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Biomedical subjects

Y Kakudo

Publications and source records attributed to Y Kakudo.

At least 19 recordsLinked to original sources
PubMed1989

Permeability increase in rat submandibular gland by glandular substance P.

When the chorda tympani was stimulated at 20 Hz, infused horseradish peroxidase (HRP) entered the saliva through the tight junctions in the rat submandibular gland. This response was not inhibited by atropine but was reduced by a substance P(SP)-antagonist. The increase in junctional permeability for HRP never occurred in the gland that was stimulated at 5 Hz or in the SP-depleted gland. Our data suggest that the effect of parasympathetic stimulation on the increase in junctional permeability for macromolecules was due to the release of SP in the gland.

Animals↗
PubMed1986

Effect of streptozotocin diabetes on gingivitis in plaque-susceptible rats.

The periodontal pocket probing depths of mandibular incisors of plaque-susceptible (Sus) rats, which spontaneously exhibit gingivitis with accumulation of plaque, were increased 20 days after injection of streptozotocin (70 mg/kg, i.v.). The accumulated plaque weights were also increased in Sus rats with streptozotocin diabetes, and a positive correlation was found between the plaque weights and the pocket depths. Histological findings showed that this inflammatory reaction in gingival tissue was higher and more extensive in diabetic Sus rats than in control Sus rats. These findings suggest that the accumulated plaque is the important factor for the severe breakdown of gingival tissue in this experimental model.

Animals↗
PubMed1985

Sialographic damage in rat submandibular gland.

The damage caused to rat submandibular glands by intraductal injection was examined. When a small volume of isotonic saline was injected, even if salivation was not influenced, salivary composition was greatly affected because the intercellular junctions of the duct cells were damaged. Intraductal injections of hyperosmotic solutions or highly viscous liquids were more effective in damaging intercellular junctions. When interpreting the significance of a salivary composition in clinical diagnosis, it is necessary to consider the sialographic damage which might influence the salivary composition.

Animals↗
PubMed1983

Secretion and re-absorption of glucose in rat submandibular and sublingual saliva.

Glucose permeation from blood to saliva appeared to follow the paracellular pathway in rat submandibular and sublingual glands, and the permeability was much higher in the sublingual than in the submandibular gland. The duct system re-absorbed glucose in the submandibular but not the sublingual gland. The glucose concentration in sublingual saliva was inversely related to the flow rate.

Animals↗