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Biomedical subjects

Y Kurimoto

Publications and source records attributed to Y Kurimoto.

61 records · Page 4Linked to original sources
PubMed1980

Immunopharmacological approach to Forssman shock.

Forssman shock (FS) following the intravenous injection of antisheep erythrocyte antibody into guinea pigs resulted in fatal systemic shock with marked decrease in CH50 values of complement, leucocyte, and platelet counts, and a prolongation of blood coagulation time. In addition, there was an increase in lactate dehydrogenase activity, and decreases in both esterase activity and fibrinogen levels were noted. F(ab')2 of antisheep erythrocyte IgG antibody was not capable of eliciting FS. Cobra venom factor showed a fairly potent inhibition of FS. Leukopenia induced by cytosine arabinoside given intraperitoneally for 5 days had no effect on FS. Colchicine, which decreased the leucocyte count, did not inhibit fatal systemic shock. Administration of heparin or trasyrol did not prevent FS. The present findings demonstrate that FS is inhibited by anticomplementary agents but not by drugs which affect leucocyte and platelet counts, the coagulation system or serum proteases.

Anaphylaxis↗
PubMed1979

Airflow obstruction in asthma induced by inhalation of small minimum doses of allergen.

In order to define allergen-induced bronchial responses, sixteen asthmatics, assessed as mild (twelve cases) and moderate (four cases) were tested by inhalation of small doses of house dust allergen. The minimum dose was first determined in each patient. It caused no abnormal respiratory sensation, while a fall of Vmax50 air with no change or slight decrease of Vmax50 He-O2 and a rise of density dependence ratio were observed. Inhalation tests with multiples of the minimum dose were made and showed that the minimum dose was dependent on the individual, his condition and induced airflow obstruction in a dose-related fashion.

Administration, Intranasal↗
PubMed1978

Specific IgE estimations by RAST in Japanese asthmatics compared with skin, passive transfer and bronchial provocation tests.

198 asthmatics and twenty healthy persons were studied by RAST and in vivo tests with four common inhalant allergens. (a) Higher RAST classes were elicited with mite (Dermatophagoides farinae) extract and lower classes with other allergens. The agreement between positive RAST and skin or P-K tests was highest with the mite extract. RAST sensitivity was dependent on the kinds of allergens and was most sensitive to mite extract. Positive RAST was most closely related to the prick test reactions. (b) RASTs to house dust and mite extract were examined in terms of the threshold dosage of house dust and also the types of bronchial response (early, dual and late) induced by a certain amount of house dust; higher RAST classes were found in subjects with bronchial response to the dual or early type, elicited by a threshold dosage of diluted extract, while lower RAST classes were found in cases of the late-type response elicited by the threshold dosage of concentrated extract. (c) Changes in IgE antibodies to house dust and mite extract were estimated in patients with positive house dust provocation. A greater increase occurred in cases of dual or early response, a smaller increase in those with a late response. Despite discordances in skin tests and RAST between house dust and mite extracts, the increases in IgE antibodies to mite extracts as well as house dust were observed in all cases, presumably caused by an allergenic identity between the allergens.

Adolescent↗
PubMed1975

Relationship among skin tests, bronchial challenge and serology in house dust and Candida albicans allergic asthma.

One hundred and ninety-six asthmatic patients were examined by inhalation challenge using house dust and candida albicans; an early, dual or late bronchial response was induced where IgE, C3 and C4 were elevated. In some of late responses by candida inhalation there was a decrease or almost no increase in IgE and a fall in C3 and C4. There was a considerable correlation between skin tests and bronchial responses. An induced bronchial response, early, dual or late, was identified as Type I, While candida-induced late bronchial responses were Type I and Type III. There is some question whether Type I plus Type III mechanism may be involved in the dual bronchial response provoked with candida.

Adolescent↗
PubMedDate not supplied

Comparative study of retinal nerve fiber layer loss in normal-tension glaucoma and chronic open-angle glaucoma.

PURPOSE: To clarify whether loss of the retinal nerve fiber layer in normal-tension glaucoma (NTG) differs from that in chronic open-angle glaucoma (COAG). METHODS: Using a scanning laser polarimeter, retinal nerve fiber layer thickness (RNFLT) was measured in 21 patients with NTG, 21 patients with COAG and 21 normal controls. The three groups were matched for age, and the NTG and COAG groups were matched for visual field loss. RESULTS: The mean RNFLT was significantly less in the NTG than in the control group and less in the COAG than in the controls and NTG group. Although the correlations between the parameters of RNFLT and homotopic visual field measurements were significant in COAG, none of the correlations were significant in NTG. CONCLUSIONS: The present results suggest that loss of the retinal nerve fiber layer in NTG differs from that in COAG.

Chronic Disease↗