Biomedical subjects

Y L Loh

Publications and source records attributed to Y L Loh.

3 recordsLinked to original sources

PubMed2001

Fast Chebyshev-polynomial method for simulating the time evolution of linear dynamical systems.

We present a fast method for simulating the time evolution of any linear dynamical system possessing eigenmodes. This method does not require an explicit calculation of the eigenvectors and eigenfrequencies, and is based on a Chebyshev polynomial expansion of the formal operator matrix solution in the eigenfrequency domain. It does not suffer from the limitations of ordinary time-integration methods, and can be made accurate to almost machine precision. Among its possible applications are harmonic classical mechanical systems, quantum diffusion, and stochastic transport theory. An example of its use is given for the problem of vibrational wave-packet propagation in a disordered lattice.

Journal Article↗

PubMed2001

Origin of the boson peak in systems with lattice disorder.

The origin of the boson peak in models with force-constant disorder has been established by calculations using the coherent potential approximation. The analytical results obtained are supported by precise numerical solutions. The boson peak in the disordered system is associated with the lowest van Hove singularity in the spectrum of the reference crystalline system, pushed down in frequency by disorder-induced level-repelling and hybridization effects.

Journal Article↗

PubMed2001

Control of exuT activity for galacturonate transport by the negative regulator ExuR in Erwinia chrysanthemi EC16.

The negative regulatory protein ExuR in Erwinia chrysanthemi regulates expression of the galacturonate uptake (exuT) and utilization (uxaA, uxaB, uxaC) genes. We cloned and determined the nucleotide sequence of the exuR gene from E. chrysanthemi EC16. Analysis of the deduced amino acid sequence indicates that this protein possesses a helix-turn-helix motif and belongs to the GntR family of transcriptional repressors. Northern blot analysis and studies with transcriptional fusions of exuT in wild-type and exuR mutant backgrounds indicate that exuT transcription is deregulated in the exuR strain in vivo and in planta. [14C]-galacturonic acid uptake was constitutively high under inducing and noninducing conditions in the exuR mutant. Maximal exuT transcription activity was observed within 8 h of bacterial inoculation into potato tubers, well before any visible symptoms of disease were detected. This suggests that ExuT transport activity in E. chrysanthemi is important in the early stages of disease development.

Amino Acid Sequence↗