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Biomedical subjects

Y Laberge

Publications and source records attributed to Y Laberge.

4 recordsLinked to original sources
PubMed1993

"No stent, no diversion" Mathieu hypospadias repair.

The Mathieu procedure is a surgical technique for anterior hypospadias repair. The disadvantage of this technique is the prolonged hospital stay associated with postoperative urinary diversion. In an effort to reduce the length of hospital stay the authors carried out a prospective study to determine the usefulness of urethral stents and urinary diversion after Mathieu repair. Seventeen boys (mean age 4.1 years) formed the experimental group, and 19 boys (mean age 4.6 years) served as controls. Urinary diversion and urethral stents were used postoperatively in the control group but not in the experimental group. After a minimum of 6 months of observation the complications noted in both groups were found to be similar. The authors conclude that urinary diversion and urethral stents have no beneficial effects on surgical outcome but do prolong hospital stay.

Child, Preschool↗
PubMed1987

Correlations between the human sperm-hamster egg penetration assay and in vitro fertilization results.

The human sperm-hamster egg penetration assay (SPA) has been used to evaluate male fertility under in vivo conditions. The test is not only unstandardized, but agreement does not exist as to the lower limits of normal penetration rates. Therefore, it is not surprising that there is considerable doubt as to whether any correlation exists between SPA results and the behavior of sperm in an in vitro laboratory situation. We investigated this question by examining the SPA results and the subsequent fertilization and cleavage rates in the in vitro fertilization program at Pennsylvania Hospital. The sperm from men whose SPA results were 11% or more fertilized 86% of the morphologically normal and mature human oocytes to which they were exposed. Men whose SPA scores ranged from 1% through 10% fertilized 65% of human oocytes, and men whose sperm failed to penetrate hamster eggs still were able to fertilize 41% of the human oocytes. The differences between these groups are statistically significant. This information can be of practical prognostic value during in vitro fertilization cycles in which the number of mature oocytes seen ultrasonographically appears to be at a minimum.

Animals↗
PubMed1986

Early experience with the GIFT procedure.

Gamete intrafallopian transfer (GIFT) was performed in 19 cycles on 15 couples whose infertility had proven resistant to other treatments. Indications included infertility associated with immunologic factors, seminal deficiencies, endometriosis and infertility without a diagnosed etiology. Any history or finding of tubal disease served as an exclusion. Infertility was primary in ten couples and secondary in five, three of whom had conceived previously with a semen donor. Stimulation protocols included clomiphene citrate (CC) and human menopausal gonadotropins, CC alone and gonadotropins alone. Males were screened with the hamster egg sperm penetration assay. Four conceptions were recorded, and three are ongoing. Advantages of this procedure include acceptance by the major orthodox religions, avoidance of extracorporeal incubation and physiologic entry of the embryo into the uterine cavity. Disadvantages include the inability to determine if fertilization has occurred in the absence of pregnancy, the theoretical risk of increased ectopic gestation and tubal infection, and perhaps an increase in multiple gestations.

Adult↗