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Biomedical subjects

Y Jacquet

Publications and source records attributed to Y Jacquet.

6 recordsLinked to original sources
PubMed1998

[Perinatal HIV transmission prophylaxis in the Liege region].

In Liège, since February 1994, Protocole ACTG 076 has been followed for prevention of perinatal transmission of VIH. The pregnant women are treated by AZT during pregnancy and delivery. The newborn is also treated during 6 weeks. Following this treatment strategy, vertical transmission rate of VIH has dropped from 25.6% to 8.7%. The PCR is particulary promising for the early detection of infection in newborn, but definitive conclusion about infective status of the newborn can't be done during the first week of life. The potential role of intrapartum transmission is now under evaluation in the hope to establish the safest mode of delivery.

Anti-HIV Agents↗
PubMed1991

[Multi-disciplinary approach to adolescents with problems. The Cholet experience].

The authors report their experience of management of 12-18 years adolescents in the year 1987 using a multidisciplinary approach. Eighty adolescents were hospitalized in the adolescent ward (5 beds) of a pediatric unit (38 beds; 1,691 admissions). Follow-up was carried out in a specialized out-patient clinic (SOPC) (660 patients) in a common-place apartment lent by the town-hall. A day hospital (12 beds) was reserved for those patients presenting with more important psychological problems. The causes for hospitalization (64% of females, 36% of males) consisted for 1/3 of somatic problems and for 2/3 of psychological problems, of which 40% were suicide attempts. 70% of these adolescents were met again in the SOPC (36% by a pediatrician, 29% by the pedopsychiatric team). Such a structure, open towards the outside, working in a multifocal and multidisciplinary way but with the same care team allows, in spite of some difficulties and doubts, responding to the local needs and facing a more global management and a better follow-up of adolescents with difficulties.

Adolescent↗
PubMed1988

A dystonia-like syndrome after neuropeptide (MSH/ACTH) stimulation of the rat locus ceruleus.

The movement disorder investigated in these studies has some features in common with human idiopathic dystonia, and information obtained in these studies may be of potential clinical benefit. The present experimental results indicated that peptidergic stimulation of the LC resulted in a NE-mediated inhibition of cerebellar Purkinje cells located at terminals of the ceruleo-cerebellar pathway. However, it is not certain as to the following: (a) what receptors were stimulated by the ACTH N-terminal fragments at the LC that resulted in this disorder; (b) whether NE, released onto Purkinje cell synapses located at terminals of the ceruleo-cerebellar pathway, did indeed cause the long-term depression at Purkinje cell synapses (previously described by others) that resulted in the long duration of the movement disorder; (c) whether the inhibition of inhibitory Purkinje cells resulted in disinhibition or increased excitability of the unilateral cerebellar fastigial or interpositus nuclei, the output targets of the Purkinje cell axons, that may have been an important contributing factor to this disorder. These questions are currently being investigated.

Adrenocorticotropic Hormone↗
PubMed1978

Test for oral and postingestional factors mediating differential acceptability of morphine, methamphetamine, and chlordiazepoxide drinking solutions.

The relative degrees to which aversive oral (presumably gustatory) and postingestional variables attenuate the voluntary drinking of morphine, methamphetamine, and chlordiazepoxide solutions by rats were assessed by comparing immediate acceptability with subsequent acceptability. Results indicated that morphine solutions (0.01--0.05%) are avoided primarily because of unpalatability, while methamphetamine (0.005--0.02%) and chlordiazepoxide solutions (0.02--0.08%) are avoided primarily because of aversive postingestional effects.

Administration, Oral↗
PubMed1977

Perfusion-fixation procedure for immediate histologic processing of brain tissue.

The rat brain can be hardened instantly by in vivo perfusion of the head with 50 ml of 50% Formalin followed by 50 ml of 10% sucrose-formalin. The brain can be sectioned on the freezing microtome immediately after the above perfusion. With routine staining procedures for unmounted sections histological slides of excellent quality can be prepared within an hour after perfusion.

Animals↗