Biomedical subjects
Y L Lynfield
Publications and source records attributed to Y L Lynfield.
Angiosarcoma of the scalp.
The clinical appearance, histopathology, and fulminating course of an angiosarcoma of the scalp in a 57-year-old man is described. It enlarged rapidly, developed satellite nodules, metastasized to the lungs, and was fatal within five months.
Cutaneous reaction to spironolactone resembling lupus erythematosus.
A cirrhotic male patient was admitted with a skin eruption. He had been taking spironolactone and hydrochlorothiazide for two months prior to admission. The morphology and distribution of skin lesions resembled that of systemic lupus erythematosus (SLE). Histologic changes in the skin biopsy specimen were consistent with SLE. Biopsy specimens of normal and affected skin were reported to show weak focal deposition of IgM and complement at the dermal-epidermal junction. However, there was a striking absence of serologic evidence of SLE. The rash disappeared when all medications were discontinued and reappeared when the patient was given spironolactone. The character and distribution of the rash after spironolactone administration was identical to the previous lesions. It disappeared again when spironolactone was withdrawn. This response to spironolactone is good evidence that it and not chlorothiazide was responsible for the rash. The latter drug has been reported to cause SLE-like skin changes.
Myocardial infarction in dermatomyositis.
A case of dermatomyositis manifesting electrocardiographic and vectorcardiographic changes compatible with an inferior and anterolateral wall myocardial infarction is presented herein. The nonocclusive nature of the heart muscle damage is evidenced by perfectly normal coronary artery angiography. We believe that this is the first reported case of a myocardial infarction pattern apparently due to dermatomyositis.
Nephrotic syndrome and granulomatous hepatitis in secondary syphilis.
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Lupus erythematosus exacerbated by griseofulvin.
Because griseofulvin is one of the safest systemic medications, its side effects are often forgotten. This paper serves as a reminder that griseofulvin can precipitate or exacerbate lupus erythematosus. Two patients are described: one had a photosensitivity reaction to griseofulvin which precipitated discoid LE skin lesions, without any previous evidence of LE. The other, who had known systemic LE, developed a systemic reaction, consisting of fever and malasise.
Poikiloderma vasculare atrophicans.
A 46-year-old Negro man with poikiloderma vasculare atrophicans is described. The disease progressed graduall.y for 22 years, with lesions appearing over the neck, trunk and extremities in an asymmetrical distribution, but it did not become lymphoma or collagen disease. Treatment did not appear to influence the course of the disease.
Familial benign chronic pemphigus: report of a case.
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Fournier's gangrene of the scrotum.
Gangrene involving the male genitalia is extremely rare. It may occur without any predisposing cause. This necrotic process passes through various stages, and is self-limited. No radical surgical procedure is indicated. A case of typical Fournier's gangrene of the scrotum is presented.
Letter: Transient acantholytic dermatosis.
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Pemphigus erythematosus provoked by allergic contact dermatitis. Occurrence many years after thymoma removal.
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Bacteria, skin sterilization, and wound healing in psoriasis.
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Benign familial chronic pemphigus.
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Allergic contact sensitization to gentamicin.
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