Biomedical subjects

Y L Hsu

Publications and source records attributed to Y L Hsu.

21 records · Page 2Linked to original sources

PubMed1989

Comparison of RNAs and polypeptides of infectious pancreatic necrosis virus isolates from eel and rainbow trout.

Thirteen isolates of infectious pancreatic necrosis virus (IPNV) from eel and rainbow trout in Taiwan were compared with the selected serotypes AB, SP and VR-299 by PAGE analysis of their RNA genomes and early polypeptides. All the IPNV isolates from eels (1984 to 1986) from Lu Kang and Ping Tung, and from rainbow trout eggs and fry from Dan Sway (1985 to 1986) were most closely related to the AB serotype. However four rainbow trout isolates from Dan Sway (1984) had a similar RNA pattern to that of VR-299, whereas their early polypeptides were different, showing evidence of some mutations. Both RNA and polypeptide PAGE patterns were used to distinguish the isolates from known selected IPNV strains showing that this approach can be used for epizootiological studies.

Anguilla↗

PubMed1988

Ageing and infection.

An increased morbidity and mortality due to infectious disease has been noted in the ageing. Two alternative explanations may account for this. Changes in the immune system and inflammatory responses with age or an increase in age-related diseases may underlie the increased susceptibility. A review of studies of healthy older individuals demonstrates changes in the immune system with ageing but minimal change in the inflammatory response. Investigations of severe infection in older nursing-home patients requiring hospitalization indicate that infection as a cause of admission and death is significantly more common in individuals who are bedridden because of serious cardiovascular or neurological disease and require urinary catheterization. The evidence indicates that underlying disease, not the senescence of host resistance, leads to severe infection in the ageing.

Adult↗

PubMed1986

Occurrence of different types of infectious hematopoietic necrosis virus in fish.

The virion protein patterns of 71 isolates of infectious hematopoietic necrosis virus (IHNV) from the Pacific Northwest were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of [35S]-methionine-labeled virus. This analysis led to the classification of these virus isolates into four or more types. Type 1 virus was characterized by a nucleocapsid protein with an approximate molecular weight of 40,500. Type 2 and type 3 viruses have nucleocapsid proteins with molecular weights of 42,800 and 43,250, respectively. Type 2 virus was responsible for the recent epizootics of IHNV among fish in the lower Columbia River. The California IHNV isolates were type 3 with the exception of some of those isolated from fish at the Coleman Hatchery on the Sacramento River. These Coleman Hatchery isolates belonged to a type 4 virus group characterized by a larger glycoprotein of approximately 70,000 molecular weight. All other viruses examined had glycoproteins of 67,000 molecular weight. The "type 5" virus isolates were grouped together because they were not sufficiently distinct to warrant classification into a separate type. These findings have been useful in determining that a particular virus type is characteristic for a geographic area and will infect many different salmonid species in that area and the same type isolated from parental fish is responsible for the subsequent outbreak of the diseases in progeny.

Animals↗