCAM-1 in both surface (30.8%) and soluble protein (65%) production in HUVECs. The transcription level of VCAM-1 was measured by Northern blot analysis, and decreased VCAM-1 protein expression was associated with a reduction of VCAM-1 mRNA expression. Transient transfection study of NF-kappaB promoter construct and electrophoretic mobility shift assay suggested that hematein inhibited both NF-kappaB-dependent gene expression and NF-kappaB activation induced by TNF-alpha. Our results suggest that the down-regulation of VCAM-1 expression by hematein may in part be due to the inhibition of NF-kappaB-dependent gene expression.

Animals↗
PubMed2001

Age and gender difference in habitual sleep-wake rhythm.

We analysed the effects of age and gender on the habitual sleep-wake rhythm in 2252 randomly selected subjects living in Shimonoseki, Japan. Subjects were divided into 21 age groups with a matching number of males and females for each. During the period from primary school to adolescence, the bedtime became delayed and sleep length decreased with age. After that period, with increasing age, bedtime became earlier and sleep length increased. The number of awakenings and the length of daytime naps increased markedly with epoch after 50 years and 70 years of age, respectively. Gender differences were considered to be due to the women's social and domestic customs in Japan.

Adolescent↗
PubMed2000

Sleep-wake behavior of shift workers using wrist actigraph.

The sleep-wake behavior and the effects of aging on the tolerance of night shift were investigated using wrist actigraph for 12 Korean male workers of a continuous full-day three-team three-shift system. The wrist actigraph data were obtained for about 21 days (1 shift cycle) for each subject. During night duty, total sleep time decreased, the number of naps and nap length during on-duty or off-duty periods increased, and the level of activity decreased with increasing age. These results suggest that the tolerance to night shift becomes weaker with increasing age.

Adult↗
PubMed2000

Malignant hidroacanthoma simplex: a case report.

Hidroacanthoma simplex is a benign tumor of the skin originating from or showing differentiation to the sweat glands. It grossly resembles seborrheic keratosis of Bowen's disease and histologically shows intraepidermal focal growth of epithelial cells. Malignant transformation of this tumor is rare. We report a case of pigmented hidroacanthoma with malignant transformation in a 67-year-old woman. There was a 20-year history of a skin lesion on the right thigh, which first appeared as a small verrucous papule, progressed to a dark-brown colored patch, and then to a pigmented plaque. Histologically, the primary tumor was composed of small squamoid cells with marked cellular atypia. Most of the tumor cells were located in the epidermis. Immunohistochemically, the cytoplasm of some tumor cells showed a positive reaction for epithelial membrane antigen, but not for either carcino-embryonic antigen or the S-100 protein.

Acrospiroma↗
PubMed1999

Sleep and chronotype for children in Japan.

To investigate the change in sleep-wake habits, Morningness-Eveningness preference, and sleep status by grade, 512 students aged from 6 to 18 years, were tested using the Morningness-Eveningness Questionnaire and Sleep Questionnaire. The habitual waking time showed no difference by grade, but the students above Grade 7 reported a significantly later habitual bedtime and had a shorter length of sleep on weekdays than the students below Grade 6. The students above Grade 7 reported a significant difference between habitual and preferred waking times but did not show a difference between habitual and preferred bedtimes. Although the sleep length during weekends became shorter from Grade 1, the sleep length of students above Grade 8 showed a significant difference between the weekdays and weekends; they had more than nine hours of sleep on the weekends. The percentage of students taking a nap during a school lesson significantly increased across Grades 8 to 12. The mean score on the questionnaire decreased across grades and the decrease was significant at Grade 7. Both the habitual and preferred bedtimes and waking times were later from the Morning, Intermediate, to the Evening types across grades. The difference by chronotype in preferred waking time increased for groups from the primary, junior high, to the high school. Also, the sleep lengths both weekdays and weekends decreased from the Morning, Intermediate, to the Evening type for all grades. We suggested that the delay of sleep phase, reduction of sleep length, increased daytime napping, and transition to Evening type were remarkably represented around Grade 7.

Adolescent↗
PubMed1998

Evaluation of human activities and sleep-wake identification using wrist actigraphy.

The purpose of this study is to investigate the count-characteristics of wrist actigraphy in basic human activities and to discuss the agreement of sleep-wake identification between polysomnography (PSG) and wrist actigraphy during nocturnal sleep. There was a distinct distribution of actigraphy counts over the studied activities. The evaluation of sleep-wake scoring using the wrist actigraphy agreed 96.9% with the polysomnographic scoring during nocturnal sleep.

Activity Cycles↗
PubMed1998

Effects of aging on morningness-eveningness and sleep habits in Korean and Japanese workers.

The Morningness-Eveningness Questionnaire and Life Habits Inventory were given to Korean and Japanese workers. The distributions of scores on the questionnaire for these two groups were normal and its mean slightly moved to the Morning type with aging. It is noteworthy, however, that the mean scores of Korean workers was lower than those of the Japanese workers. The self-reported waking times and bedtimes for the two groups gradually became earlier with aging. From these results it could be said that aging was an factor that led to the difference of circadian phase.

Adult↗
PubMed1998

Sleep in relation to age, sex, and chronotype in Japanese workers.

The Morningness-Eveningness Questionnaire and Life Habits Inventory were administered to 622 Japanese workers matched for sex and age. We investigated the distributions of the scores on the Morningness-Eveningness Questionnaire and sleep-wake habits by age and sex. Subjects were classified into five age groups and three chronotypes. The distributions and mean scores on the questionnaire advanced slightly toward the Morning type from the young to the aged group. The habitual bedtimes and waking times were significantly earlier in all the chronotypes from the young to the aged group, and the preferred bedtimes and waking times were also clearly earlier from the young to the aged group. The length of sleep was shorter for the Evening than the Morning types, especially in the group below 24 yr. The differences in habitual and preferred sleep length were greater than 1 hour for all age groups, especially the two groups under 34 yr. The number of awakenings during night sleep increased from the young to the aged group for all chronotypes. The older Evening type tended more toward frequent napping and longer naptime. The variabilities of bedtime and sleep length were larger for the young and Evening type than for the old group and Morning types. Further, the mood upon waking and satisfaction with sleep length were better in the aged Evening type than the young Morning type. The women under 44 yr. woke up earlier than the men of the same age, and the women of the 35-54 yr. groups had a shorter length of sleep than others. These may be related to childcare and housework. These results indicated that the phase of circadian rhythms had moved forward from the young to the aged group, and the individual's rhythm, of those that were aged Morning types, showed better agreement with sleep-wake rhythms than did others.

Adult↗
PubMed1997

Scores on morningness-eveningness and sleep habits of Korean students, Japanese students, and Japanese workers.

The Morningness-Eveningness Questionnaire and Life Habits Inventory were given to three groups of the same mean age: 533 Korean students, 468 Japanese students, and 311 Japanese workers. The distributions of scores on the questionnaire for these three groups are normal; however the Japanese students' distribution was slightly skewed towards the Evening type. The self-reported waking times and bedtimes for the three groups were late in the order of Morning, Intermediate, and Evening types. It is noteworthy, however, that the Korean students woke earlier than the Japanese students, and the workers always went to bed and woke earlier than the students. For the groups the variations in bedtime, waking time, and length of sleep were large, the sleep latency was long, and mood of the participants upon waking was bad in the order of the Morning. Intermediate, and Evening types. The scores of the Korean students were distributed more highly in the Morning type than were the Japanese students', but the students' sleep habits in both countries were quite similar. The subjects categorized as Evening types had more irregular sleep habits than those of the Morning type. In comparison with the student groups, Japanese workers of the same mean age had higher scores and slightly different sleep habits. The change in sleep habits could be seen as a result of the demands of employment, and the probable basis for difference in scores.

Adolescent↗
PubMed1997

Effects on sleep patterns during simulated oxygen-helium saturation diving at 180 and 230 m.

The standard polysomnography of four divers was recorded respectively through 188 nights in two simulated experiments under a hyperbaric saturation environment of He-O2 mixture at the depths of 180 and 230 m. In the two diving conditions on the bottom nights and decompression nights, the following was shown: A reduction of total sleep time, a decrease of sleep efficiency; an increase of sleep latency, frequency of wake after sleep, number of sleep stage shifts, and a lengthening of stage 1 sleep; and a reduction of stage 4 sleep. In the 230 m-diving condition on the bottom nights and the decompression nights, only stage 4 sleep showed a significant decrease when compared with the 180 m-diving condition. It is assumed that both were conditions in which awakening was likely to happen and there would be no disorders of fundamental sleep patterns.

Adult↗
PubMed1990

The effect of lectin from Taro tuber (Colocasia antiquorum) given by force-feeding on the growth of mice.

In earlier experiments in our laboratory, a lectin from the Kintoki bean (Phaseolus vulgaris) was found to have not only erythrocyte agglutinating activity but also toxicities for mice and rats, including growth inhibitory activity and even lethal activity. A number of studies on legume lectins have been carried out in other laboratories as well. But relatively little attention has been paid to lectins from non-leguminous foods. In the present study, we chose Taro tuber as a source of non-leguminous lectins and prepared two types of Taro tuber lectin. One was crude lectin precipitated with ammonium sulfate from the aqueous extract and the other was pure lectin isolated as we described previously. The two were compared with regards to the antinutritional functions in mice. The daily doses were 100 mg for either intact or autoclaved crude lectin, which was a maximum amount available to give to mice in 1 ml, and 30 mg for the pure lectin which was equivalent to 100 mg of the crude lectin in hemagglutinating activity. Control mice were given 1 ml of water and the experiment was conducted for 6 days. Growth retardation was found in the mice given either lectin, but no significant difference was found in the weight increase between the control group and the autoclaved lectin group. For 3 days during the experimental period, physical activity was measured as an index of vigor of mice. The activities of the crude lectin and the pure lectin groups leveled down to 62.9 and 64.2% of that of the control group, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Alkaline Phosphatase↗